Human telomerase reverse transcriptase messenger RNA (TERT mRNA) as a tumour marker for early detection of hepatocellular carcinoma

Arab Journal of Gastroenterology

Volumn 15, Issue 2, 2014, Pages 68-71

  El Mazny, Ahmed ^a   Sayed, Mohamed ^a   Sharaf, Sahar ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Hepatocellular carcinoma; Serum human telomerase reverse transcriptase messenger RNA (hTERT mRNA); Foetoprotein

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA FETOPROTEIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BILIRUBIN GLUCURONIDE; MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR MARKER; TELOMERASE; TERT PROTEIN, HUMAN;

ADULT; AGE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALPHA FETOPROTEIN BLOOD LEVEL; ANAMNESIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EARLY DIAGNOSIS; ECHOGRAPHY; FEMALE; GENDER; HUMAN; HUMAN TISSUE; INTERNATIONAL NORMALIZED RATIO; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION TEST; MALE; PHYSICAL EXAMINATION; PREDICTIVE VALUE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TUMOR VOLUME; BLOOD; CARCINOMA, HEPATOCELLULAR; GENETICS; LIVER NEOPLASMS; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; EARLY DETECTION OF CANCER; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RNA, MESSENGER; TELOMERASE; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL;

EID: 84905238259     PISSN: 16871979     EISSN: 20902387     Source Type: Journal    
DOI: 10.1016/j.ajg.2014.04.001     Document Type: Article

References (14)

1. El-Serag H.B. Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 2002, 35(Suppl 2):S72-78.
2. Velazquez R.E., Rodriguez M., Navascues C.A., et al. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis. Hepatology 2003, 37:520-527.
3. Rahman El-Zayadi A., Abaza H., Shawky S., et al. Prevalence and epidemiological features of hepatocellular carcinoma in Egypt - a single center experience. Hepatol Res 2001, 19:170-179.
4. Dohmen K., Shirahama M., Onohara S., et al. Differences in survival based on the type of follow-up for the detection of hepatocellular carcinoma: an analysis of 547 patients. Hepatol Res 2000, 18:110-121.
5. El-Serag H.B., Marrero J.A., Rudolph L., et al. Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 2008, 134(6):1752-1763.
6. Kopreski M.S., Benko F.A., Kwak L.W., et al. Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin Cancer Res 2004, 5:1961-1965.
7. Chen X.Q., Bonnefoi H., Pelte M.F., et al. Telomerase RNA as a detection marker in the serum of breast cancer patients. Clin Cancer Res 2005, 6:3823-3826.
8. Wright W.E., Shay J.W. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 2000, 6:849-851.
9. Miura N., Shiota G., Nakagawa T., et al. Sensitive detection of hTERT mRNA in the serum of patients with hepatocellular carcinoma. Oncology 2003, 64:430-434.
10. Tani N., Ichikawa D., Ikoma D., et al. Circulating cell-free mRNA in plasma as a tumor marker for patients with primary and recurrent gastric cancer. Anticancer Res 2007, 27:1207-1212.
11. Miura Norimasa., Osali Yukio., Nagashima Miki., et al. A novel biomarker TERTmRNA is applicable for early detection of hepatoma. BMC Gastroenterol 2010, 10:46.
12. El-Saeed Gehan, El-Bassipmo Maha, El-Saeed Hala, et al. Molecular detection of human telomerase m RNA (hTERT-mRNA) in Egyptian patients with hepatocellular carcinoma. Hepatitis Monthly 2009, 9(2):114-121.
13. Miura N., Maruyama S., Oyama K., et al. Development of a novel assay to quantify serum human telomerase reverse transcriptase messenger RNA and its significance as a tumor marker for hepatocellular carcinoma. Oncology 2007, 72(Suppl 1):45-51.
14. Kim Y.D., Hwang S., Lee Y.J., et al. Preoperative blood human telomerase reverse transcriptase mRNA concentration is not a prognostic factor for resection of hepatocellular carcinoma. Hepatogastroenterology 2012, 59(117):1512-1515.