Persistence: A copacetic and parsimonious hypothesis for the existence of non-inherited resistance to antibiotics

Current Opinion in Microbiology

Volumn 21, Issue , 2014, Pages 18-21

  Levin, Bruce R ^a   Concepción Acevedo, Jeniffer ^a   Udekwu, Klas I ^b  

^a EMORY UNIVERSITY   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL TOXIN; CIPROFLOXACIN; GENTAMICIN; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE; TISB TOXIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTERIAL CELL; BACTERIAL CLEARANCE; BACTERIAL GENETICS; BACTERIAL IMMUNITY; BACTERIAL INFECTION; BACTERIAL SURVIVAL; BIOFILM; CELL DENSITY; CELL DIVISION; CELL SURVIVAL; COMPUTER SIMULATION; DNA REPAIR; DRUG RESPONSE; ESCHERICHIA COLI; IMMUNE RESPONSE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PERSISTENT INFECTION; PHENOTYPIC VARIATION; REVIEW; STAPHYLOCOCCUS AUREUS; BACTERIUM; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MOLECULAR EVOLUTION; MUTATION;

ANTI-BACTERIAL AGENTS; BACTERIA; DRUG RESISTANCE, BACTERIAL; EVOLUTION, MOLECULAR; MICROBIAL SENSITIVITY TESTS; MUTATION;

EID: 84905222366     PISSN: 13695274     EISSN: 18790364     Source Type: Journal    
DOI: 10.1016/j.mib.2014.06.016     Document Type: Review

References (25)

1. Dubnau D., Losick R. Bistability in bacteria. Mol Microbiol 2006, 61:564-572.
2. Gonzalez-Pastor J.E., Hobbs E.C., Losick R. Cannibalism by sporulating bacteria. Science 2003, 301:510-513.
3. Hobby G.L., Meyer K., Chaffee E. Observations on the mechanism of action of penicillin. Exp Biol Med 1942, 50:281-285.
4. Bigger J.W. Treatment of Staphylococcal infections with penicillin. Lancet 1944, 244:497-500.
5. Cohen N.R., Lobritz M.A., Collins J.J. Microbial persistence and the road to drug resistance. Cell Host Microbe 2013, 13:632-642.
6. Sharma S.V., Lee D.Y., Li B., Quinlan M.P., Takahashi F., Maheswaran S., McDermott U., Azizian N., Zou L., Fischbach M.A., et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010, 141:69-80.
7. Gerdes K., Maisonneuve E. Bacterial persistence and toxin-antitoxin loci. Annu Rev Microbiol 2012, 66:103-123.
8. Zhang Y. Persisters, persistent infections and the Yin-Yang model. Emerg Microbes Infect 2014, 3:e3.
9. Lewis K. Persister cells. Annu Rev Microbiol 2010, 64:357-372.
10. Amato S.M., Fazen C.H., Henry T.C., Mok W.W., Orman M.A., Sandvik E.L., Volzing K.G., Brynildsen M.P. The role of metabolism in bacterial persistence. Front Microbiol 2014, 5:70.
11. Allison K.R., Brynildsen M.P., Collins J.J. Heterogeneous bacterial persisters and engineering approaches to eliminate them. Curr Opin Microbiol 2011, 14:593-598.
12. Johnson P.J., Levin B.R. Pharmacodynamics, population dynamics, and the evolution of persistence in Staphylococcus aureus. PLOS Genet 2013, 9:e1003123.
13. Luria S.E., Delbruck M. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 1943, 28:491-511.
14. Dorr T., Vulic M., Lewis K. Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol 2010, 8:e1000317.
15. Wiuff C., Zappala R.M., Regoes R.R., Garner K.N., Baquero F., Levin B.R. Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations. Antimicrob Agents Chemother 2005, 49:1483-1494.
16. Kussell E., Kishony R., Balaban N.Q., Leibler S. Bacterial persistence: a model of survival in changing environments. Genetics 2005, 169:1807-1814.
17. Wakamoto Y., Dhar N., Chait R., Schneider K., Signorino-Gelo F., Leibler S., McKinney J.D. Dynamic persistence of antibiotic-stressed mycobacteria. Science 2013, 339:91-95.
18. Johnsen P.J., Dubnau D., Levin B.R. Episodic selection and the maintenance of competence and natural transformation in Bacillus subtilis. Genetics 2009, 181:1521-1533.
19. Lewis K. Persister cells and the riddle of biofilm survival. Biochemistry (Mosc) 2005, 70:267-274.
20. Wang X., Wood T.K. Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response. Appl Environ Microbiol 2011, 77:5577-5583.
21. Levin B.R., Rozen D.E. Non-inherited antibiotic resistance. Nat Rev Microbiol 2006, 4:556-562.
22. Levin B.R., Udekwu K.I. Population dynamics of antibiotic treatment: a mathematical model and hypotheses for time-kill and continuous-culture experiments. Antimicrob Agents Chemother 2010, 54:3414-3426.
23. Regoes R.R., Wiuff C., Zappala R.M., Garner K.N., Baquero F., Levin B.R. Pharmacodynamic functions: a multiparameter approach to the design of antibiotic treatment regimens. Antimicrob Agents Chemother 2004, 48:3670-3676.
24. Ankomah P., Levin B.R. Optomizing the treatment of acute, self-limiting infections: exploring the collaboration between antibiotics and the immune response. PNAS 2014, 111:8331-8338.
25. Conlon B.P., Nakayasu E.S., Fleck L.E., LaFleur M.D., Isabella V.M., Coleman K., Leonard S.N., Smith R.D., Adkins J.N., Lewis K. Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature 2013, 503:365-370.