Activation of Notch signaling is required for cholangiocarcinoma progression and is enhanced by inactivation of p53 in vivo.

PloS one

Volumn 8, Issue 10, 2013, Pages

  El Khatib, Mona ^a   Bozko, Przemyslaw ^b   Palagani, Vindhya ^b   Malek, Nisar P ^b   Wilkens, Ludwig ^b   Plentz, Ruben R ^b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE; ENZYME INHIBITOR; N (N (3,5 DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT BUTYL ESTER; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; PROTEIN P53; SECRETASE;

ANIMAL; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT TUMOR; CELL MOTION; CELL PROLIFERATION; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INFANT; INTRAHEPATIC BILE DUCT; MALE; METABOLISM; MOUSE; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR INVASION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHOLANGIOCARCINOMA; DIPEPTIDES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFANT; MALE; MICE; NEOPLASM INVASIVENESS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84905206968     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077433     Document Type: Article

References (0)