NOD-Rag2null IL-2Rγnull mice: An alternative to NOG mice for generation of humanized mice

Experimental Animals

Volumn 63, Issue 3, 2014, Pages 321-330

  Katano, Ikumi ^a,b   Ito, Ryoji ^a   Kamisako, Tsutomu ^a   Eto, Tomoo ^a   Ogura, Tomoyuki ^a   Kawai, Kenji ^a   Suemizu, Hiroshi ^a   Takahashi, Takeshi ^a   Kawakami, Yutaka ^b   Ito, Mamoru ^a  

^a CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Humanized mice; Immunodeficient mice; NOG mice

Indexed keywords

CD34 ANTIGEN; DNA BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR; RAG2 PROTEIN, MOUSE;

ANIMAL; DEFICIENCY; DISEASE MODEL; FETUS BLOOD; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; NEWBORN; NONOBESE DIABETIC MOUSE; RADIATION DOSE; SCID MOUSE; TRANSPLANTATION; WHOLE BODY RADIATION;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD34; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FETAL BLOOD; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MICE, INBRED NOD; MICE, SCID; RADIATION DOSAGE; RECEPTORS, INTERLEUKIN-2; WHOLE-BODY IRRADIATION;

EID: 84905183997     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.63.321     Document Type: Article

References (18)

1. Bosma, G.C., Fried, M., Custer, R.P., Carroll, A., Gibson, D.M., and Bosma, M.J. 1988. Evidence of functional lymphocytes in some (leaky) scid mice. J. Exp. Med. 167: 1016-1033. [Medline] [CrossRef]
2. Brehm, M.A., Cuthbert, A., Yang, C., Miller, D.M., DiIorio, P., Laning, J., Burzenski, L., Gott, B., Foreman, O., Kavirayani, A., Herlihy, M., Rossini, A.A., Shultz, L.D., and Greiner, D.L. 2010. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin. Immunol. 135: 84-98. [Medline] [CrossRef]
3. Fulop, G.M. and Phillips, R.A. 1990. The scid mutation in mice causes a general defect in DNA repair. Nature 347: 479-482. [Medline] [CrossRef]
4. Hiramatsu, H., Nishikomori, R., Heike, T., Ito, M., Kobayashi, K., Katamura, K., and Nakahata, T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102: 873-880. [Medline] [CrossRef]
5. Ishikawa, F., Yasukawa, M., Lyons, B., Yoshida, S., Miyamoto, T., Yoshimoto, G., Watanabe, T., Akashi, K., Shultz, L.D., and Harada, M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor gamma chain(null) mice. Blood 106: 1565-1573. [Medline] [CrossRef]
6. Ito, M., Hiramatsu, H., Kobayashi, K., Suzue, K., Kawahata, M., Hioki, K., Ueyama, Y., Koyanagi, Y., Sugamura, K., Tsuji, K., Heike, T., and Nakahata, T. 2002. NOD/SCID/ gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100: 3175-3182. [Medline] [CrossRef]
7. Ivanov, I.I., Atarashi, K., Manel, N., Brodie, E.L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K.C., Santee, C.A., Lynch, S.V., Tanoue, T., Imaoka, A., Itoh, K., Takeda, K., Umesaki, Y., Honda, K., and Littman, D.R. 2009. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139: 485-498. [Medline] [CrossRef]
8. Lepus, C.M., Gibson, T.F., Gerber, S.A., Kawikova, I., Szczepanik, M., Hossain, J., Ablamunits, V., Kirkiles-Smith, N., Herold, K.C., Donis, R.O., Bothwell, A.L., Pober, J.S., and Harding, M.J. 2009. Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice. Hum. Immunol. 70: 790-802. [Medline] [CrossRef]
9. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., and Papaioannou, V.E. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68: 869-877. [Medline] [CrossRef]
10. Oettinger, M.A., Stanger, B., Schatz, D.G., Glaser, T., Call, K., Housman, D., and Baltimore, D. 1992. The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. Immunogenetics 35: 97-101. [Medline] [CrossRef]
11. Onoue, M. 1960. Studies on the radiosensitivities of four inbred strains of mice. Jpn. J. Radiol. 19: 2366-2370.
12. Pearson, T., Shultz, L.D., Miller, D., King, M., Laning, J., Fodor, W., Cuthbert, A., Burzenski, L., Gott, B., Lyons, B., Foreman, O., Rossini, A.A., and Greiner, D.L. 2008. Nonobese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin. Exp. Immunol. 154: 270-284. [Medline] [CrossRef]
13. Shinkai, Y., Rathbun, G., Lam, K.P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M., et al. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68: 855-867. [Medline] [CrossRef]
14. Shultz, L.D., Lyons, B.L., Burzenski, L.M., Gott, B., Chen, X., Chaleff, S., Kotb, M., Gillies, S.D., King, M., Mangada, J., Greiner, D.L., and Handgretinger, R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J. Immunol. 174: 6477-6489. [Medline] [CrossRef]
15. Suemizu, H., Yagihashi, C., Mizushima, T., Ogura, T., Etoh, T., Kawai, K., and Ito, M. 2008. Establishing EGFP congenic mice in a NOD/Shi-scid IL2Rg(null) (NOG) genetic background using a marker-assisted selection protocol (MASP). Exp. Anim. 57: 471-477. [Medline] [CrossRef]
16. Traggiai, E., Chicha, L., Mazzucchelli, L., Bronz, L., Piffaretti, J.C., Lanzavecchia, A., and Manz, M.G. 2004. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304: 104-107. [Medline] [CrossRef]
17. Ueda, T., Tsuji, K., Yoshino, H., Ebihara, Y., Yagasaki, H., Hisakawa, H., Mitsui, T., Manabe, A., Tanaka, R., Kobayashi, K., Ito, M., Yasukawa, K., and Nakahata, T. 2000. Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor [In Process Citation]. J. Clin. Invest. 105: 1013-1021. [Medline] [CrossRef]
18. Zhang, B., Duan, Z., and Zhao, Y. 2009. Mouse models with human immunity and their application in biomedical research. J. Cell. Mol. Med. 13: 1043-1058. [Medline] [CrossRef]