Design, synthesis and antimycobacterial evaluation of 1-(4-(2- substitutedthiazol-4-yl)phenethyl)-4-(3-(4-substitutedpiperazin-1-yl)alkyl) piperazine hybrid analogues

European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 605-613

  Nagesh, Hunsur Nagendra ^a   Suresh, Amaroju ^a   Sairam, Sirigina Devesh Sathya Sri ^a   Sriram, Dharmarajan ^a   Yogeeswari, Perumal ^a   Chandra Sekhar, Kondapalli Venkata Gowri ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Alkyl linker; Antimycobacterial activity; Piperazine; Thiazole

Indexed keywords

1 (4 (2 METHYLTHIAZOL 4 YL)PHENETHYL) 4 (3 (4 (2 CHLOROPHENYL)PIPERAZIN 1 YL)PROPYL)PIPERAZINE; 1 (4 (2 METHYLTHIAZOL 4 YL)PHENETHYL) 4 (3 (4 (4 NITROPHENYL)PIPERAZIN 1 YL)PROPYL)PIPERAZINE; 1 (4 (2 METHYLTHIAZOL 4 YL)PHENETHYL) 4 (3 (4 (PYRIDIN 2 YL)PIPERAZIN 1 YL)PROPYL)PIPERAZINE; 1 (4 (2 METHYLTHIAZOL 4 YL)PHENETHYL) 4 (3 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL)PIPERAZINE; 1 (4 (2 METHYLTHIAZOL 4 YL)PHENETHYL) 4 (3 (4 PHENYLPIPERAZIN 1 YL)PROPYL)PIPERAZINE; 4 (4 (2 (4 (3 (4 (2 CHLOROPHENYL)PIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL) N METHYLTHIAZOL 2 AMINE; 4 (4 (2 (4 (3 (4 (2 CHLOROPHENYL)PIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (3 (4 (4 NITROPHENYL)PIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (3 (4 (PYRIDIN 2 YL)PIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (3 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL) N METHYLTHIAZOL 2 AMINE; 4 (4 (2 (4 (3 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (3 (4 PHENYLPIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (4 (4 (2 CHLOROPHENYL)PIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL) N METHYLTHIAZOL 2 AMINE; 4 (4 (2 (4 (4 (4 (2 CHLOROPHENYL)PIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (4 (4 (4 NITROPHENYL)PIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (4 (4 (PYRIDIN 2 YL)PIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (4 (4 BENZHYDRYLPIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL) N METHYLTHIAZOL 2 AMINE; 4 (4 (2 (4 (4 (4 BENZHYDRYLPIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (4 (4 PHENYLPIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; 4 (4 (2 (4 (5 (4 (4 NITROPHENYL)PIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; ANTIMYCOBACTERIAL AGENT; N METHYL 4 (4 (2 (4 (3 (4 (4 NITROPHENYL)PIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; N METHYL 4 (4 (2 (4 (3 (4 (PYRIDIN 2 YL)PIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; N METHYL 4 (4 (2 (4 (3 (4 PHENYLPIPERAZIN 1 YL)PROPYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; N METHYL 4 (4 (2 (4 (4 (4 (4 NITROPHENYL)PIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; N METHYL 4 (4 (2 (4 (4 (4 (PYRIDIN 2 YL)PIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; N METHYL 4 (4 (2 (4 (4 (4 PHENYLPIPERAZIN 1 YL)BUTYL)PIPERAZIN 1 YL)ETHYL)PHENYL)THIAZOL 2 AMINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; 1 [4 (2 METHYLTHIAZOL 4 YL)PHENETHYL] 4 [3 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL]PIPERAZINE; 1 [4 (2 METHYLTHIAZOL 4 YL)PHENETHYL] 4 [3 (4 PHENYLPIPERAZIN 1 YL)PROPYL]PIPERAZINE; 1 [4 (2 METHYLTHIAZOL 4 YL)PHENETHYL] 4 [3 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]PROPYL]PIPERAZINE; 1 [4 (2 METHYLTHIAZOL 4 YL)PHENETHYL] 4 [3 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PROPYL]PIPERAZINE; 1 [4 (2 METHYLTHIAZOL 4 YL)PHENETHYL]4 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL]PIPERAZINE; 4 [4 [2 [4 [3 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]N METHYLTHIAZOL 2 AMINE; 4 [4 [2 [4 [3 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [3 (4 PHENYLPIPERAZIN 1 YL)PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [3 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [3 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [4 (4 BENZHYDRYLPIPERAZIN 1 YL)BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [4 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]N METHYLTHIAZOL 2 AMINE; 4 [4 [2 [4 [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [4 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]N METHYLTHIAZOL 2 AMINE; 4 [4 [2 [4 [4 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [4 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; 4 [4 [2 [4 [5 [4 (4 NITROPHENYL)PIPERAZIN 1 YLPENTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; ISONIAZID; N METHYL 4 [4 [2 [4 [3 (4 PHENYLPIPERAZIN 1 YL)PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; N METHYL 4 [4 [2 [4 [3 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; N METHYL 4 [4 [2 [4 [3 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PROPYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; N METHYL 4 [4 [2 [4 [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; N METHYL 4 [4 [2 [4 [4 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; N METHYL 4 [4 [2 [4 [4 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]BUTYL]PIPERAZIN 1 YL]ETHYL]PHENYL]THIAZOL 2 AMINE; RIFAMPICIN;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ANTIBACTERIAL ACTIVITY; BACTERIAL GROWTH; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG CYTOTOXICITY; DRUG DEVELOPMENT; GROWTH INHIBITION;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905159221     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.067     Document Type: Article

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