The role of corticolimbic circuitry in the development of anxiety disorders in children and adolescents

Current Topics in Behavioral Neurosciences

Volumn 16, Issue , 2014, Pages 133-148

  Swartz, Johnna R ^a   Monk, Christopher S ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Adolescence; Amygdala Prefrontal Cortex; Anxiety Disorder; Development; Emotion Regulation

Indexed keywords

MINERALOCORTICOID RECEPTOR; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ADOLESCENT; AMYGDALOID NUCLEUS; ANXIETY DISORDER; ARTICLE; CELL COMMUNICATION; CHILD; CONNECTOME; CORTICOLIMBIC CIRCUITRY; DEVELOPMENTAL STAGE; DIFFUSION TENSOR IMAGING; EMOTIONALITY; ENVIRONMENTAL FACTOR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MENTAL DISEASE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM PARAMETERS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOSOCIAL ENVIRONMENT; TASK PERFORMANCE; WHITE MATTER; HISTOLOGY; NERVE CELL NETWORK; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ADOLESCENT; AMYGDALA; ANXIETY DISORDERS; CHILD; HUMANS; NERVE NET; PREFRONTAL CORTEX;

EID: 84905120285     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2013_242     Document Type: Article

References (76)

1. Adolphs R (2010) What does the amygdala contribute to social cognition? Ann N Y Acad Sci1191:42–61
2. Ansorge MS, Morelli E, Gingrich JA (2008) Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice. J Neurosci 28(1):199–207
3. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA (2004) Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306:879–881
4. Battaglia M, Zanoni A, Taddei M, Giorda R, Bertoletti E, Lampis V, Scaini S, Cappa S, Tettamanti M (2012) Cerebral responses to emotional expressions and the development of social anxiety disorder: a preliminary longitudinal study. Depression and Anxiety 29(1):54–61
5. Beesdo K, Lau JYF, Guyer AE, McClure-Tone EB, Monk CS, Nelson EE, Fromm SS, Goldwin M, Wittchen H-U, Leibenluft E, Ernst M, Pine DS (2009) Common and distinct amygdala-function perturbations in depressed vs anxious adolescents. Arch Gen Psychiatry66(3):275–285
6. Belsky J, Jonassaint C, Pluess M, Stanton M, Brummett B, Williams R (2009) Vulnerability genes or plasticity genes? Molecular Psychiatry 14(8):746–754
7. Blair KS, Geraci M, Korelitz K, Otero M, Towbin K, Ernst M, Leibenluft E, Blair RJ, Pine DS (2011) The pathology of social phobia is independent of developmental changes in face processing. Am J Psychiatry 168:1202–1209
8. Bogdan R, Wiliamson DE, Hariri AR (2012) Minerlocorticoid receptor iso/val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdale reactivity. Am J Psychiatry 169:515–522
9. Burghy CA, Stodola DE, Ruttle PL, Molloy EK, Armstrong JM, Oler JA, Fox ME, Hayes AS, Kalin NH, Essex MJ, Davidson RJ, Birn RM (2012) Developmental pathways to amygdala-prefrontal function and internalizing symptoms in adolescence. Nat Neurosci 15(12): 1736–1741
10. Casey BJ, Jones RM, Hare TA (2008) The adolescent brain. Ann N Y Acad Sci 1124:111–126
11. Casey BJ, Ruberry EJ, Libby V, Glatt CE, Hare TA, Soliman F, Duhoux S, Frielingsdorf H, Tottenham N (2011) Transitional and translational studies of risk for anxiety. Depression and Anxiety 28:18–28
12. Daws LC, Gould GG (2011) Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacol Ther 131(1):61–79
13. Eluvathingal TJ, Chugani HT, Behen ME, Juhasz C, Muzik O, Maqbool M, Chugani DC, Makki M (2006) Abnormal brain connectivity in children after early severe socioemotional deprivation: A diffusion tensor imaging study. Pediatrics 117(6):2093–2100
14. Ernst M, Mueller SC (2008) The adolescent brain: Insights from functional neuroimaging research. Dev Neurobiol 68:729–743
15. Etkin A, Wager TD (2007) Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 164:1476–1488
16. Fisher PM, Hariri AR (2013) Identifying serotonergic mechanisms underlying the corticolimbic response to threat in humans. Philosophical Trans Roy Soc B 368:1–8
17. Furman DJ, Hamilton JP, Joormann J, Gotlib IH (2011) Altered timing of amygdala activation during sad mood elaboration as a function of 5-HTTLPR. Soc Cogn Affect Neurosci 6(3):270–276
18. Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin: News from mouse molecular genetics. Nat Rev 4:1002–1012
19. Gee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N (2013) A developmental shift from positive to negative connectivity in human amygdala-prefrontal circuitry. J Neurosci 33(10):4584–4593
20. Ghashghaei HT, Hilgetag CC, Barbas H (2007) Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala. Neuroimage34(3):905–923
21. Giedd JN, Rapoport JL (2010) Structural MRI of pediatric brain development: what have we learned and where are we going? Neuron 67(5):728–734
22. Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, Nugent TF 3rd, Herman DH, Clasen LS, Toga AW, Rapoport JL, Thompson PM (2004) Dynamic mapping of human cortical development during childhood through early adulthood. Proc Nat Acad Sci U.S.A.101(21):8174–8179
23. Goldin PR, Manber T, Hakimi S, Canli T, Gross JJ (2009) Neural bases of social anxiety disorder: Emotional reactivity and cognitive regulation during social and physical threat. Arch Gen Psychiatry 66(2):170–180
24. Guyer AE, Lau JYF, McClure-Tone EB, Parrish JM, Shiffrin ND, Reynolds RC, Chen G, Blair RJR, Leibenluft E, Fox NA, Ernst M, Pine DS, Nelson EE (2008a) Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. Arch Gen Psychiatry 65(11):1303–1312
25. Guyer AE, Monk CS, McClure-Tone EB, Nelson EE, Roberson-Nay R, Adler A, Fromm SJ, Leibenluft E, Pine DS, Ernst M (2008b) A developmental examination of amygdala response to facial expressions. J Cognitive Neurosci 20(9):1565–1582
26. Hankin BL, Nederhof E, Oppenheimer CW, Jenness J, Young JF, Abela JRZ, Smolen A, Ormel J, Oldehinkel AJ (2011) Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect for better and worse. Transl Psychiatry 1:e44–e47
27. Hare TA, Tottenham N, Galvan A, Voss HU, Glover GH, Casey BJ (2008) Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task. Biol Psychiatry 63(10):927–934
28. Hariri AR, Weinberger DR (2003) Functional neuroimaging of genetic variation in serotonergic neurotransmision. Genes, Brain Behav 2:341–349
29. Heinz A et al (2005) Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 8(1):20–21
30. Hu X et al (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Human Genet 78:815–826
31. Hyde LW, Bogdan R, Hariri AR (2011a) Understanding risk for psychopathology through imaging gene-environment interactions. Trends Cognitive Sci 15(9):417–427
32. Hyde LW, Gorka A, Manuck SB, Hariri AR (2011b) Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety. Neuropsychologia 49(4): 651–656
33. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:593–602
34. Kim MJ, Whalen PJ (2009) The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety. J Neurosci 29(37):11614–11618
35. Klumpp H, Angstadt M, Nathan PJ, Phan KL (2010) Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study. Psychiatry Res 183(2):167–169
36. Lau JYF et al (2009) Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biol Psychiatry 65(4):349–355
37. Lebel C, Beaulieu C (2011) Longitudinal development of human brain wiring continues from childhood into adulthood. J Neurosci 31(30):10937–10947
38. Lebel C, Walker L, Leemans A, Phillips L, Beaulieu C (2008) Microstructural maturation of the human brain from childhood to adulthood. Neuroimage 40(3):1044–1055
39. Lorberbaum JP et al (2004) Neural correlates of speech anticipatory anxiety in generalized social phobia. NeuroReport 15(18):2701–2705
40. McClure EB et al (2007) Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Arch Gen Psychiatry 64:97–106
41. Milad MR, Quirk GJ (2012) Fear extinction as a model for translational neuroscience: ten years of progress. Ann Rev Psychology 63:129–151
42. Monk CS et al (2003) Adolescent immaturity in attention-related brain engagement to emotional facial expressions. NeuroImage 20:420–428
43. Monk CS et al (2006) Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. Am J Psychiatry 163:1091–1097
44. Monk CS et al (2008) Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry65(5):568–576
45. Munafo MR, Brown SM, Hariri AR (2008) Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 63(9):852–857
46. Nelson EE, Guyer AE (2011) The development of the ventral prefrontal cortex and social flexibility. Dev Cognitive Neurosci 1(3):233–245
47. Nitschke JB, Sarinopoulos I, Oathes DJ, Johnstone T, Whalen PJ, Davidson RJ, Kalin NH (2009) Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 166:302–310
48. Pacheco J, Beevers CG, Benavides C, McGeary J, Stice E, Schnyer DM (2009) Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymoprhism. J Neurosci 29(19):6229–6233
49. Paus T, Keshavan M, Giedd JN (2008) Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci 9:947–957
50. Petrides M, Pandya DN (2002) Association pathways of the prefrontal cortex and functional observations. In: Stuss DT, Knight RT (eds) Principles of Frontal Lobe Function. Oxford University Press, Oxford, pp 31–50
51. Pezawas L et al (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interacations: A genetic susceptibility mechanism for depression. Nat Neurosci 8(6):828–834
52. Pfeifer JH, Allen NB (2012) Arrested development? Reconsidering dual-systems models of brain function in adolescence and disorders. Trends Cognitive Sci 16(6):322–329
53. Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME (2006) Association between amygdale hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol Psychiatry 59(5):424–429
54. Phillips ML, Ladouceur CD, and Drevets WC (2008) A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelop-ment of bipolar disorder. Mol Psychiatry 13(9):829, 833–857
55. Prater KE, Hosanagar A, Klumpp H, Angstadt M, Phan KL (2013) Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder. Depression and Anxiety 30(3):234–241
56. Qin S, Young CB, Supekar K, Uddin LQ, Menon V (2012) Immature integration and segregation of emotion-related brain circuitry in young children. Proc Natl Acad Sci USA 109(20): 7941–7946
57. Ray RD, Zald DH (2012) Anatomical insights into the interaction of emotion and cognition in the prefrontal cortex. Neurosci Biobehav Rev 36(1):479–501
58. Rubia K, Overmeyer S, Taylor E, Brammer M, Williams SCR, Simmons A, Bullmore ET (2000) Functional frontalisation with age: Mapping neurodevelopmental trajectories with fMRI. Neurosci Biobehav Rev 24:13–19
59. Schmidt S, Mohr A, Miltner WHR, Straube T (2010) Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia. Biol Psychol 84(2):304–312
60. Schmithorst VJ, Yuan W (2010) White matter development during adolescence as shown by diffusion MRI. Brain Cogn 72(1):16–25
61. Shah SG, Klumpp H, Angstadt M, Nathan PJ, Phan KL (2009) Amygdala and insula response to emotional images in patients with generalized social anxiety disorder. J Psychiatry Neurosci 34(4):296–302
62. Sibille E, Lewis DA (2006) SERT-ainly involved in depression, but when? Am J Psychiatry163:8–11
63. Somerville LH, Fani N, McClure-Tone EB (2011) Behavioral and neural representation of emotional facial expressions across the lifespan. Dev Neuropsychology 36(4):408–428
64. Somerville LH, Jones RM, Casey BJ (2010) A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive envrionmental cues. Brain Cogn72(1):124–133
65. Stein MB, Goldin PR, Sareen J, Zorrilla TE, Brown GG (2002) Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry59(2002):1027–1034
66. Steinberg L (2005) Cognitive and affective development in adolescence. Trends Cognitive Sci 9(2):69–74
67. Sturman DA, Moghaddam B (2011) The neurobiology of adolescence: changes in brain architecture, functional dynamics, and behavioral tendencies. Neurosci Biobehav Rev 35(8):1704–1712
68. Taddei M, Tettamanti M, Zanoni A, Cappa S, Battaglia M (2012) Brain white matter organization in adolescence is related to childhood cerebral responses to facial expressions and harm avoidance. Neuroimage 61(4):1394–1401
69. Thomas KM et al (2001) Amygdala response to fearful faces in anxious and depressed children. Arch Gen Psychiatry 58:1057–1063
70. Thomason ME, Thompson PM (2011) Diffusion imaging, white matter, and psychopathology. Annu Rev Clin Psychology 7:63–85
71. Troelsen KB, Nielsen EO, Mirza NR (2005) Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter. Psychopharmacology 181:741–750
72. Tromp DPM et al (2012) Reduced structural connectiivty of a major frontolimbic pathway in generalized anxiety disorder. Arch Gen Psychiatry 69(9):925–934
73. White MG, Bogdan R, Fisher PM, Munoz KE, Williamson DE, Hariri AR (2012) FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. Genes, Brain and Behavior 11(7):869–878
74. Wiggins JL, Bedoyan JK, Carrasco M, Swartz JR, Martin DM, and Monk CS (2012) Age-related effect of serotonin transporter genotype on amygdala and prefrontal cortex function in adolescence. Human brain mapping, epub ahead of print
75. Yoon KL, Fitzgerald DA, Angstadt M, McCarron RA, Phan KL (2007) Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study. Psychiatry Res 154(1):93–98Yurgelun-Todd DA (2007) Emotional and cognitive changes during adolescence. Curr Opin Neurobiol 17(2):251–257
76. Yurgelun-Todd DA, Killgore WD (2006) Fear-related activity in the prefrontal cortex increases with age during adolescence: a preliminary fMRI study. Neurosci Lett 406(3):194–199