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Volumn 37, Issue 4, 2014, Pages 404-410

Predictive and prognostic value of the 21-gene recurrence score in hormone receptor-positive, node-positive breast cancer

Author keywords

21 gene recurrence score; Breast cancer; Costeffectiveness; Gene expression profiling; Prognosis

Indexed keywords

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CLINICAL TRIALS, PHASE III AS TOPIC; DISEASE-FREE SURVIVAL; FEMALE; GENETIC MARKERS; HUMANS; NITRILES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RECEPTORS, ESTROGEN; REPRODUCIBILITY OF RESULTS; TAMOXIFEN; TREATMENT OUTCOME; TRIAZOLES; VALIDATION STUDIES AS TOPIC;

EID: 84905107681     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/COC.0000000000000086     Document Type: Review
Times cited : (19)

References (42)
  • 3
    • 84874579353 scopus 로고    scopus 로고
    • The 21-gene Recurrence Score assay impacts adjuvant therapy recommendations for ER-positive, node-negative and node-positive early breast cancer resulting in a risk-adapted change in chemotherapy use
    • Eiermann W, Rezai M, Kümmel S, et al. The 21-gene Recurrence Score assay impacts adjuvant therapy recommendations for ER-positive, node-negative and node-positive early breast cancer resulting in a risk-adapted change in chemotherapy use. Ann Oncol. 2013; 24: 618-624.
    • (2013) Ann Oncol. , vol.24 , pp. 618-624
    • Eiermann, W.1    Rezai, M.2    Kümmel, S.3
  • 5
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005; 365: 1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 6
    • 0036113620 scopus 로고    scopus 로고
    • Can we select which patients with small breast cancers should receive adjuvant chemotherapy?
    • Wood WC, Anderson M, Lyles RH, et al. Can we select which patients with small breast cancers should receive adjuvant chemotherapy? Ann Surg. 2002; 235: 859-862.
    • (2002) Ann Surg. , vol.235 , pp. 859-862
    • Wood, W.C.1    Anderson, M.2    Lyles, R.H.3
  • 7
    • 0035495969 scopus 로고    scopus 로고
    • Prognostic factors in breast cancer: Current and new predictors of metastasis
    • Hayes DF, Isaacs C, Stearns V. Prognostic factors in breast cancer: Current and new predictors of metastasis. J Mammary Gland Biol Neoplasia. 2001; 6: 375-392.
    • (2001) J Mammary Gland Biol Neoplasia. , vol.6 , pp. 375-392
    • Hayes, D.F.1    Isaacs, C.2    Stearns, V.3
  • 8
    • 84856636292 scopus 로고    scopus 로고
    • Comparisons between different polychemotherapy regimens for early breast cancer: Meta-analyses of long-term outcome among 100, 000 women in 123 randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100, 000 women in 123 randomised trials. Lancet. 2012; 379: 432-444.
    • (2012) Lancet , vol.379 , pp. 432-444
  • 9
    • 73249140371 scopus 로고    scopus 로고
    • Prognostic and predictive value of the 21-gene Recurrence Score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: A retrospective analysis of a randomised trial
    • Albain KS, Barlow WE, Shak S, et al. Prognostic and predictive value of the 21-gene Recurrence Score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol. 2010; 11: 55-65.
    • (2010) Lancet Oncol. , vol.11 , pp. 55-65
    • Albain, K.S.1    Barlow, W.E.2    Shak, S.3
  • 10
    • 77951637777 scopus 로고    scopus 로고
    • Prediction of risk of distant recurrence using the 21-gene Recurrence Score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: A TransATAC study
    • Dowsett M, Cuzick J, Wale C, et al. Prediction of risk of distant recurrence using the 21-gene Recurrence Score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study. J Clin Oncol. 2010; 28: 1829-1834.
    • (2010) J Clin Oncol. , vol.28 , pp. 1829-1834
    • Dowsett, M.1    Cuzick, J.2    Wale, C.3
  • 11
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • Ross JS, Hatzis C, Symmans WF, et al. Commercialized multigene predictors of clinical outcome for breast cancer. Oncologist. 2008; 13: 477-493.
    • (2008) Oncologist. , vol.13 , pp. 477-493
    • Ross, J.S.1    Hatzis, C.2    Symmans, W.F.3
  • 12
    • 84864458634 scopus 로고    scopus 로고
    • Clinical validity/utility, change in practice patterns, and economic implications of risk stratifiers to predict outcomes for early-stage breast cancer: A systematic review
    • Hornberger J, Alvarado MD, Rebecca C, et al. Clinical validity/utility, change in practice patterns, and economic implications of risk stratifiers to predict outcomes for early-stage breast cancer: a systematic review. J Natl Cancer Inst. 2012; 104: 1068-1079.
    • (2012) J Natl Cancer Inst. , vol.104 , pp. 1068-1079
    • Hornberger, J.1    Alvarado, M.D.2    Rebecca, C.3
  • 13
    • 70449420123 scopus 로고    scopus 로고
    • Use of archived specimens in evaluation of prognostic and predictive biomarkers
    • Simon RM, Paik S, Hayes DF. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst. 2009; 101: 1446-1452.
    • (2009) J Natl Cancer Inst. , vol.101 , pp. 1446-1452
    • Simon, R.M.1    Paik, S.2    Hayes, D.F.3
  • 14
    • 58149183234 scopus 로고    scopus 로고
    • Chemosensitivity and stratification by a five monoclonal antibody immunohistochemistry test in the NSABP B14 and B20 trials
    • Ross DT, Kim CY, Tang G, et al. Chemosensitivity and stratification by a five monoclonal antibody immunohistochemistry test in the NSABP B14 and B20 trials. Clin Cancer Res. 2008; 14: 6602-6609.
    • (2008) Clin Cancer Res. , vol.14 , pp. 6602-6609
    • Ross, D.T.1    Kim, C.Y.2    Tang, G.3
  • 15
    • 78650892625 scopus 로고    scopus 로고
    • Mammostrat as a tool to stratify breast cancer patients at risk of recurrence during endocrine therapy
    • Bartlett JM, Thomas J, Ross DT, et al. Mammostrat as a tool to stratify breast cancer patients at risk of recurrence during endocrine therapy. Breast Cancer Res. 2010; 12: R47.
    • (2010) Breast Cancer Res. , vol.12
    • Bartlett, J.M.1    Thomas, J.2    Ross, D.T.3
  • 16
    • 33746006844 scopus 로고    scopus 로고
    • Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer
    • Ring BZ, Seitz RS, Beck R, et al. Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer. J Clin Oncol. 2006; 24: 3039-3047.
    • (2006) J Clin Oncol. , vol.24 , pp. 3039-3047
    • Ring, B.Z.1    Seitz, R.S.2    Beck, R.3
  • 17
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
    • Buyse M, Loi S, van't Veer L, et al. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J Natl Cancer Inst. 2006; 98: 1183-1192.
    • (2006) J Natl Cancer Inst. , vol.98 , pp. 1183-1192
    • Buyse, M.1    Loi, S.2    Van't Veer, L.3
  • 18
    • 67649183386 scopus 로고    scopus 로고
    • The 70-gene prognosissignature predicts disease outcome in breast cancer patients with 1-3 positive lymph nodes in an independent validation study
    • Mook S, Schmidt MK, Viale G, et al. The 70-gene prognosissignature predicts disease outcome in breast cancer patients with 1-3 positive lymph nodes in an independent validation study. Breast Cancer Res Treat. 2009; 116: 295-302.
    • (2009) Breast Cancer Res Treat. , vol.116 , pp. 295-302
    • Mook, S.1    Schmidt, M.K.2    Viale, G.3
  • 19
    • 84884762173 scopus 로고    scopus 로고
    • Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy
    • Dowsett M, Sestak I, Lopez-Knowles E, et al. Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy. J Clin Oncol. 2013; 31: 2783-2790.
    • (2013) J Clin Oncol. , vol.31 , pp. 2783-2790
    • Dowsett, M.1    Sestak, I.2    Lopez-Knowles, E.3
  • 20
    • 84885601815 scopus 로고    scopus 로고
    • Identifying clinically relevant prognostic subgroups in node-positive postmenopausal HR+ early breast cancer patients treated with endocrine therapy: A combined analysis of 2485 patients from ABCSG-8 and ATAC using the PAM50 risk of recurrence (ROR) score and intrinsic subtype
    • abstract 506
    • Gnant M, Dowsett M, Filipits M, et al. Identifying clinically relevant prognostic subgroups in node-positive postmenopausal HR+ early breast cancer patients treated with endocrine therapy: a combined analysis of 2485 patients from ABCSG-8 and ATAC using the PAM50 risk of recurrence (ROR) score and intrinsic subtype. J Clin Oncol. 2013; 31(suppl 15): abstract 506.
    • (2013) J Clin Oncol. , vol.31 , Issue.SUPPL. 15
    • Gnant, M.1    Dowsett, M.2    Filipits, M.3
  • 21
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004; 351: 2817-2826.
    • (2004) N Engl J Med. , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 22
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptorpositive breast cancer
    • Paik S, Tang G, Shak S, et al. Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptorpositive breast cancer. J Clin Oncol. 2006; 24: 3726-3734.
    • (2006) J Clin Oncol. , vol.24 , pp. 3726-3734
    • Paik, S.1    Tang, G.2    Shak, S.3
  • 23
    • 33744808550 scopus 로고    scopus 로고
    • A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients
    • Habel LA, Shak S, Jacobs MK, et al. A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients. Breast Cancer Res. 2006; 8: R25.
    • (2006) Breast Cancer Res. , vol.8
    • Habel, L.A.1    Shak, S.2    Jacobs, M.K.3
  • 24
    • 84869049451 scopus 로고    scopus 로고
    • Prognostic impact of the 21-gene Recurrence Score (RS) on disease-free and overall survival of node-positive, ER-positive breast cancer patients (pts) treated with adjuvant chemotherapy: Results from NSABP B-28
    • Abstract 1
    • Mamounas EP, Tang G, Paik S, et al. Prognostic impact of the 21-gene Recurrence Score (RS) on disease-free and overall survival of node-positive, ER-positive breast cancer patients (pts) treated with adjuvant chemotherapy: Results from NSABP B-28. J Clin Oncol. 2012; 30(suppl 27): Abstract 1.
    • (2012) J Clin Oncol. , vol.30 , Issue.SUPPL. 27
    • Mamounas, E.P.1    Tang, G.2    Paik, S.3
  • 25
    • 51649110952 scopus 로고    scopus 로고
    • Prognostic utility of the 21- gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features
    • Goldstein LJ, Gray R, Badve S, et al. Prognostic utility of the 21- gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features. J Clin Oncol. 2008; 26: 4063-4071.
    • (2008) J Clin Oncol. , vol.26 , pp. 4063-4071
    • Goldstein, L.J.1    Gray, R.2    Badve, S.3
  • 26
    • 0037157603 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
    • Baum M, Budzar AU, Cuzick J, et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet. 2002; 359: 2131-2139.
    • (2002) Lancet , vol.359 , pp. 2131-2139
    • Baum, M.1    Budzar, A.U.2    Cuzick, J.3
  • 27
    • 20544434991 scopus 로고    scopus 로고
    • Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: Results from NSABP B-28
    • Mamounas EP, Bryant J, Lembersky B, et al. Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28. J Clin Oncol. 2005; 23: 3686-3696.
    • (2005) J Clin Oncol. , vol.23 , pp. 3686-3696
    • Mamounas, E.P.1    Bryant, J.2    Lembersky, B.3
  • 28
    • 84884710433 scopus 로고    scopus 로고
    • Association between the 21- Gene Recurrence Score (RS) and benefit from adjuvant paclitaxel (Pac) in node-positive (N+), ER-positive breast cancer patients (pts): Results from NSABP B-28
    • abstract
    • Mamounas EP, Tang G, Paik S, et al. Association between the 21- Gene Recurrence Score (RS) and benefit from adjuvant paclitaxel (Pac) in node-positive (N+), ER-positive breast cancer patients (pts): results from NSABP B-28. Cancer Res. 2012; 72(suppl 24): abstract S1-S10.
    • (2012) Cancer Res. , vol.72 , Issue.SUPPL. 24
    • Mamounas, E.P.1    Tang, G.2    Paik, S.3
  • 29
    • 84905088976 scopus 로고    scopus 로고
    • 10-year update of E2197: Phase III doxorubicin/docetaxel (AT) versus doxorubicin/cyclophosphamide (AC) adjuvant treatment of LN + and high-risk LN- breast cancer and the comparison of the prognostic utility of the 21-gene Recurrence Score (RS) with clinicopathologic features
    • abstract 1021
    • Sparano JA, O'Neill A, Gray RJ, et al. 10-year update of E2197: phase III doxorubicin/docetaxel (AT) versus doxorubicin/cyclophosphamide (AC) adjuvant treatment of LN + and high-risk LN- breast cancer and the comparison of the prognostic utility of the 21-gene Recurrence Score (RS) with clinicopathologic features. J Clin Oncol. 2012; 30(Suppl 15): abstract 1021.
    • (2012) J Clin Oncol. , vol.30 , Issue.SUPPL. 15
    • Sparano, J.A.1    O'neill, A.2    Gray, R.J.3
  • 30
    • 84871719398 scopus 로고    scopus 로고
    • SWOG S1007: A phase III randomized clinical trial of standard adjuvant endocrine therapy with or without chemotherapy in patients with one to three positive nodes, hormone receptor (HR)-positive, and HER2-negative breast cancer with Recurrence Score (RS) of 25 or less
    • abstract TPS104
    • Gonzalez-Angulo AM, Barlow WE, Gralow J, et al. SWOG S1007: A phase III randomized clinical trial of standard adjuvant endocrine therapy with or without chemotherapy in patients with one to three positive nodes, hormone receptor (HR)-positive, and HER2-negative breast cancer with Recurrence Score (RS) of 25 or less. J Clin Oncol. 2011; 29(Suppl 15): abstract TPS104.
    • (2011) J Clin Oncol. , vol.29 , Issue.SUPPL. 15
    • Gonzalez-Angulo, A.M.1    Barlow, W.E.2    Gralow, J.3
  • 31
    • 84870570579 scopus 로고    scopus 로고
    • Integrating comparative effectiveness design elements and endpoints into a phase III, randomized clinical trial (SWOG S1007) evaluating Oncotype DX-guided management for women with breast cancer involving lymph nodes
    • Ramsey SD, Barlow WE, Gonzalez-Angulo AM, et al. Integrating comparative effectiveness design elements and endpoints into a phase III, randomized clinical trial (SWOG S1007) evaluating Oncotype DX-guided management for women with breast cancer involving lymph nodes. Contemp Clin Trials. 2012; 34: 1-9.
    • (2012) Contemp Clin Trials. , vol.34 , pp. 1-9
    • Ramsey, S.D.1    Barlow, W.E.2    Gonzalez-Angulo, A.M.3
  • 32
    • 84905096217 scopus 로고    scopus 로고
    • Clinicaltrials.gov. Tamoxifen citrate, letrozole, anastrozole, or exemestane with or without chemotherapy in treating patients with invasive RxPONDER breast cancer. Clinicaltrials.gov identifier NCT01272037, Accessed November 1, 2013
    • Clinicaltrials.gov. Tamoxifen citrate, letrozole, anastrozole, or exemestane with or without chemotherapy in treating patients with invasive RxPONDER breast cancer. Clinicaltrials.gov identifier NCT01272037. Available at: http://clinicaltrials.gov/show/NCT01272037. Accessed November 1, 2013.
  • 33
    • 84905082893 scopus 로고    scopus 로고
    • Impact of the Recurrence Score on adjuvant decision-making in ER-positive early breast cancer-results of a large prospective multicentre decision impact study in node negative and node positive disease
    • abstract P2-12-26
    • Rezai M, Eiermann W, Kümmel S, et al. Impact of the Recurrence Score on adjuvant decision-making in ER-positive early breast cancer-results of a large prospective multicentre decision impact study in node negative and node positive disease. Cancer Res. 2011; 71(suppl 24): abstract P2-12-26.
    • (2011) Cancer Res. , vol.71 , Issue.SUPPL. 24
    • Rezai, M.1    Eiermann, W.2    Kümmel, S.3
  • 34
    • 84870860615 scopus 로고    scopus 로고
    • Australian Decision Impact Study: The impact of Oncotype DX Recurrence Score (RS) on adjuvant treatment decisions in hormone receptor positive (HR +), node negative (N0) and node positive (N +) early stage breast cancer (ESBC) in the multidisciplinary clinic (MDC)
    • abstract P4-09-18
    • de Boer RH, Baker C, Speakman D, et al. Australian Decision Impact Study: the impact of Oncotype DX Recurrence Score (RS) on adjuvant treatment decisions in hormone receptor positive (HR +), node negative (N0) and node positive (N +) early stage breast cancer (ESBC) in the multidisciplinary clinic (MDC). Cancer Res. 2011; 71(suppl 24): abstract P4-09-18.
    • (2011) Cancer Res. , vol.71 , Issue.SUPPL. 24
    • De Boer, R.H.1    Baker, C.2    Speakman, D.3
  • 35
    • 79960168661 scopus 로고    scopus 로고
    • Physician survey of the effect of the 21-gene Recurrence Score assay results on treatment recommendations for patients with lymph node-positive, estrogen receptor-positive breast cancer
    • Oratz R, Kim B, Chao C, et al. Physician survey of the effect of the 21-gene Recurrence Score assay results on treatment recommendations for patients with lymph node-positive, estrogen receptor-positive breast cancer. J Oncol Pract. 2011; 7: 94-99.
    • (2011) J Oncol Pract. , vol.7 , pp. 94-99
    • Oratz, R.1    Kim, B.2    Chao, C.3
  • 36
    • 18444374426 scopus 로고    scopus 로고
    • Economic analysis of targeting chemotherapy using a 21-gene RT-PCR assay in lymphnode- negative, estrogen-receptor-positive, early-stage breast cancer
    • Hornberger J, Cosler LE, Lyman GH. Economic analysis of targeting chemotherapy using a 21-gene RT-PCR assay in lymphnode- negative, estrogen-receptor-positive, early-stage breast cancer. Am J Manag Care. 2005; 11: 313-324.
    • (2005) Am J Manag Care. , vol.11 , pp. 313-324
    • Hornberger, J.1    Cosler, L.E.2    Lyman, G.H.3
  • 37
    • 33947196825 scopus 로고    scopus 로고
    • Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer: An economic analysis based on prognostic and predictive validation studies
    • Lyman GH, Cosler LE, Kuderer NM, et al. Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer: an economic analysis based on prognostic and predictive validation studies. Cancer. 2007; 109: 1011-1018.
    • (2007) Cancer , vol.109 , pp. 1011-1018
    • Lyman, G.H.1    Cosler, L.E.2    Kuderer, N.M.3
  • 38
    • 79960802694 scopus 로고    scopus 로고
    • Cost-effectiveness of 21-gene assay in node-positive, early-stage breast cancer
    • Vanderlaan BF, Broder MS, Chang EY, et al. Cost-effectiveness of 21-gene assay in node-positive, early-stage breast cancer. Am J Manag Care. 2011; 17: 455-464.
    • (2011) Am J Manag Care. , vol.17 , pp. 455-464
    • Vanderlaan, B.F.1    Broder, M.S.2    Chang, E.Y.3
  • 39
    • 80052726134 scopus 로고    scopus 로고
    • US insurance program's experience with a multigene assay for early-stage breast cancer
    • Hornberger J, Chien R, Krebs K, et al. US insurance program's experience with a multigene assay for early-stage breast cancer. J Oncol Pract. 2011; 7: e38s-e45s.
    • (2011) J Oncol Pract. , vol.7
    • Hornberger, J.1    Chien, R.2    Krebs, K.3
  • 40
    • 84855484712 scopus 로고    scopus 로고
    • Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer
    • Hall PS, McCabe C, Stein RC, et al. Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer. J Natl Cancer Inst. 2012; 104: 56-66.
    • (2012) J Natl Cancer Inst. , vol.104 , pp. 56-66
    • Hall, P.S.1    McCabe, C.2    Stein, R.C.3
  • 41
    • 84894092094 scopus 로고    scopus 로고
    • Long-term impact of the 70-gene signature on breast cancer outcome
    • Drukker CA, van Tinteren H, Schmidt MK, et al. Long-term impact of the 70-gene signature on breast cancer outcome. Breast Cancer Res Treat. 2014; 143: 587-592.
    • (2014) Breast Cancer Res Treat. , vol.143 , pp. 587-592
    • Drukker, C.A.1    Van Tinteren, H.2    Schmidt, M.K.3
  • 42
    • 84893424611 scopus 로고    scopus 로고
    • Predicting distant recurrence in receptor-positive breast cancer breast cancer patients with limited clinicopathological risk: Using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone
    • Gnant M, Filipits M, Greil R, et al. Predicting distant recurrence in receptor-positive breast cancer breast cancer patients with limited clinicopathological risk: using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone. Ann Oncol. 2014; 25: 339-345.
    • (2014) Ann Oncol. , vol.25 , pp. 339-345
    • Gnant, M.1    Filipits, M.2    Greil, R.3


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