The role of bronchial epithelial cell apoptosis in the pathogenesis of COPD

Molecular Biology Reports

Volumn 41, Issue 8, 2014, Pages 5321-5327

  Gogebakan, B ^a,b   Bayraktar, R ^b   Ulasli M ^b   Oztuzcu, S ^b   Tasdemir, D ^b   Bayram, H ^b  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Caspases; COPD; p21; p53; Primary bronchial epithelial cells

Indexed keywords

CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE INHIBITOR 1; MESSENGER RNA; PROTEIN P53; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

ADULT; AGED; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CELL CULTURE; CELL DEATH; CELL RENEWAL; CELL VIABILITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; EXPLANT; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; HUMAN CELL; MALE; PATHOGENESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT INFLAMMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKING; BRONCHUS; CYTOLOGY; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; APOPTOSIS; BRONCHI; CASPASE 8; CASPASE 9; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, MESSENGER; SMOKING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84905097328     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-014-3403-3     Document Type: Article

References (31)

1. Goldcopd.org. Global strategy for the diagnosis, management, and prevention of COPD [updated 2013] www.goldcopd.org/uploads/users/files/GOLD- Report-2013-Feb20.pdf
2. Barnes PJ, Shapiro SD, Pauwels RA (2003) Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 22(4):672-688 (Pubitemid 37258549)
3. Demedts IK, Demoor T, Bracke KR, Joos GF, Brusselle GG (2006) Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res 7:53. doi:10.1186/1465-9921-7-53
4. Schrader K, Huai J, Jockel L, Oberle C, Borner C (2010) Non-caspase proteases: triggers or amplifiers of apoptosis? Cell Mol Life Sci 67(10):1607-1618. doi:10.1007/s00018-010-0287-9
5. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM (1998) An induced proximity model for caspase-8 activation. J Biol Chem 273(5):2926-2930 (Pubitemid 28133943)
6. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91(4):479-489 (Pubitemid 27508237)
7. Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE (2001) Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem 276(36):33869-33874. doi:10.1074/jbc.M102225200
8. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90(3):405-413 (Pubitemid 27347231)
9. Szegezdi E, Fitzgerald U, Samali A (2003) Caspase-12 and ER-stress- mediated apoptosis: the story so far. Ann N Y Acad Sci 1010:186-194 (Pubitemid 38264973)
10. Schuler M, Green DR (2001) Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29(Pt 6):684-688 (Pubitemid 33131760)
11. Cmielova J, Rezacova M (2011) p21Cip1/Waf1 protein and its function based on a subcellular localization [corrected]. J Cell Biochem 112(12):3502-3506. doi:10.1002/jcb.23296
12. Huo JX, Metz SA, Li GD (2004) p53-independent induction of p21(waf1/cip1) contributes to the activation of caspases in GTP-depletion-induced apoptosis of insulin-secreting cells. Cell Death Differ 11(1):99-109. doi:10.1038/sj.cdd. 4401322 (Pubitemid 38111377)
13. Bayram H, Ito K, Issa R, Ito M, Sukkar M, Chung KF (2006) Regulation of human lung epithelial cell numbers by diesel exhaust particles. Eur Respir J 27(4):705-713. doi:10.1183/09031936.06.00012805 (Pubitemid 44914192)
14. Puchelle E, Zahm JM, Tournier JM, Coraux C (2006) Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. Proc Am Thorac Soc 3(8):726-733. doi:10.1513/pats.200605- 126SF
15. Imai K, Mercer BA, Schulman LL, Sonett JR, D'Armiento JM (2005) Correlation of lung surface area to apoptosis and proliferation in human emphysema. Eur Respir J 25(2):250-258. doi:10.1183/09031936.05.00023704 (Pubitemid 40246524)
16. Bayram H, Devalia JL, Khair OA, Abdelaziz MM, Sapsford RJ, Sagai M, Davies RJ (1998) Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro. J Allergy Clin Immunol 102(5):771-782
17. Devalia JL, Sapsford RJ, Wells CW, Richman P, Davies RJ (1990) Culture and comparison of human bronchial and nasal epithelial cells in vitro. Respir Med 84(4):303-312 (Pubitemid 20271049)
18. Bayram H, Fakili F, Gogebakan B, Bayraktar R, Oztuzcu S, Dikensoy O, Chung KF (2013) Effect of serum on diesel exhaust particles (DEP)-induced apoptosis of airway epithelial cells in vitro. Toxicol Lett 218(3):215-223. doi:10.1016/j.toxlet.2013.02.006
19. Kuwano K, Araya J, Nakayama K (2008) Epithelial cell fate following lung injury. Expert Rev Respir Med 2(5):573-582. doi:10.1586/17476348.2.5.573
20. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF (2000) Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Investig 106(11):1311-1319. doi:10.1172/JCI10259
21. Kasahara Y, Tuder RM, Cool CD, Voelkel NF (2000) Expression of 15-lipoxygenase and evidence for apoptosis in the lungs from patients with COPD. Chest 117(5 Suppl 1):260S (Pubitemid 30326979)
22. Uhal BD, Joshi I, Hughes WF, Ramos C, Pardo A, Selman M (1998) Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung. Am J Physiol 275(6 Pt 1):1192-1199
23. Calabrese F, Giacometti C, Beghe B, Rea F, Loy M, Zuin R, Marulli G, Baraldo S, Saetta M, Valente M (2005) Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema. Respir Res 6:14. doi:10.1186/1465-9921-6-14
24. Yokohori N, Aoshiba K, Nagai A (2004) Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest 125(2):626-632 (Pubitemid 38223645)
25. Hodge S, Hodge G, Holmes M, Reynolds PN (2005) Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur Respir J 25(3):447-454. doi:10.1183/09031936.05.00077604 (Pubitemid 40331174)
26. Comer DM, Kidney JC, Ennis M, Elborn JS (2013) Airway epithelial cell apoptosis and inflammation in COPD, smokers and nonsmokers. Eur Respir J 41(5):1058-1067. doi:10.1183/09031936.00063112
27. Majo J, Ghezzo H, Cosio MG (2001) Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. Eur Respir J 17(5):946-953 (Pubitemid 32600344)
28. Slebos DJ, Ryter SW, van der Toorn M, Liu F, Guo F, Baty CJ, Karlsson JM, Watkins SC, Kim HP, Wang X, Lee JS, Postma DS, Kauffman HF, Choi AM (2007) Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. Am J Respir Cell Mol Biol 36(4):409-417. doi:10.1165/rcmb.2006-0214OC (Pubitemid 46622998)
29. Siganaki M, Koutsopoulos AV, Neofytou E, Vlachaki E, Psarrou M, Soulitzis N, Pentilas N, Schiza S, Siafakas NM, Tzortzaki EG (2010) Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. Respir Res 11:46. doi:10.1186/1465-9921-11-46
30. Chiappara G, Gjomarkaj M, Virzi A, Sciarrino S, Ferraro M, Bruno A, Montalbano AM, Vitulo P, Minervini MI, Pipitone L, Pace E (2013) The role of p21 Waf1/Cip1 in large airway epithelium in smokers with and without COPD. Biochim Biophys Acta 1832(10):1473-1481. doi:10.1016/j.bbadis.2013.04.022
31. Liedtke C, Groger N, Manns MP, Trautwein C (2003) The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53- dependent mechanism. J Biol Chem 278(30):27593-27604. doi:10.1074/jbc.M304077200 (Pubitemid 36899945)