Analysis of the transcriptome and immune function of monocytes during IFNα-based therapy in chronic HCV revealed induction of TLR7 responsiveness

Antiviral Research

Volumn 109, Issue 1, 2014, Pages 116-124

  Hou, Jun ^a   Groothuismink, Zwier M A ^a   Koning, Ludi ^a   Roomer, Robert ^a   Van Ijcken, Wilfred F J ^a   Kreefft, Kim ^a   Liu, Bi Sheng ^a   Janssen, Harry L A ^a,b   De Knegt, Robert J ^a   Boonstra, Andre ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Gene expression; Interferon; Monocytes; TLR7; Viral hepatitis

Indexed keywords

CD69 ANTIGEN; CD83 ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 1ALPHA; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; PEGINTERFERON ALPHA2A; RIBAVIRIN; TOLL LIKE RECEPTOR 7; TRANSCRIPTOME; ALPHA INTERFERON; ANTIVIRUS AGENT; CYTOKINE; TLR7 PROTEIN, HUMAN;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HEPATITIS C; HUMAN; IN VIVO STUDY; MALE; MIDDLE AGED; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; TREATMENT RESPONSE; UPREGULATION; ADOLESCENT; AGED; DRUG EFFECTS; GENETICS; HEPACIVIRUS; HEPATITIS C, CHRONIC; IMMUNOLOGY; PHYSIOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; CYTOKINES; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; MONOCYTES; TOLL-LIKE RECEPTOR 7; TRANSCRIPTOME; YOUNG ADULT;

EID: 84905032535     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.06.020     Document Type: Article

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