Family-focused treatment for adolescents and young adults at high risk for psychosis: Results of a randomized trial

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 53, Issue 8, 2014, Pages 848-858

  Miklowitz, David J ^a   O'Brien, Mary P ^b   Schlosser, Danielle A ^c   Addington, Jean ^d   Candan, Kristin A ^e   Marshall, Catherine ^d   Domingues, Isabel ^f   Walsh, Barbara C ^b   Zinberg, Jamie L ^a   De Silva, Sandra D ^a   Friedman Yakoobian, Michelle ^g   Cannon, Tyrone D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALGARY   (Canada)

^e ZUCKER HILLSIDE HOSPITAL   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

attenuated psychotic symptoms; early warning signs; family therapy; psychoeducation; schizophrenia

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; MOOD STABILIZER; NEUROLEPTIC AGENT; PSYCHOSTIMULANT AGENT;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CHILD; DETERIORATION; DISEASE SEVERITY; FAMILY FOCUSED THERAPY; FAMILY THERAPY; FEMALE; FOLLOW UP; GENETIC RISK; HIGH RISK POPULATION; HUMAN; INTENTION TO TREAT ANALYSIS; INTERPERSONAL COMMUNICATION; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; OUTCOME ASSESSMENT; POSITIVE SYNDROME; PRIORITY JOURNAL; PROBLEM SOLVING; PSYCHOEDUCATION; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL; SKILL; SOCIAL PSYCHOLOGY; SOCIAL STATUS; STRESS MANAGEMENT; TREATMENT DURATION; CLINICAL TRIAL; CONSUMER HEALTH INFORMATION; CONTROLLED STUDY; EDUCATION; FAMILY RELATION; MULTICENTER STUDY; PROCEDURES; PSYCHOLOGY; PSYCHOTIC DISORDERS; SELF CARE; SOCIAL ADAPTATION; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; CONSUMER HEALTH INFORMATION; EDUCATION, NONPROFESSIONAL; FAMILY RELATIONS; FAMILY THERAPY; FEMALE; HUMANS; MALE; PROBLEM SOLVING; PSYCHOTIC DISORDERS; SELF CARE; SOCIAL ADJUSTMENT; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84905010109     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2014.04.020     Document Type: Article

References (37)

1. T.D. Cannon, K. Cadenhead, and B. Cornblatt et al. Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America Arch Gen Psychiatry 65 2008 28 37
2. P. Fusar-Poli, I. Bonoldi, and A.R. Yung et al. Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk Arch Gen Psychiatry 69 2012 220 229
3. T.H. McGlashan, R.B. Zipursky, and D. Perkins et al. Randomized double-blind clinical trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis Am J Psychiatry 163 2006 790 799
4. P.D. McGorry, A.R. Yung, and L.J. Phillips et al. Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms Arch Gen Psychiatry 59 2002 921 928
5. G.P. Amminger, M.R. Schäfer, and K. Papageorgiou et al. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial Arch Gen Psychiatry 67 2010 146 154
6. M.R. Stafford, H. Jackson, E. Mayo-Wilson, A.P. Morridson, and T. Kendall Early interventions to prevent psychosis: systematic review and meta-analysis BMJ 346 2013 f185
7. A.P. Morrison, P. French, and S.L. Stewart et al. Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial BMJ 344 2012 e2233
8. D.A. Schlosser, J.L. Zinberg, and R.L. Loewy et al. Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis Schizophr Res 118 2010 69 75
9. W.R. McFarlane, and W.L. Cook Family expressed emotion prior to onset of psychosis Fam Process 46 2007 185 197
10. D.J. Miklowitz The role of family systems in severe and recurrent psychiatric disorders: a developmental psychopathology view Dev Psychopathol 16 2004 667 688
11. D.J. Miklowitz, and J. Scott Psychosocial treatments for bipolar disorder: cost-effectiveness, mediating mechanisms, and future directions Bipolar Disord 11 2009 110 122
12. D.J. Miklowitz, D.A. Axelson, and B. Birmaher et al. Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trial Arch Gen Psychiatry 65 2008 1053 1061
13. D.J. Miklowitz, C.D. Schneck, and M.K. Singh et al. Early intervention for symptomatic youth at risk for bipolar disorder: a randomized trial of family-focused therapy J Am Acad Child Adol Psychiatry 52 2013 121 131
14. J. Addington, K.S. Cadenhead, and B.A. Cornblatt et al. North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitment Schizophr Res 142 2012 77 82
15. T.J. Miller, T.H. McGlashan, and J.L. Rosen et al. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of inter-rater reliability and predictive validity Am J Psychiatry 159 2002 863 865
16. K.A. Hawkins, T.H. McGlashan, and D. Quinlan et al. Factorial structure of the Scale of Prodromal Symptoms Schizophr Res 68 2004 339 347
17. R. Hall Global Assessment of Functioning: a modified scale Psychosomatics 36 1995 267 275
18. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (Text Revision) (DSM-IV-TR). Washington, DC: American Psychiatric Press; 2000.
19. M.B. First, R.L. Spitzer, M. Gibbon, and J.B.W. Williams Structured Clinical Interview for DSM-IV Axis I Disorders 1995 New York State Psychiatric Institute, Biometrics Research Department New York
20. J. Addington, K.S. Cadenhead, and T.D. Cannon et al. North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research Schizophr Bull 33 2007 665 672
21. B.A. Cornblatt, A.M. Auther, and T. Niendam et al. Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia Schizophr Bull 33 2007 688 702
22. C.B. Begg, and B. Iglewicz A treatment allocation procedure for sequential clinical trials Biometrics 36 1980 81 90
23. A.G. Weisman, S. Okazaki, and J. Gregory et al. Evaluating therapist competency and adherence to behavioral family management with bipolar patients Fam Process 37 1998 107 121
24. S.E. Marvin, D.J. Miklowitz, M.P. O'Brien, and T.D. Cannon Family-focused therapy for individuals at clinical high risk of psychosis: treatment fidelity within a multisite randomized trial Early Interv Psychiatry 2014 Apr 11 http://dx.doi.org/10.1111/eip. 12144
25. D. Ger, and B.S. Everitt Handbook of Statistical Analyses Using SAS Second Edition 2001 CRC Press London
26. R.P. Liberman Recovery from Disability: Manual for Psychiatric Rehabilitation 2008 American Psychiatric Publishing Washington, DC
27. J. Addington, I. Epstein, L. Liu, P. French, K.M. Boydell, and R.B. Zipursky A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis Schizophr Res 125 2011 54 61
28. T.H. McGlashan, R.B. Zipursky, and D. Perkins et al. Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis Am J Psychiatry 163 2006 790 799
29. A.P. Morrison, P. French, and L. Walford et al. Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial Br J Psychiatry 185 2004 291 297
30. A.R. Yung, L.J. Phillips, and B. Nelson et al. Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysis J Clin Psychiatry 72 2011 430 440
31. S. Dimidjian, S.D. Hollon, and K.S. Dobson et al. Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression J Consult Clin Psychol 74 2006 658 670
32. M.P. O'Brien, D.J. Miklowitz, and T.D. Cannon A randomized trial of family focused therapy with youth at clinical high risk for psychosis: effects on interactional behavior J Consult Clin Psychol 82 2014 90 101
33. D.J. Miklowitz, and S.L. Johnson Social and familial risk factors in bipolar disorder: basic processes and relevant interventions Clin Psychol Sci Pract 16 2009 281 296
34. E.Y. Kim, D.J. Miklowitz, A. Biuckians, and K. Mullen Life stress and the course of early-onset bipolar disorder J Affect Disord 99 2007 37 44
35. D.L. Chambless, and S.D. Hollon Treatment validity for intervention studies H. Cooper, K. Sher, P. Camic, R. Gonzalez, D. Long, A. Panter, APA Handbook of Research Methods in Psychology 2012 American Psychological Association Washington, DC 1 24
36. S.D. Hollon, R.F. Muñoz, and D.H. Barlow et al. Psychosocial intervention development for the prevention and treatment of depression: promoting innovation and increasing access Biol Psychiatry 52 2002 610 630
37. R. Warner The prevention of schizophrenia: what interventions are safe and effective? Schizophr Bull 27 2001 551 562