Risk of bias in randomized trials of pharmacological interventions in children and adults

Journal of Pediatrics

Volumn 165, Issue 2, 2014, Pages

  Sinha, Yashwant K ^a   Craig, Jonathan C ^a,b   Sureshkumar, Premala ^a   Hayen, Andrew ^c   Brien, Jo Anne E ^d,e  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; CHILD; DRUG CLASSIFICATION; EUROPE; HUMAN; OUTCOME ASSESSMENT; PHARMACEUTICAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SENSITIVITY ANALYSIS; STATISTICAL BIAS;

ADULT; BIAS (EPIDEMIOLOGY); CHILD; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT;

EID: 84904991852     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2014.03.058     Document Type: Article

References (13)

1. T.P. Klassen, L. Hartling, J.C. Craig, and M. Offringa Children are not just small adults: the urgent need for high-quality trial evidence in children PLoS Med 5 2008 e172
2. E. Cohen, R.D. Goldman, and A. Ragone et al. Child vs adult randomized controlled trials in specialist journals: a citation analysis of trends, 1985-2005 Arch Pediatr Adolesc Med 164 2010 283 288
3. C. Martinez-Castaldi, M. Silverstein, and H. Bauchner Child versus adult research; the gap in high quality study design Pediatrics 122 2008 52 57
4. H. Shirkey Editorial Comment: Therapeutic Orphans Pediatrics 104 1999 583
5. J.P.T. Higgins, D.G. Altman, and Jonathan AC. Sterne Assessing risk of bias in included studies J.P.T. Higgins, S. Green, Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] 2011 The Cochrane Collaboration www.cochrane-handbook.org Accessed April 4, 2014
6. M.T. Crocetti, D.D. Amin, and R. Scherer Assessment of risk of bias among pediatric randomized controlled trials Pediatrics 126 2010 298 305
7. S. Schroter, P. Glasziou, and C. Heneghan Quality of descriptions of treatments: a review of published randomised controlled trials BMJ Open 2 2012 e001978
8. L. Hartling, M. Ospina, and Y. Liang et al. Risk of bias versus quality assessment of randomised controlled trials: cross sectional study BMJ 339 2009 b4012
9. T. McGinn, P.C. Wyer, T.B. Newman, S. Keitz, R. Leipzig, and G. Guyatt Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic) CMAJ 171 2004 1369 1373
10. L. Wood, M. Egger, and L.L. Gluud et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study BMJ 336 2008 601 605
11. D. Thomson, L. Hartling, E. Cohen, B. Vandermeer, L. Tjosvold, and T.P. Klassen Controlled trials in children: quantity, methodological quality and descriptive characteristics of pediatric controlled trials published 1948-2006 PLoS One 5 2010 e13106
12. K.N. Aripin, I. Choonara, and H.M. Sammons A systematic review of paediatric randomised controlled drug trials published in 2007 Arch Dis Child 95 2010 469 473
13. E. Cohen, E. Uleryk, M. Jasuja, and P.C. Parkin An absence of pediatric randomized controlled trials in general medical journals J Clin Epidemiol 60 2007 118 123