Plant biology informs drug discovery

Nature Reviews Molecular Cell Biology

Volumn 15, Issue 8, 2014, Pages 501-

  Rape, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUXIN; F BOX PROTEIN; INDOLEACETIC ACID; THALIDOMIDE; TRANSPORT INHIBITOR RESPONSE 1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

APOPTOSIS; BIOMEDICINE; CANCER CHEMOTHERAPY; DRUG DEVELOPMENT; DRUG MECHANISM; EMBRYOLOGY; HUMAN; MEDICINAL PLANT; NOTE; PLANT BIOLOGY; PLANT GROWTH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; ARABIDOPSIS; ARABIDOPSIS PROTEINS; CARRIER PROTEINS; F-BOX PROTEINS; INDOLEACETIC ACIDS; RECEPTORS, CELL SURFACE; UBIQUITIN-PROTEIN LIGASES;

EID: 84904982281     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm3842     Document Type: Note

References (5)

1. .Dharmasiri, N., Dharmasiri, S. & Estelle, M. The F-box protein TIR1 is an auxin receptor. Nature 435, 441-445 (2005 (Pubitemid 40734235)
2. Tan, X. et al. Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature 446, 640-645 (2007 (Pubitemid 46606890)
3. Ito, T. et al. Identification of a primary target of thalidomide teratogenicity. Science 327, 1345-1350 (2010
4. Krönke, J. et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 343, 301-305 (2014
5. Lu, G. et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science 343, 305-309 (2014