Toxic epidermal necrolysis in a patient receiving vemurafenib for treatment of metastatic malignant melanoma

British Journal of Dermatology

Volumn 170, Issue 4, 2014, Pages 997-999

  Sinha, R ^a   Lecamwasam, K ^a   Purshouse, K ^b   Reed, J ^b   Middleton, M R ^b   Fearfield, L ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CLOBETASOL PROPIONATE; CLOBETASONE BUTYRATE; IMMUNOGLOBULIN; LIQUID PARAFFIN; NYSTATIN; OXYTETRACYCLINE; VALPROIC ACID; VEMURAFENIB; INDOLE DERIVATIVE; SULFONAMIDE;

AGED; ASSISTED VENTILATION; BLISTER; CANCER SURGERY; CASE REPORT; CLINICAL EXAMINATION; EPITHELIZATION; EXCISION; FEMALE; FEVER; GENE MUTATION; HISTOLOGY; HUMAN; HYPOTENSION; ILLNESS SEVERITY SCORE; LETTER; LYMPH NODE DISSECTION; MECHANICAL VENTILATOR; MEDICAL SPECIALIST; MELENA; METASTATIC MELANOMA; MULTIPLE ORGAN FAILURE; ORAL MUCOSITIS; PNEUMONIA; PRIORITY JOURNAL; RASH; SCORING SYSTEM; SEIZURE; SKIN EXFOLIATION; TACHYCARDIA; TERTIARY CARE CENTER; TOXIC EPIDERMAL NECROLYSIS; VAGINA ATROPHY; FATALITY; MELANOMA; METASTASIS; SKIN NEOPLASMS; STEVENS-JOHNSON SYNDROME;

AGED; FATAL OUTCOME; FEMALE; HUMANS; INDOLES; MELANOMA; NEOPLASM METASTASIS; SKIN NEOPLASMS; STEVENS-JOHNSON SYNDROME; SULFONAMIDES;

EID: 84904962894     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.12796     Document Type: Letter

References (4)

1. Chapman PB, Hauschild A, Robert C, et al,. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364: 2507-16.
2. Sinha R, Edmonds K, Newton-Bishop JA, et al,. Cutaneous adverse events associated with vemurafenib in patients with metastatic melanoma: practical advice on diagnosis, prevention and management of the main treatment-related skin toxicities. Br J Dermatol 2012; 167: 987-94.
3. Bastuji-Garin S, Fouchard N, Bertocchi M, et al,. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 2000; 115: 149-53.
4. Schwartz RA, McDonough PH, Lee BW,. Toxic epidermal necrolysis: Part I. Introduction, history, classification, clinical features, systemic manifestations, etiology, and immunopathogenesis. J Am Acad Dermatol 2013; 69: e1-13.