Applications of nanoparticles in nanomedicine

Journal of Biomedical Nanotechnology

Volumn 10, Issue 9, 2014, Pages 2371-2392

  Yohan, Darren ^a   Chithrani, B Devika ^a  

^a RYERSON UNIVERSITY   (Canada)

Author keywords

Diagnostics; Drug delivery; Gold nanoparticles; Multifunctional nanoparticles; Nanomedicine; Therapy, imaging

Indexed keywords

DIAGNOSIS; GOLD NANOPARTICLES; MEDICAL APPLICATIONS; MEDICAL IMAGING; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; OPTICAL PROPERTIES; PLASMA DIAGNOSTICS;

MULTI-FUNCTIONAL NANOPARTICLES; SCIENTIFIC RESEARCHES; SINGLE NANOPARTICLE;

DRUG DELIVERY;

CONTRAST MEDIUM; FERRIC FERROCYANIDE; GOLD NANOPARTICLE; LANTHANIDE; MACROGOL; MAGNETIC NANOPARTICLE; NANOPARTICLE; NANOROD; POLYACRYLAMIDE; POLYGLACTIN; RADIOSENSITIZING AGENT;

CHEMILUMINESCENCE IMMUNOASSAY; CHEMILUMINESCENCE RESONANCE ENERGY TRANSFER; COLORIMETRY; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; ELECTROMAGNETIC RADIATION; GENE DELIVERY SYSTEM; HUMAN; MICROSCOPY; NANOMEDICINE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTOACOUSTIC TOMOGRAPHY; PHOTOACOUSTICS; PHOTODYNAMIC THERAPY; PHOTOLUMINESCENCE; RADIOSENSITIZATION; REVIEW; ANIMAL; BIOASSAY; DIAGNOSTIC USE; PROCEDURES; ULTRASTRUCTURE;

ANIMALS; BIOLOGICAL ASSAY; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEMS; HUMANS; NANOMEDICINE; NANOPARTICLES;

EID: 84904891640     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.2015     Document Type: Review

References (258)

1. T. M. Allen, P. Sapra, E. Moase, J. Moreira, and D. Iden, Adventures in targeting. J. Liposome Res. 12, 5 (2002).
2. J. M. Anderson and M. S. Shive, Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv. Drug Deliv. Rev. 28, 5 (1997).
3. A. Anshup, J. S. Venkataraman, C. Subramaniam, R. R. Kumar, S. Priya, T. R. S. Kumar, R. V. Omkumar, A. John, and T. Pradeep, Growth of gold nanoparticles in human cells. Langmuir 21, 11562 (2005).
4. M. A. Arnida and H. Ghandehari, Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: A comparative study of rods and spheres. J. Appl. Toxicol. 30, 212 (2009).
5. J. M. Bergen, H. A. van Recum, T. T. Goodman, A. P. Massey, and S. H. Pun, Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery. Macromol. Biosci. 6, 506 (2006).
6. B. K. Bindhani, U. K. Parida, S. K. Biswal, A. K. Panigrahi, and P. L. Nayak, Gold nanoparticles and their biomedical applications. Rev. Nanosci. Nanotechnol. 2, 247 (2013).
7. K. T. Butterworth, J. A. Coulter, S. Jain, J. Forker, S. J. McMahon, G. Schettino, K. M. Prise, F. J. Currell, and D. G. Hirst, Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: Potential application for cancer therapy. Nanotechnology 21, 295101 (2010).
8. J. Chen, F. Saeki, B. J. Wiley, H. Cang, M. J. Cobb, Z. Li, L. Au, H. Zhang, M. B. Kimmey, X. Li, and Y. Xia, Gold nanocages: Bioconjugation and their potential use as optical imaging contrast agents. Nano Lett. 5, 473 (2005).
9. J. Chen, D. Wang, J. Xi, L. Au, A. Siekkinen, A. Warsen, Z. Y. Li, H. Zhang, Y. Xia, and X. Li, Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett. 7, 1318 (2007).
10. D. Chithrani, R. L. Williams, J. Lefebvre, P. J. Poole, and G. C. Aers, Optical spectroscopy of single InAs/InP quantum dots around l = 1.55 mm. Physica E 21, 290 (2004).
11. D. Chithrani, R. L. Williams, J. Lefebvvre, P. J. Poole, and G. C. Aers, Optical spectroscopy of single, site-selected inas/inp self-assembled quantum dots. Appl. Phys. Lett. 84, 978 (2004).
12. D. Chithrani, D. Perovic, R. L. Williams, J. Lefebvvre, P. J. Poole, and G. C. Aers, Electron microscopy and optical spectroscopy of single InAs/InP quantum dots. Spring Proc. Phys. 4, 247 (2005).
13. A. M. Gobin, M. H. Lee, N. J. Halas, W. D. James, R. A. Drezek, and J. L. West, Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. Nano Lett. 7, 1929 (2007).
14. D. Evers, B. Hendriks, G. Lucassen, and T. Ruers, Optical spectroscopy: Current advances and future applications in cancer diagnostics and therapy. Future Oncol. 8, 307 (2012).
15. A. W. Lin, N. A. Lewinski, J. L. West, N. J. Halas, and R. A. Drezek, Optically tunable nanoparticle contrast agents for early cancer detection: Model-based analysis of gold nanoshells. J. Biomed. Opt. 10 (2005).
16. J. L. West, R. Drezek, S. Sershen, and N. J. Halas, Optically-absorbing nanoparticles for enhanced tissue repair, US Patent US6685730B2 (2004).
17. J. Zhu, T. Gong, A. Kopwitthaya, R. Hu, W. Law, I. Roy, H. Huang, and K. Yong, Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging. RSC Adv. 3, 12280 (2013).
18. J. Turkevich, J. Hillier, and P. C. Stevenson, A study of the nucleation and growth processes in the synthesis of colloidal gold. Discuss. Faraday Soc. 11, 55 (1951).
19. T. Yasukawa, H. Miyamura, and S. Kobayashi, Chiral metal nanoparticle-catalyzed asymmetric C-C bond formation reactions. Chem. Soc. Rev. 43, 1450 (2014).
20. J. Chen, J. M. McLellan, A. Siekkinen, Y. Xiong, Z. Y. Li, and Y. Xia, Facile synthesis of gold-silver nanocages with controllable pores on the surface. J. Am. Chem. Soc. 128, 14776 (2006).
21. G. Carrot, J. C. Valmalette, C. J. G. Plummer, S. M. Scholz, J. Dutta, H. Hofmann, and J. G. Hilborn, Gold nanoparticle synthesis in graft copolymer micelles. Colloid Polym. Sci. 276, 853 (1998).
22. B. B. Lakshmi and M. C. C. J. Patrissi, Sol-gel template synthesis of semiconductor oxide micro- and nanostructures. Chem. Mater. 9, 2544 (1997).
23. R. J. Rayavarapu, W. Petersen, C. Ungureanu, J. N. Post, T. G. V. Leeuwen, and S. Manohar, Synthesis and bioconjugation of gold nanoparticles as potential probes for light-based imaging techniques. Int. J. Biomed. Imaging 2007, 1 (2007).
24. C. B. Murray, C. R. Kagan, and M. G. Bawendi, Synthesis and characterization of monodisperse nanocrystal assemblies. Annu. Rev. Mater. Sci. 30, 545 (2000).
25. Y. Liu, M. K. Shipton, J. Ryan, E. D. Kaufman, S. Franzen, and D. L. Feldheim, Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide-poly(ethylene glycol) monolayers. Anal. Chem. 79, 2221 (2007).
26. C. R. Martin, Template synthesis of electronically conductive polymer nanostructures. Acc. Chem. Res. 28, 61 (1995).
27. H. S. Nalwa (ed.), Encyclopedia of Nanoscience and Nanotechnology, American Scientific Publishers, Los Angeles, CA (2004/2011), Vol. 1.
28. H. S. Nalwa (ed.), Handbook of Nanostructured Materials and Nanotechnology, Academic Press, San Diego, CA (2000), Vol. 1.
29. R. Shukla, V. Bansal, M. Chaudhary, A. Basu, R. R. Bhonde, and M. Sastry, Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview. Langmuir 21, 10644 (2005).
30. Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging. Nanoscale 5, 4462 (2013).
31. S. H. Park, S. G. Oh, J. Y. Mun, and S. S. Han, Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities. Colloids Surf., B. 48, 112 (2006).
32. J. Zheng, G. Perkins, A. Kirilova, C. Allen, and D. A. Jaffray, Multimodal contrast agent for combined computed tomography and magnetic resonance imaging applications. Invest. Radiol. 41, 339 (2006).
33. D. Jaffray, C. Allen, J. Zheng, R. M. Reilly, and G. J. Perkins, Compositions and methods for multimodal imaging, US20080206131A1, (2006).
34. B. D. Chithrani, J. Stewart, C. Allen, and D. A. Jaffray, Intracellular uptake, transport, and processing of nanostructures in cancer cells. Nanomedicine 5, 118 (2009).
35. S. Langereis, J. Keupp, J. L. van Velthoven, I. H. de Roos, D. Burdinski, J. A. Pikkemaat, and H. Grull, A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery. J. Am. Chem. Soc. 131, 1380 (2009).
36. H. Ai, J. L. Duerk, C. Flask, J. Gao, J. S. Lewin, X. Shuai, and B. Weinberg, Dual function polymer micelles, US20070253899 (2005).
37. N. Nasongkla, E. Bey, J. Ren, H. Ai, C. Khemtong, J. S. Guthi, S. F. Chin, A. D. Sherry, D. A. Boothman, and J. Gao, Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett. 6, 2427 (2006).
38. Y. Haba, C. Kojima, A. Harada, T. Ura, H. Horinaka, and K. Kono, Preparation of poly(ethylene glycol)-modified poly(amido amine) dendrimers encapsulating gold nanoparticles and their heat-generating ability. Langmuir 23, 5243 (2007).
39. X. Shi, K. Sun, and J. R. Baker, Spontaneous formation of functionalized dendrimer-stabilized gold nanoparticles. J. Phys. Chem. C 112, 8251 (2008).
40. X. Shi, J. R. Baker, and S. Wang, Functionalized dendrimer-encapsulated and dendrimer-stabilized nanoparticles, US20090208580 (2009).
41. D. Y. Kim, T. Yu, E. C. Cho, Y. Ma, O. O. Park, and Y. Xia, Berichtigung: Synthesis of gold nano-hexapods with controllable arm lengths and their tunable optical properties. Angew. Chem. 123, 8120 (2011).
42. M. Colombo, S. Carregal-Romero, M. F. Casula, L. Gutierrez, M. P. Morales, I. B. Bohm, J. T. Heverhagen, D. Prosperi, and W. J. Parak, Biological applications of magnetic nanoparticles. Chem. Soc. Rev. 41, 4306 (2012).
43. J. Chen, J. M. McLellan, A. Siekkinen, Y. Xiong, Z. Li, and Y. Xia, Facile synthesis of gold-silver nanocages with controllable pores on the surface. J. Am. Chem. Soc. 128, 14776 (2006).
44. J. Cheng, Y. J. Gu, S. H. Cheng, and W. T. Wong, Surface functionalized gold nanoparticles for drug delivery. J. Biomed. Nanotechnol. 9, 1362 (2013).
45. N. R. Jana, L. Gearheart, and C. J. Murphy, wet chemical synthesis of high aspect ratio gold nanorods. J. Phys. Chem. B 105, 4065 (2001).
46. L. R. Hirsch, R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, and J. L. West, Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc. Natl. Acad. Sci. USA 100, 13549 (2003).
47. H. Huang, I. H. El-Sayed, W. Qian, and M. A. El-Sayed, Cancer Cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J. Am. Chem. Soc. 128, 2115 (2006).
48. X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Gold nanoparticles: Interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine (Lond) 2, 681 (2007).
49. X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Plasmonic photothermal therapy (PPTT) using gold nanoparticles. Laser Med. Sci. 23, 217 (2008).
50. T. B. Huff, L. Tong, Y. Zhao, M. H. Hansen, J. X. Cheng, and A. Wei, Hyperthermic effects of gold nanorods on tumor cells. Nanomedicine 2, 125 (2007).
51. S. Jelveh and D. B. Chithrani, Gold nanostructures as a platform for combinational therapy in future cancer therapeutics. Cancers 3, 1081 (2011).
52. G. Frens, Controlled nucleation for the particle size in monodisperse gold suspensions. Nature 241, 20 (1973).
53. C. Loo, A. Lowery, N. Halas, J. West, and R. Drezek, Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett. 5, 709 (2005).
54. L. Au, D. Zheng, F. Zhou, Z.-Y. Li, X. Li, and Y. Xia, A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells. ACS Nano 2, 1645 (2008).
55. B. D. Chithrani, A. A. Ghazani, and W. C. Chan, Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 6, 662 (2006).
56. N. Fairbairn, A. Christofidou, A. G. Kanaras, T. A. Newman, and O. L. Muskens, Hyperspectral darkfield microscopy of single hollow gold nanoparticles for biomedical applications. Phys. Chem. Chem. Phys. 15, 4163 (2013).
57. Y. Wang, K. C. Black, H. Luehmann, W. Li, Y. Zhang, X. Cai, D. Wan, S. Y. Liu, M. Li, P. Kim, Z. Y. Li, L. V. Wang, Y. Liu, and Y. Xia, Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. ACS Nano 7, 2068 (2013).
58. P. Li, C. Wei, C. Liao, C. Chen, K. Pao, C. C. Wang, Y. Wu, and D. Shieh, Photoacoustic imaging of multiple targets using gold nanorods. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54, 1642 (2007).
59. E. Fourkal, I. Velchev, A. Taffo, C. Ma, V. Khazak, and N. Skobeleva, Photo-thermal cancer therapy using gold nanorods. IFBME Proc. 25/7, 761 (2009).
60. X. Huang and M. El-Sayed, Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy. J. Adv. Res. 1, 13 (2010).
61. X. Huang and J. Ren, Gold nanoparticles based chemiluminescent resonance energy transfer for immunoassay of alpha fetoprotein cancer marker. Anal. Chim. Acta 686, 115 (2011).
62. L. See, P. Free, Y. Cesbron, P. Nativo, U. Shaheen, D. J. Rigden, D. J. Spiller, D. J. Fernig, M. R. H. White, I. A. Prior, M. Brust, B. Lounis, R. Levy, Cathepsin L digestion of nanobioconjugates upon endocytosis. ACS Nano 3, 2461 (2009).
63. A. G. Tkachenko, H. Xie, Y. Liu, D. Coleman, J. Ryan, W. R. Glomm, M. K. Shipton, S. Franzen, and D. L. Feldheim, Cellular trajectories of peptide-modified gold particle complexes: Comparison of nuclear localization signals and peptide transduction domains. Bioconjug. Chem. 15, 482 (2004).
64. J. A. Ryan, K. W. Overton, M. E. Speight, C. N. Oldenburg, L. Loo, W. Robarge, S. Franzen, and D. L. Feldheim, Cellular uptake of gold nanoparticles passivated with BSA-SV40 large T antigen conjugates. Anal. Chem. 79, 9150 (2007).
65. M. Thomas and A. M. Klibanov, Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc. Natl. Acad. Sci. USA 100, 9138 (2003).
66. H. N. Green, D. V. Martyshkin, C. M. Rodenburg, E. L. Rosenthal, and S. B. Mirov, Gold nanorod bioconjugates for active tumor targeting and photothermal therapy. J. Nanotechnol. 2011 (2011).
67. L. B. Carpin, L. R. Bickford, G. Agollah, T. K. Yu, R. Schiff, Y. Li, and R. A. Drezek, Immunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cells. Breast Cancer Res. Treat. 125, 27 (2011).
68. F. Chen, H. Hong, Y. Zhang, H. F. Valdovinos, S. Shi, G. S. Kwon, C. P. Theuer, T. E. Barnhart, and W. Cai, In vivo tumor targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. ACS Nano 7, 9027 (2013).
69. A. Arnida and H. Ghandehari, Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: A comparative study of rods and spheres. J. Appl. Toxicol. 30, 212 (2010).
70. S. Harrisson and K. L. Wooley, Shell-crosslinked nanostructures from amphiphilic AB and ABA block copolymers of styrene-alt-(maleic anhydride) and styrene: Polymerization, assembly and stabilization in one pot. Chem. Commun. 26, 3259 (2005).
71. R. A. Sperling and W. J. Parak, Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos. Trans. A. Math. Phys. Eng. Sci. 368, 1333 (2010).
72. C. S. Weisbecker, M. V. Merritt, and G. M. Whitesides, Molecular self-assembly of aliphatic thiols on gold colloids. Langmuir 12, 3763 (1996).
73. H. Dollefeld, K. Hoppe, J. Kolny, K. Schilling, H. Weller, and A. Eychmuller, Investigations on the stability of thiol stabilized semiconductor nanoparticles. Phys. Chem. Chem. Phys. 4, 4747 (2002).
74. A. K. Oyelere, P. C. Chen, X. Huang, I. H. El-Sayed, and M. A. El-Sayed, Peptide-conjugated gold nanorods for nuclear targeting. Bioconjug. Chem. 18, 1490 (2007).
75. G. T. Hermanson, Preparation of colloidal-gold-labeled proteins, in Bioconjugate techniques, in Bioconjugate Techniques, Academic Press (1996), p. 593.
76. C. Lu, B. Willner, and I. Willner, DNA nanotechnology: From sensing and DNA machines to drug-delivery systems. ACS Nano 7, 8320 (2013).
77. A. Wijaya, S. B. Schaffer, I. G. Pallares, and K. Hamad-Schifferli, Selective release of multiple DNA oligonucleotides from gold nanorods. ACS Nano 3, 80 (2009).
78. T. S. Hauck, A. A. Ghazani, and W. C. W. Chan, Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells. Small 4, 153 (2007).
79. P. Ruenraroengsak, K. T. Al-Jamala, N. Hartellb, K. Braeckmansc, S. C. De Smedtc, and A. T. Florence, Cell uptake, cytoplasmic diffusion and nuclear access of a 6.5 nm diameter dendrimer. Int. J. Pharm. 331, 215 (2007).
80. A. M. Alkilany, P. K. Nagaria, C. R. Hexel, T. J. Shaw, C. J. Murphy, and M. D. Wyatt, Cellular uptake and cytotoxicity of gold nanorods: Molecular origin of cytotoxicity and surface effects. Small 5, 701 (2009).
81. B. D. Chithrani, M. Dunne, J. Stewart, C. Allen, and D. A. Jaffray, Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier. NanomedicineL NBM 6, 161 (2010).
82. M. Liang, I. Lin, M. R. Whittaker, R. F. Minchin, M. J. Monteiro, and I. Toth, Cellular uptake of densely packed polymer coatings on gold nanoparticles. ACS Nano 4, 403 (2010).
83. J. Davda and V. Labhasetwar, Characterization of nanoparticle uptake by endothelial cells. Int. J. Pharm. 233, 51 (2002).
84. T. B. Huff, M. N. Hansen, Y. Zhao, J. Chen, and A. Wei, Controlling the cellular uptake of gold nanorods. Langmuir 23, 1596 (2007).
85. B. D. Chithrani and W. C. Chan, Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett. 7, 1542 (2007).
86. D. B. Chithrani, Intracellular uptake, transport, and processing of gold nanostructures. Mol. Membr. Biol. 27, 299 (2010).
87. W. Shi, J. Wang, X. Fan, and H. Gao, Size and shape effects on diffusion and absorption of colloidal particles near a partially absorbing sphere: Implications for uptake of nanoparticles in animal cells. Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. 78, 061914 (2008).
88. H. Jin, D. A. Heller, M. S. Strano, R. Sharma, and M. S. Strano, Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes: Single particle tracking and a generic uptake model for nanoparticles. ACS Nano 3, 149 (2009).
89. S. H. Wang, C. W. Lee, A. Chiou, and P. K. Wei, Size-dependent endocytosis of gold nanoparticles studied by three-dimensional mapping of plasmonic scattering images. J. Nanobiotechnology 8, 33 (2010).
90. T. H. Chung, S. H. Wu, M. Yao, C. W. Lu, Y. S. Lin, Y. Hung, C. Y. Mou, Y. C. Chen, and D. M. Huang, The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells. Biomaterials 28, 2959 (2007).
91. M. S. Cartiera, K. M. Johnson, V. Rajendran, M. J. Caplan, and W. M. Salzman, The uptake and Intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 30, 2790 (2009).
92. A. M. Alkilany and C. J. Murphy, Toxicity and cellular uptake of gold nanoparticles: What we have learned so far? J. Nanopart. Res. 12, 2313 (2010).
93. P. Nativo, I. A. Prior, and M. Brust, Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano 2, 1639 (2008).
94. A. Kunzmann, B. Andersson, T. Thurnherr, H. Krug, A. Scheynius, and B. Fadeel, Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation. Biochim. Biophys. Acta 1810, 361 (2011).
95. Y. H. Fu, A. I. Kuznetsov, A. E. Miroshnichenko, Y. F. Yu, and B. Luk/'yanchuk, Directional visible light scattering by silicon nanoparticles. Nat. Commun. 4, 1527 (2013).
96. A. C. Curry, M. Crow, and A. Wax, Molecular imaging of epidermal growth factor receptor in live cells with refractive index sensitivity using dark-field microspectroscopy and immunotargeted nanoparticles. J. Biomed. Opt. 13, 014022 (2008).
97. I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer. Nano Lett. 5, 829 (2005).
98. L. Dykman and N. Khlebtsov, Gold nanoparticles in biomedical applications: Recent advances and perspectives. Chem. Soc. Rev. 41, 2256 (2012).
99. T. Gong, M. Olivo, U. S. Dinish, D. Goh, K. V. Kong, and K. T. Yong, Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells. J. Biomed. Nanotechnol. 9, 985 (2013).
100. L. Josephson, Magnetic Nanoparticles for MR Imaging, edited by M. Ferrari, A. Lee, and L. J. Lee, Springer, US (2006), p. 227.
101. D. E. Sosnovik, M. Nahrendorf, and R. Weissleder, Magnetic nanoparticles for MR imaging: Agents, techniques and cardiovascular applications. Basic Res. Cardiol. 103, 122 (2008).
102. M. Ohgushi, K. Nagayama, and A. Wada, Dextran-magnetite: A new relaxation reagent and its application to T2 measurements in gel systems. J. Magn. Reson. (1969), 29, 599 (1978).
103. W. Chen, D. P. Cormode, Y. Vengrenyuk, B. Herranz, J. E. Feig, A. Klink, W. J. Mulder, E. A. Fisher, and Z. A. Fayad, Collagen-specific peptide conjugated HDL nanoparticles as MRI contrast agent to evaluate compositional changes in atherosclerotic plaque regression. JACC Cardiovasc. Imaging 6, 373 (2013).
104. A. Yilmaz, S. Rosch, K. Klingel, R. Kandolf, X. Helluy, K. H. Hiller, P. M. Jakob, and U. Sechtem, Magnetic resonance imaging (MRI) of inflamed myocardium using iron oxide nanoparticles in patients with acute myocardial infarction-preliminary results. Int. J. Cardiol. 163, 175 (2013).
105. L. Li, W. Jiang, K. Luo, H. Song, F. Lan, Y. Wu, and Z. Gu, Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking. Theranostics 3, 595 (2013).
106. Wertman, Altun, Martin, Mitchell, et al., Risk of nephrogenic systemic fibrosis: Evaluation of gadolinium chelate contrast agents at four American universities. Radiology 248, 799 (2008).
107. Z. Zhao, Z. Zhou, J. Bao, Z. Wang, J. Hu, X. Chi, K. Ni, R. Wang, X. Chen, Z. Chen, and J. Gao, Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging. Nat. Commun. 4 (2013).
108. B. Behshid, K. Ahmad, S. Hojjat, V. Sabino, R. Jesus, M. Puerto, and M. Morteza, Gd Substituted Zn-Fe Ferrite Nanoparticles as High T2 MRI Agents, edited by A. Jobbagy, 5th European Conference of the International Federation for Medical and Biological Engineering, Springer, Berlin, Heidelberg (2012), p. 1113.
109. J. Huang, L. Wang, R. Lin, A. Y. Wang, L. Yang, M. Kuang, W. Qian, and H. Mao, Casein-coated iron oxide nanoparticles for high MRI contrast enhancement and efficient cell targeting. ACS Appl. Mater. Interfaces 5, 4632 (2013).
110. J. Wang, Y. Huang, A. E. David, B. Chertok, L. Zhang, F. Yu, and V. C. Yang, Magnetic nanoparticles for MRI of brain tumors. Curr. Pharm. Biotechnol. 13, 2403 (2012).
111. G. Huang, J. Hu, H. Zhang, Z. Zhou, X. Chi, and J. Gao, Highly magnetic iron carbide nanoparticles as effective T2 contrast agents. Nanoscale 6, 726 (2014).
112. Z. Zhou, L. Wang, X. Chi, J. Bao, L. Yang, W. Zhao, Z. Chen, X. Wang, X. Chen, and J. Gao, Engineered iron-oxide-based nanoparticles as enhanced T1 contrast agents for efficient tumor imaging. ACS Nano 7, 3287 (2013).
113. D. Zhu, F. Liu, L. Ma, D. Liu, and Z. Wang, Nanoparticle-based systems for t1-weighted magnetic resonance imaging contrast agents. Int. J. Mol. Sci. 14, 10591 (2013).
114. L. Zeng, W. Ren, J. Zheng, P. Cui, and A. Wu, Ultra Small water-soluble metal-iron oxide nanoparticles as T1-weighted contrast agents for magnetic resonance imaging. Phys. Chem. Chem. Phys. 14, 2631 (2012).
115. W. Xu, K. Kattel, J. Y. Park, Y. Chang, T. J. Kim, and G. H. Lee, Paramagnetic nanoparticle T1 and T2 MRI contrast agents. Phys. Chem. Chem. Phys. 14, 12687 (2012).
116. F. Hu and Y. S. Zhao, Inorganic nanoparticle-based T1 and T1/T2 magnetic resonance contrast probes. Nanoscale 4, 6235 (2012).
117. H. H. Chen, C. Le Visage, B. Qiu, X. Du, R. Ouwerkerk, K. W. Leong, X. Yang, MR imaging of biodegradable polymeric microparticles: A potential method of monitoring local drug delivery. Magn. Reson. Med. 53, 614 (2005).
118. W. J. Mulder, G. J. Strijkers, G. A. van Tilborg, A. W. Griffioen, K. Nicolay, Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging. NMR Biomed. 19, 142 (2006).
119. J. W. M. Bulte, In vivo MRI cell tracking: Clinical studies. AJR Am. J. Roentgenol. 193, 314 (2009).
120. A. J. Cole, A. E. David, J. Wang, C. J. Galban, and V. C. Yang, Magnetic brain tumor targeting and biodistribution of long-circulating PEG-modified, cross-linked starch-coated iron oxide nanoparticles. Biomaterials 32, 6291 (2011).
121. B. Chertok, B. A. Moffat, A. E. David, F. Yu, C. Bergemann, B. D. Ross, and V. C. Yang, Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 29, 487 (2008).
122. J. Huang, L. Wang, R. Lin, A. Y. Wang, L. Yang, M. Kuang, W. Qian, and H. Mao, Casein-coated iron oxide nanoparticles for high MRI contrast enhancement and efficient cell targeting. ACS Appl. Mater. Interfaces 5, 4632 (2013).
123. J. S. Weinstein, C. G. Varallyay, E. Dosa, S. Gahramanov, B. Hamilton, W. D. Rooney, L. L. Muldoon, and E. A. Neuwelt, Superparamagnetic iron oxide nanoparticles: Diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J. Cereb. Blood Flow Metab. 30, 15 (2009).
124. R. Tivony, L. Larush, O. Sela-Tavor, and S. Magdassi, Biomedical Imaging of colorectal cancer by near infrared fluorescent nanoparticles. J. Biomed. Nanotech. 10, 1041 (2014).
125. N. J. Durr, T. Larson, D. K. Smith, B. A. Korgel, K. Sokolov, and A. Ben-Yakar, Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods. Nano Lett. 7, 941 (2007).
126. C. Jiang, T. Zhao, P. Yuan, N. Gao, Y. Pan, Z. Guan, N. Zhou, and Q. Xu, Two-photon induced photoluminescence and singlet oxygen generation from aggregated gold nanoparticles. ACS Appl. Mater. Interfaces 5, 4972 (2013).
127. Z. Guan, N. Gao, X. Jiang, P. Yuan, F. Han, and Q. Xu, Huge enhancement in two-photon photoluminescence of au nanoparticle clusters revealed by single-particle spectroscopy. J. Am. Chem. Soc. 135, 7272 (2013).
128. Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography. Nanotechnology 20, 395102 (2009).
129. J. V. Jokerst, A. J. Cole, D. Van de Sompel, and S. S. Gambhir, Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. ACS Nano 6, 10366 (2012).
130. X. Liang, Z. Deng, L. Jing, X. Li, Z. Dai, C. Li, and M. Huang, Prussian blue nanoparticles operate as a contrast agent for enhanced photoacoustic imaging. Chem. Commun. 49, 11029 (2013).
131. H. Ju, R. A. Roy, and T. W. Murray, Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy. Biomed. Opt. Express 4, 66 (2013).
132. A. Agarwal, S. Huang, M. ODonnell, K. Day, M. Day, N. Kotov, and S. Ashkenazi, Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging. J. Appl. Phys. 102, 064701 (2007).
133. P. Li, C. Wei, C. Liao, C. Chen, K. Pao, C. C. Wang, Y. Wu, and D. Shieh, Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods. Proc SPIE 6, 60860MM (2006).
134. H. J. Parab, H. M. Chen, T. Lai, J. H. Huang, P. H. Chen, R. Liu, M. Hsiao, C. Chen, D. Tsai, and Y. Hwu, Biosensing, Cytotoxicity, and cellular uptake studies of surface-modified gold nanorods. J. Phys. Chem. C 113, 7574 (2009).
135. J. Li, X. Wang, C. Wang, B. Chen, Y. Dai, R. Zhang, M. Song, G. Lv, and D. Fu, The enhancement effect of gold nanoparticles in drug delivery and as biomarkers of drug-resistant cancer cells. Chem. Med. Chem. 2, 374 (2007).
136. A. Ranzoni, G. Sabatte, L. J. van IJzendoorn, and M. W. J. Prins, One-step homogeneous magnetic nanoparticle immunoassay for biomarker detection directly in blood plasma. ACS Nano 6, 3134 (2012).
137. S. Bhatia, J. V. Frangioni, R. M. Hoffman, A. J. Iafrate, and K. Polyak, The challenges posed by cancer heterogeneity. Nat. Biotech. 30, 604 (2012).
138. C. Loo, A. Lowery, N. Halas, J. West, and R. Drezek, Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett. 5, 709. (2005).
139. I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles. Cancer Lett. 239, 129 (2006).
140. M. P. Melancon, W. Lu, Z. Yang, R. Zhang, Z. Cheng, A. M. Elliot, J. Stafford, T. Olson, J. Z. Zhang, and C. Li, In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol. Cancer. Ther. 7, 1730 (2008).
141. R. K. Visaria, R. J. Griffin, B. W. Williams, E. S. Ebbini, G. F. Paciotti, C. W. Song, and J. C. Bischof, Enhancement of tumor thermal therapy using gold nanoparticle-assisted tumor necrosis factor-a delivery. Mol. Cancer. Ther. 5, 1014 (2006).
142. A. de la Escosura-Muniz, C. Sanchez-Espinel, B. Diaz-Freitas, A. Gonzalez-Fernandez, M. Maltez-da Costa, and A. Merkoci, Rapid identification and quantification of tumor cells using an electrocatalytic method based on gold nanoparticles. Anal. Chem. 81, 10268 (2009).
143. E. Hutter and D. Maysinger, Gold-nanoparticle-based biosensors for detection of enzyme activity. Trends Pharmacol. Sci. 34, 497 (2013).
144. Y. Li, H. Schluesener, and S. Xu, Gold nanoparticle-based biosensors. Gold Bulletin 43, 29 (2010).
145. C. M. Li, Y. F. Li, J. Wang, and C. Z. Huang, Optical investigations on ATP-induced aggregation of positive-charged gold nanoparticles. Talanta 81, 1339 (2010).
146. X. Xu, M. S. Han, and C. A. Mirkin, A gold-nanoparticle-based real-time colorimetric screening method for endonuclease activity and inhibition. Angew. Chem. Int. Ed. Engl. 46, 3468 (2007).
147. Y. Huang, S. Zhao, Z. Chen, Y. Liu, and H. Liang, Ultrasensitive endonuclease activity and inhibition detection using gold nanoparticle-enhanced fluorescence polarization. Chem. Commun. 47, 4763 (2011).
148. A. Ambrosi, F. Airo, and A. Merkoci, Enhanced gold nanoparticle based ELISA for a breast cancer biomarker. Anal. Chem. 82, 1151 (2010).
149. D. Aili, R. Selegard, L. Baltzer, K. Enander, and B. Liedberg, Colorimetric protein sensing by controlled assembly of gold nanoparticles functionalized with synthetic receptors. Small 5, 2445 (2009).
150. Q. Cao, H. Yuan, and R. Cai, Homogeneous detection of human IgG by gold nanoparticle probes. J. Wuhan Univ. Technol. Mater. Sci. Ed. 24, 772 (2009).
151. W. Wang, Y. Zhao, and Y. Jin, Gold-nanorod-based colorimetric and fluorescent approach for sensitive and specific assay of disease-related gene and mutation. ACS Appl. Mater. Interfaces 5, 11741 (2013).
152. P. Mukherjee, R. Bhattacharya, P. Wang, L. Wang, S. Basu, J. A. Nagy, A. Atala, D. Mukhopadhyay, and S. Soker, Antiangiogenic properties of gold nanoparticles. Clin. Cancer Res. 11, 3530 (2005).
153. S. Jain, J. A. Coulter, A. R. Hounsell, K. T. Butterworth, S. J. McMahon, W. B. Hyland, M. F. Muir, G. R. Dickson, K. M. Prise, F. J. Currell, J. M. Oâ™Sullivan, and D. G. Hirst, Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Int. J. Radiat. Oncol. Biol. Phys. 79, 531 (2011).
154. B. D. Chithrani, S. Jelveh, F. Jalali, M. Van Prooijen, C. Allen, R. G. Bristow, R. P. Hill, and D. A. Jaffray, Gold nanoparticles as a radiation sensitizer in cancer therapy. Radiat. Res. 173, 719 (2010).
155. P. K. Jain, K. S. Lee, I. El-Sayed, and M. El-Sayed, Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition:? Applications in biological imaging and biomedicine. J. Phys. Chem. B 110, 7238 (2006).
156. S. Link and M. El-Sayed, Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals. Int. Rev. Phys. Chem. 19, 409 (2000).
157. J. Panyam and V. Labhasetwar, Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55, 329 (2003).
158. I. Roy, T. Y. Ohulchanskyy, H. E. Pudavar, E. J. Bergey, A. R. Oseroff, J. Morgan, T. J. Dougherty, and P. N. Prasad, Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: A novel drug-carrier system for photodynamic therapy. J. Am. Chem. Soc. 125, 7860 (2003).
159. M. R. Detty, S. L. Gibson, and S. J. Wagner, Current clinical and preclinical photosensitizers for use in photodynamic therapy. J. Med. Chem. 47, 3897 (2004).
160. Y. Cheng, A. C. Samia, J. D. Meyers, I. Panagopoulos, B. Fei, and C. Burda, Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer. J. Am. Chem. Soc. 130, 10643 (2008).
161. R. Chouikrat, A. Seve, R. Vanderesse, H. Benachour, M. Barberi-Heyob, S. Richeter, L. Raehm, J. O. Durand, M. Verelst, and C. Frochot, Non polymeric nanoparticles for photodynamic therapy applications: Recent developments. Curr. Med. Chem. 19, 781 (2012).
162. R. F. Donnelly, P. A. McCarron, D. I. Morrow, S. A. Sibani, and A. D. Woolfson, Photosensitizer delivery for photodynamic therapy. Expert Opin. Drug Deliv. 5, 757 (2008).
163. W. Chen and J. Zhang, Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment. J. Nanosci. Nanotechnol. 6, 1159 (2006).
164. A. J. Gomes, L. O. Lunardi, J. M. Marchetti, C. N. Lunardi, and A. C. Tedesco, Photobiological and ultrastructural studies of nanoparticles of poly(lactic-co-glycolic acid)-containing bacteriochlorophyll-a as a photosensitizer useful for PDT Treatment. Drug Deliv. 12, 159 (2005).
165. D. Bechet, P. Couleaud, C. Frochot, M. L. Viriot, F. Guillemin, and M. Barberi-Heyob, Nanoparticles as vehicles for delivery of photodynamic therapy agents. Trends Biotechnol. 26, 612 (2008).
166. W. Tang, H. Xu, R. Kopelman, and M. A. Philbert, Photodynamic characterization and in vitro application of methylene blue-containing nanoparticle platforms. Photochem. Photobiol. 81, 242 (2005).
167. Z. Zhen, W. Tang, C. Guo, H. Chen, X. Lin, G. Liu, B. Fei, X. Chen, B. Xu, and J. Xie, Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer. ACS Nano 7, 6988 (2013).
168. J. Lin, S. Wang, P. Huang, Z. Wang, S. Chen, G. Niu, W. Li, J. He, D. Cui, G. Lu, X. Chen, and Z. Nie, Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy. ACS Nano 7, 5320 (2013).
169. B. Tian, C. Wang, S. Zhang, L. Feng, and Z. Liu, Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. ACS Nano 5, 7000 (2011).
170. D. K. Chatterjee, L. S. Fong, and Y. Zhang, Nanoparticles in photodynamic therapy: An emerging paradigm. Adv. Drug Deliv. Rev. 60, 1627 (2008).
171. J. Boyer, F. Vetrone, L. A. Cuccia, and J. A. Capobianco, Synthesis of colloidal upconverting NaYF4 nanocrystals Doped with Er3+, Yb3+ and Tm3+, Yb3+ via thermal decomposition of lanthanide trifluoroacetate precursors. J. Am. Chem. Soc. 128, 7444 (2006).
172. A. M. Pires, S. Heer, H. U. Gudel, and O. A. Serra, Er, Yb doped yttrium based nanosized phosphors: Particle size, host lattice and doping ion concentration effects on upconversion efficiency. J. Fluoresc. 16, 461 (2006).
173. H. J. Zijlmans, J. Bonnet, J. Burton, K. Kardos, T. Vail, R. S. Niedbala, and H. J. Tanke, Detection of cell and tissue surface antigens using up-converting phosphors: A new reporter technology. Anal. Biochem. 267, 30 (1999).
174. X. Wang, J. Zhuang, Q. Peng, and Y. Li, Hydrothermal synthesis of rare-earth fluoride nanocrystals. Inorg. Chem. 45, 6661 (2006).
175. S. Heer, K. Kompe, H. U. Gudel, and M. Haase, Highly efficient multicolour upconversion emission in transparent colloids of lanthanide-doped NaYF4 nanocrystals. Adv. Mater. 16, 2102 (2004).
176. G. Chen, J. Shen, T. Y. Ohulchanskyy, N. J. Patel, A. Kutikov, Z. Li, J. Song, R. K. Pandey, H. Agren, P. N. Prasad, and G. Han, (alpha-NaYbF4:Tm(3+))/ CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano 6, 8280 (2012).
177. S. Cui, D. Yin, Y. Chen, Y. Di, H. Chen, Y. Ma, S. Achilefu, and Y. Gu, In vivo targeted deep-tissue photodynamic therapy based on near-infrared light triggered upconversion nanoconstruct. ACS Nano 7, 676 (2013).
178. C. Wang, L. Cheng, and Z. Liu, Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. Biomaterials 32, 1110 (2011).
179. C. Wang, H. Tao, L. Cheng, and Z. Liu, Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials 32, 6145 (2011).
180. K. Liu, X. Liu, Q. Zeng, Y. Zhang, L. Tu, T. Liu, X. Kong, Y. Wang, F. Cao, S. A. Lambrechts, M. C. Aalders, and H. Zhang, Covalently assembled NIR nanoplatform for simultaneous fluorescence imaging and photodynamic therapy of cancer cells. ACS Nano 6, 4054 (2012).
181. Y. I. Park, H. M. Kim, J. H. Kim, K. C. Moon, B. Yoo, K. T. Lee, N. Lee, Y. Choi, W. Park, D. Ling, K. Na, W. K. Moon, S. H. Choi, H. S. Park, S. Y. Yoon, Y. D. Suh, S. H. Lee, and T. Hyeon, Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy. Adv. Mater. 24, 5755 (2012).
182. L. Au, D. Zheng, F. Zhou, Z. Li, X. Li, and Y. Xia, A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells. ACS Nano 2, 1645 (2008).
183. M. Everts, V. Saini, J. L. Leddon, R. J. Kok, M. Stoff-Khalili, M. A. Preuss, L. C. Millican, G. Perkins, J. M. Brown, H. Bagaria, D. E. Nikles, D. T. Johnson, V. P. Zharov, and D. T. Curiel, Covalently linked Au nanoparticles to a viral vector: Potential for combined photothermal and gene cancer therapy. Nano Lett. 6, 587 (2006).
184. S. Lee, H. J. Kim, Y. Ha, Y. N. Park, S. Lee, Y. Park, and K. Yoo, Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. ACS Nano 7, 50 (2013).
185. W. I. Choi, J. Kim, C. Kang, C. C. Byeon, Y. H. Kim, and G. Tae, Tumor regression in vivo by photothermal therapy based on gold-nanorod-loaded, functional nanocarriers. ACS Nano 5, 1995 (2011).
186. H. Matsudaira, A. M. Ueno, and F. I, Iodine contrast medium sensitizes cultured mammalian cells to X-rays but not to gamma rays. Radiat. Res. 84, 144 (1980).
187. R. S. Mello, H. Callisen, J. Winter, A. R. Kagan, and A. Norman, Radiation dose enhancement in tumors with iodine. Med. Phys. 10, 75 (1983).
188. M. H. Castillo, T. M. Button, R. Doerr, M. I. Homs, C. W. Pruett, and J. I. Pearce, Effects of radiotherapy on mandibular reconstruction plates. Am. J. Surg. 156, 261 (1988).
189. I. J. Das and K. L. Chopra, Backscatter dose perturbation in kilo-voltage photon beams at high atomic number interfaces. Med. Phys. 22, 767 (1995).
190. I. J. Das, Forward dose perturbation at high atomic number interfaces in kilovoltage X-ray beams. Med. Phys. 24, 1781 (1997).
191. A. S. Allal, M. Richter, M. Russo, M. Rouzaud, P. Dulguerov, and J. M. Kurtz, Dose variation at bone/titanium interfaces using titanium hollow screw osseointegrating reconstructive plates. Int. J. Radiat. Oncol. Biol. Phys. 40, 215 (1998).
192. E. Melian, M. Fatyga, P. Lam, M. Steinberg, S. P. Reddy, G. J. Petruzzelli, and G. P. Glasgow, Effect of metal reconstructive plates on cobalt dose distribution: A predictive formula and clinical implications. Int. J. Radiat. Oncol. Biol. Phys. 44, 725 (1999).
193. S. H. Cho, Estimation of tumor dose enhancement due to gold nanoparticles during typical radiation treatments: A preliminary Monte Carlo study. Phys. Med. Biol. 50, N163 (2005).
194. X. A. Li, J. C. Chu, W. Chen, and T. Zusag, Dose enhancement by a thin foil of high-Z material: A Monte Carlo study. Med. Phys. 26, 1245 (1999).
195. D. M. Herold, I. J. Das, C. C. Stobbe, R. V. Iyer, and J. D. Chapman, Gold microspheres: A selective technique for producing biologically effective dose enhancement. Int. J. Radiat. Biol. 76, 1357 (2000).
196. W. Ngwa, H. Korideck, A. I. Kassis, R. Kumar, S. Sridhar, G. M. Makrigiorgos, and R. A. Cormack, In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I brachytherapy seeds. Nanomedicine 9, 25 (2013).
197. E. Brun, L. Sanche, and C. Sicard-Roselli, Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution. Colloids Surf., B 72, 128 (2009).
198. H. Kaur, D. K. Avasthi, G. Pujari, and A. Sarma, Radiosensitizing effect of gold nanoparticles in carbon ion irradiation of human cervical cancer cells. AIP Proc. 1530, 205 (2013).
199. X. Zhang, D. Wu, X. Shen, J. Chen, Y. Sun, P. Liu, and X. Liang, Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy. Biomaterials 33, 6408 (2012).
200. Y. Zheng and L. Sanche, Low energy electrons in nanoscale radiation physics: Relationship to radiosensitization and chemoradiation therapy. Rev. Nanosci. Nanotechnol. 2, 1 (2013).
201. J. Gvili and M. Machluf, 544 PLGA nanoparticles for DNA vaccination-waiving complexity and increasing efficiency. Mol. Ther. 13, S209 (2006).
202. Y. Chen, X. Zhu, X. Zhang, B. Liu, and L. Huang, Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol. Ther. 18, 1650 (2010).
203. S. J. Lee, A. Lee, S. R. Hwang, J. S. Park, J. Jang, M. S. Huh, D. G. Jo, S. Y. Yoon, Y. Byun, S. H. Kim, I. C. Kwon, I. Youn, and K. Kim, TNF-alpha gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis. Mol. Ther. 22, 397 (2013).
204. N. A. McNeer, J. Y. Chin, E. B. Schleifman, R. J. Fields, P. M. Glazer, and W. M. Saltzman, Nanoparticles deliver triplex-forming PNAs for site-specific genomic recombination in CD34+ human hematopoietic progenitors. Mol. Ther. 19, 172 (2011).
205. C. Villiers, H. Freitas, R. Couderc, M. B. Villiers, and P. Marche, Analysis of the toxicity of gold nano particles on the immune system: Effect on dendritic cell functions. J. Nanopart. Res. 12, 55 (2010).
206. N. W. S. Kam, Z. Liu, and H. Dai, Carbon nanotubes as intracellular transporters for proteins and DNA: An investigation of the uptake mechanism and pathway. Angew. Chem. Int. Ed. Engl. 45, 577 (2006).
207. J. Nakanishi, H. Nakayama, T. Shimizu, H. Ishida, Y. Kikuchi, K. Yamaguchi, and Y. Horiike, Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines. J. Am. Chem. Soc. 131, 3822 (2009).
208. J. Suh, D. Wirtz, and J. Hanes, Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking. Biotechnol. Prog. 20, 598 (2004).
209. J. C. Olivier, Drug transport to brain with targeted nanoparticles. NeuroRx 2, 108 (2005).
210. R. Tantra and A. Knight, Cellular uptake and intracellular fate of engineered nanoparticles: A review on the application of imaging techniques. Nanotoxicology 5, 381 (2011).
211. A. Albanese, P. S. Tang, and W. C. Chan, The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu. Rev. Biomed. Eng. 14, 1 (2012).
212. B. Neha, B. Ganesh, and K. Preeti, Drug delivery to the brain using polymeric nanoparticles: A review. Int. J. Pharm. Life Sci. 2, 3 (2013).
213. L. Y. T. Chou, K. Ming, and W. C. W. Chan, Strategies for the intracellular delivery of nanoparticles. Chem. Soc. Rev. 40, 233 (2011).
214. T. Iversen, T. Skotland, and K. Sandvig, Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies. Nano Today 6, 176 (2011).
215. M. Ansari, H. Khan, A. Khan, R. Pal, and S. Cameotra, Antibacterial potential of Al2O3 nanoparticles against multidrug resistance strains of Staphylococcus aureus isolated from skin exudates. J. Nanopart. Res. 15, 1 (2013).
216. H. Haase, A. Fahmi, and B. Mahltig, Impact of silver nanoparticles and silver ions on innate immune cells. J. Biomed. Nanotech. 10, 1146 (2014).
217. A. N. Brown, K. Smith, T. A. Samuels, J. Lu, S. O. Obare, and M. E. Scott, Nanoparticles functionalized with ampicillin destroy multiple-antibiotic- resistant isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and methicillin-resistant Staphylococcus aureus. Appl. Environ. Microbiol. 78, 2768 (2012).
218. M. A. Ansari, H. M. Khan, A. A. Khan, S. S. Cameotra, Q. Saquib, and J. Musarrat, Gum arabic capped-silver nanoparticles inhibit biofilm formation by multi-drug resistant strains of Pseudomonas aeruginosa. J. Basic Microbiol. Epub ahead of print (2014).
219. G. F. Paciotti, L. Myer, D. Weinreich, D. Goia, N. Pavel, R. E. McLaughlin, and L. Tamarkin, Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery. Drug Deliv. 11, 169 (2004).
220. L. Zhang, Y. Zhang, W. Wu, and X. Jiang, Doxorubicin-loaded boron-rich polymer nanoparticles for orthotopically implanted liver tumor treatment. Chin. J. Polym. Sci. 31, 778 (2013).
221. K. Qiu, C. He, W. Feng, W. Wang, X. Zhou, Z. Yin, L. Chen, H. Wang, and X. Mo, Doxorubicin-loaded electrospun poly(l-lactic acid)/mesoporous silica nanoparticles composite nanofibers for potential postsurgical cancer treatment. J. Mater. Chem. B 1, 4601 (2013).
222. G. Han, P. Ghosh, M. De, and V. M. Rotello, Drug and gene delivery using gold nanoparticles. Nanobiotechnology 3, 40 (2007).
223. H. Lee, S. Park, J. B. Kim, J. Kim, and H. Kim, Entrapped doxorubicin nanoparticles for the treatment of metastatic anoikis-resistant cancer cells. Cancer Lett. 332, 110 (2013).
224. B. Duncan, C. Kim, and V. M. Rotello, Gold nanoparticle platforms as drug and biomacromolecule delivery systems. J. Controlled Release 148, 122 (2010).
225. S. D. Brown, P. Nativo, J. Smith, D. Stirling, P. R. Edwards, B. Venugopal, D. J. Flint, J. A. Plumb, D. Graham, and N. J. Wheate, Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J. Am. Chem. Soc. 132, 4678 (2010).
226. A. Yavlovich, B. Smith, K. Guptha, R. Blumenthal, and A. Puri, Light-sensitive lipid-based nanoparticles for drug delivery: Design principles and future considerations for biological applications. Mol. Membr. Biol. 27, 364 (2010).
227. N. Kohler, C. Sun, A. Fichtenholtz, J. Gunn, C. Fang, and M. Zhang, Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery. Small 2, 785 (2006).
228. M. Liong, J. Lu, M. Kovochich, T. Xia, S. G. Ruehm, A. E. Nel, F. Tamanoi, and J. I. Zink, Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2, 889 (2008).
229. E. Turos and J. Shim, Nanoparticles for Drug-delivery, US20070190160, US-patent (2007).
230. J. Panyam and V. Labhasetwar, Sustained cytoplasmic delivery of drugs with intracellular receptors using biodegradable nanoparticles. Mol. Pharm. 1, 77 (2004).
231. C. M. Cobley, L. Au, J. Chen, and Y. Xia, Targeting gold nanocages to cancer cells for photothermal destruction and drug delivery. Expert Opin. Drug Deliv. 7, 577 (2010).
232. H. Jang, S. R. Ryoo, K. Kostarelos, S. W. Han, and D. H. Min, The effective nuclear delivery of doxorubicin from dextran-coated gold nanoparticles larger than nuclear pores. Biomaterials 34, 3503 (2013).
233. J. E. Lee, N. Lee, H. Kim, J. Kim, S. H. Choi, J. H. Kim, T. Kim, I. C. Song, S. P. Park, W. K. Moon, and T. Hyeon, Uniform mesoporous dye-doped silica nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. J. Am. Chem. Soc. 132, 552 (2010).
234. M. Zhou, L. Wang, W. Su, L. Tong, Y. Liu, Y. Fan, N. Luo, Y. Zheng, H. Zhao, R. Xiang, and Z. Li, Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy. J. Biomed. Nanotechnol. 8, 742 (2012).
235. S. C. Coelho, S. Rocha, M. C. Pereira, P. Juzenas, and M. A. N. Coelho, Enhancing proteasome-inhibitor effect by functionalized gold nanoparticles. J. Biomed. Nanotechnol. 10, 717 (2014).
236. B. Yoo, S. K. Ghosh, M. Kumar, A. Moore, M. V. Yigit, and Z. Medarova, Design of nanodrugs for miRNA targeting in tumor cells. J. Biomed. Nanotech. 10, 1114 (2014).
237. Y. Shan, T. Luo, C. Peng, R. Sheng, A. Cao, X. Cao, M. Shen, R. Guo, H. Tomas, and X. Shi, Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. Biomaterials 33, 3025 (2012).
238. G. Bao, S. Mitragotri, and S. Tong, Multifunctional nanoparticles for drug delivery and molecular imaging. Annu. Rev. Biomed. Eng. 15, 253 (2013).
239. W. H. De Jong and P. J. A. Borm, Drug delivry and nanoparticles: Applications and hazards. Int. J. Nanomedicine 3, 133 (2008).
240. A. Z. Wilczewska, K. Niemirowicz, K. H. Markiewicz, and H. Car, Nanoparticles as drug delivery systems. Pharmacol. Rep. 64, 1020 (2012).
241. G. F. Paciotti, L. Myer, D. Weinreich, D. Goia, N. Pavel, R. E. McLaughlin, and L. Tamarkin, Colloidal gold: A novel nanoparticle vector for tumor directed drug delivery. Drug Deliv. 11, 169 (2004).
242. R. B. Greenwald, Y. H. Choe, J. McGuire, and C. D. Conover, Effective drug delivery by PEGylated drug conjugates. Adv. Drug Deliv. Rev. 55, 217 (2003).
243. Y. Zu, S. Huang, W. Liao, Y. Lu, and S. Wang, Gold nanoparticles enhanced electroporation for mammalian cell transfection. J. Biomed. Nanotech. 10, 982 (2014).
244. Z. Wang, L. Jia, and M. H. Li, Gold nanoparticles decorated by amphiphilic block copolymer as efficient system for drug delivery. J. Biomed. Nanotechnol. 9, 61 (2013).
245. T. K. Jain, J. Richey, M. Strand, D. L. Leslie-Pelecky, C. A. Flask, and V. Labhasetwar, Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging. Biomaterials 29, 4012 (2008).
246. E. Morales-Avila, G. Ferro-Flores, B. E. Ocampo-GarcÃa, and L. M. GÃ3mez-Oliván, Engineered multifunctional rgd-gold nanoparticles for the detection of tumour-specific alpha(v)beta(3) expression: Chemical characterisation and ecotoxicological risk assessment. J. Biomed. Nanotechnol. 8, 991 (2012).
247. M. Licciardi, C. Scialabba, G. Cavallaro, C. Sangregorio, E. Fantechi, and G. Giammona, Cell uptake enhancement of folate targeted polymer coated magnetic nanoparticles. J. Biomed. Nanotechnol. 9, 949 (2013).
248. Z. Zhen, W. Tang, H. Chen, X. Lin, T. Todd, G. Wang, T. Cowger, X. Chen, and J. Xie, RGD-modified apoferritin nanoparticles for efficient drug delivery to tumors. ACS Nano 7, 4830 (2013).
249. K. Breitenkamp, K. N. Sill, H. Skaff, and R. Breitenkamp, Polymeric micelles for drug delivery, US 20060240092 Patent (2009).
250. V. P. Torchilin, A. N. Lukyanov, Z. Gao, and B. Papahadjopoulos- Sternberg, Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs. Proc. Natl. Acad. Sci. USA 100, 6039 (2003).
251. K. Kataoka, T. Matsumotob, M. Yokoyamac, T. Okanoc, Y. Sakuraic, S. Fukushimad, K. Okamotod, and G. S. Kwone, Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: Their pharmaceutical characteristics and biological significance. J. Con. Rel. 64, 143 (2000).
252. N. Nishiyama, S. Okazaki, H. Cabral, M. Miyamoto, Y. Kato, Y. Sugiyama, K. Nishio, Y. Matsumura, and K. Kataoka, Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res. 63, 8977 (2003).
253. A. D'Emanuele and D. Attwood, Dendrimer-drug interactions. Adv. Drug Deliv. Rev. 57, 2147 (2005).
254. J. F. G. A. Jansen, E. M. M. De Brabander-van den Berg, and E. W. Meijer, Encapsulation of guest molecules into a dendritic box. Science 266, 1226 (1994).
255. V. S. Talanov, C. A. Regino, H. L. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging. Nano Lett. 6, 1459 (2006).
256. V. J. Venditto, C. A. Regino, and M. W. Brechbiel, PAMAM dendrimer based macromolecules as improved contrast agents. Mol. Pharm. 2, 302 (2005).
257. C. Yang, M. Neshatian, M. van Prooijen, and D. B. Chithrani, Cancer nanotechnology: Enhanced therapeutic response using peptide-modified gold nanoparticles. J. Nanosci. Nanotechnol. 14, 4813 (2014).
258. Y. Umeda, C. Kojima, A. Harada, H. Horinaka, and K. Kono, PEG-attached PAMAM dendrimers encapsulating gold nanoparticles: Growing gold nanoparticles in the dendrimers for improvement of their photothermal properties. Bioconjug. Chem. 18, 1559 (2010).