Predictors of lymph node metastasis in T1 colorectal carcinoma: An immunophenotypic analysis of 265 patients

Diseases of the Colon and Rectum

Volumn 57, Issue 8, 2014, Pages 905-915

  Nishida, Tsukasa ^a   Egashira, Yutaro ^a   Akutagawa, Hiroshi ^a   Fujii, Mototsugu ^a   Uchiyama, Kazuhisa ^a   Shibayama, Yuro ^a   Hirose, Yoshinobu ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

CD10 expression; Lymph node metastasis; MUC2 expression; MUC5AC expression; T1 colorectal cancer

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; MUCIN 2; MUCIN 5AC;

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CANCER SURGERY; CLINICAL FEATURE; COLORECTAL CARCINOMA; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; PROTEIN EXPRESSION; RADICAL RESECTION; RETROSPECTIVE STUDY; TUMOR GROWTH; TUMOR INVASION; TUMOR VOLUME; UNIVERSITY HOSPITAL;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; ENDOSCOPY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MUCIN 5AC; MUCIN-2; NEOPLASM GRADING; NEPRILYSIN; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84904860027     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0000000000000168     Document Type: Article

References (24)

1. Cooper HS, Deppisch LM, Gourley WK, et al. Endoscopically removed malignant colorectal polyps: clinicopathologic correlations. Gastroenterology. 1995;108: 1657-1665.
2. Ueno H, Mochizuki H, Hashiguchi Y, et al. Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology. 2004;127: 385-394. (Pubitemid 39091886)
3. Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer. 2004;4: 45-60. (Pubitemid 38082153)
4. Velcich A, Yang W, Heyer J, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002;295: 1726-1729. (Pubitemid 34202910)
5. Hanski C, Riede E, Gratchev A, et al. MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation. Lab Invest. 1997;77: 685-695. (Pubitemid 28018790)
6. Kocer B, Soran A, Erdogan S, et al. Expression of MUC5AC in colorectal carcinoma and relationship with prognosis. Pathol Int. 2002;52: 470-477. (Pubitemid 34989305)
7. Shipp MA, Look AT. Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood. 1993;82: 1052-1070. (Pubitemid 23253976)
8. Yao T, Takata M, Tustsumi S, et al. Phenotypic expression of gastrointestinal differentiation markers in colorectal adenocarcinomas with liver metastasis. Pathology. 2002;34: 556-560. (Pubitemid 36026731)
9. Kuniyasu H, Luo Y, Fujii K, et al. CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver. Gut. 2010;59: 348-356.
10. Fujimoto Y, Nakanishi Y, Sekine S, et al. CD10 expression in colorectal carcinoma correlates with liver metastasis. Dis Colon Rectum. 2005;48: 1883-1889. (Pubitemid 41437672)
11. Luo Y, Fujii K, Ohmori H, et al. Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer. Pathobiology. 2009;76: 267-273.
12. Shimoda T, Ikegami M, Fujisaki J, et al. Early colorectal carcinoma with special reference to its development de novo. Cancer. 1989;64: 1138-1146. (Pubitemid 19208871)
13. Hamilton SR, Aaltonen LA. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon, France: IARC Press; 2000: 103-119.
14. Haggitt RC, Glotzbach RE, Soffer EE, Wruble LD. Prognostic factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy. Gastroenterology. 1985;89: 328-336. (Pubitemid 15028589)
15. Watanabe T, Itabashi M, Shimada Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol. 2012;17: 1-29.
16. Iwase T, Kushima R, Mukaisho K, et al. Overexpression of CD10 and reduced MUC2 expression correlate with the development and progression of colorectal neoplasms. Pathol Res Pract. 2005;201: 83-91. (Pubitemid 40443821)
17. Breivik J, Lothe RA, Meling GI, et al. Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors. Int J Cancer. 1997;74: 664-669. (Pubitemid 28037512)
18. Hamelin R, Laurent-Puig P, Olschwang S, et al. Association of p53 mutations with short survival in colorectal cancer. Gastroenterology. 1994;106: 42-48. (Pubitemid 24011863)
19. Lanza G Jr, Maestri I, Dubini A, et al. p53 expression in colorectal cancer: relation to tumor type, DNA ploidy pattern and short-term survival. Am J Clin Pathol. 1996;105: 604-612. (Pubitemid 26152079)
20. Biemer-Hüttmann AE, Walsh MD, McGuckin MA, et al. Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clin Cancer Res. 2000;6: 1909-1916. (Pubitemid 30305089)
21. Lothe RA, Peltomäki P, Meling GI, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res. 1993;53: 5849-5852. (Pubitemid 24006146)
22. Slattery ML, Curtin K, Wolff RK, et al. A comparison of colon and rectal somatic DNA alterations. Dis Colon Rectum. 2009;52: 1304-1311.
23. Zlobec I, Lugli A. Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget. 2010;1: 651-661.
24. Blank M, Klussmann E, Krüger-Krasagakes S, et al. Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types. Int J Cancer. 1994;59: 301-306. (Pubitemid 24331817)