Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea

American Journal of Hypertension

Volumn 27, Issue 10, 2014, Pages 1293-1300

  Linz, Dominik ^a   Mahfoud, Felix ^a   Linz, Benedikt ^a   Hohl, Mathias ^a   Schirmer, Stephan H ^a   Wirth, Klaus J ^b   Böhm, Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Blood pressure; Blood pressure rise; Hypertension; Renal denervation; Renal perfusion; Sleep apnea

Indexed keywords

ALDOSTERONE; CHLORALOSE; CREATININE; IRBESARTAN; URETHAN; ANTIHYPERTENSIVE AGENT; BIPHENYL DERIVATIVE; RENIN; TETRAZOLE DERIVATIVE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY BLOOD FLOW; ARTICLE; BLOOD GAS; BLOOD PRESSURE; BREATHING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CREATININE URINE LEVEL; FEMORAL ARTERY FLOW; GLOMERULUS FILTRATION RATE; HEART RATE; HUMORAL IMMUNITY; KIDNEY ARTERY; KIDNEY DENERVATION; KIDNEY PERFUSION; NEUROHUMORAL RESPONSE; NONHUMAN; OSCILLATION; PLASMA RENIN ACTIVITY; PORCINE MODEL; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RENAL ARTERY FLOW; RENAL HYPOPERFUSION; RENAL SYMPATHETIC DENERVATION; SLEEP DISORDERED BREATHING; SYMPATHETIC INNERVATION; SYSTOLIC BLOOD PRESSURE; TRACHEA OBSTRUCTION; ANIMAL; BLOOD; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HYPERTENSION; INNERVATION; KIDNEY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEINURIA; SYMPATHECTOMY; URINE; VASCULARIZATION;

ALDOSTERONE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIPHENYL COMPOUNDS; BLOOD PRESSURE; CREATININE; DISEASE MODELS, ANIMAL; HYPERTENSION; KIDNEY; PROTEINURIA; RENAL ARTERY; RENIN; SLEEP APNEA, OBSTRUCTIVE; SYMPATHECTOMY; TETRAZOLES;

EID: 84904763257     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpu036     Document Type: Article

References (40)

1. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002; 165:1217-1239.
2. Resnick HE, Redline S, Shahar E, Gilpin A, Newman A, Walter R, Ewy GA, Howard BV, Punjabi NM; Sleep Heart Health Study. Diabetes and sleep disturbances: findings from the Sleep Heart Health Study. Diabetes Care 2003; 26:702-709.
3. Baguet JP, Barone-Rochette G, Pepin JL. Hypertension and obstructive sleep apnoea syndrome: current perspectives. J Hum Hypertens 2009; 23:431-443.
4. Aronsohn RS, Whitmore H, Van Cauter E, Tasali E. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am J Respir Crit Care Med 2010; 181:507-513.
5. Kinebuchi S, Kazama JJ, Satoh M, Sakai K, Nakayama H, Yoshizawa H, Narita I, Suzuki E, Gejyo F. Short-term use of continuous positive airway pressure ameliorates glomerular hyperfiltration in patients with obstructive sleep apnoea syndrome. Clin Sci (Lond) 2004; 107:317-322.
6. Daskalopoulou EG, Liavvas C, Nakas CT, Vlachogiannis EG, Bouros D, Dombros NV. Obstructive sleep apnoea syndrome promotes reversal albuminuria during sleep. Sleep Breath 2011; 15:589-597.
7. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000; 342:1378-1384.
8. Logan AG, Perlikowski SM, Mente A, Tisler A, Tkacova R, Niroumand M, Leung RS, Bradley TD. High prevalence of unrecognized sleep apnea in drug-resistant hypertension. J Hypertens 2001; 19:2271-2277.
9. Narkiewicz K, Somers VK. Sympathetic nerve activity in obstructive sleep apnea. Acta Physiol Scand 2003; 177:385-390.
10. Converse RL Jr, Jacobsen TN, Toto RD, Jost CM, Cosentino F, Fouad-Tarazi F, Victor RG. Sympathetic overactivity in patients with chronic renal failure. N Engl J Med 1992; 327:1912-1918.
11. Rump LC, Amann K, Orth S, Ritz E. Sympathetic overactivity in renal disease: a window to understand progression and cardiovascular complications of uraemia? Nephrol Dial Transplant 2000; 15:1735-1738.
12. Campese VM, Krol E. Neurogenic factors in renal hypertension. Curr Hypertens Rep 2002; 4:256-260.
13. Sobotka PA, Mahfoud F, Schlaich MP, Hoppe UC, Böhm M, Krum H. Sympatho-renal axis in chronic disease. Clin Res Cardiol 2011; 100:1049-1057.
14. Schlaich MP, Socratous F, Hennebry S, Eikelis N, Lambert EA, Straznicky N, Esler MD, Lambert GW. Sympathetic activation in chronic renal failure. J Am Soc Nephrol 2009; 20:933-939.
15. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 2009; 373:1275-1281.
16. Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 2009; 361:932-934.
17. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 2010; 376:1903-1909.
18. Witkowski A, Prejbisz A, Florczak E, Kądziela J, Śliwiński P, Bieleń P, Michałowska I, Kabat M, Warchoł E, Januszewicz M, Narkiewicz K, Somers VK, Sobotka PA, Januszewicz A. Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea. Hypertension 2011; 58:559-565.
19. Mahfoud F, Cremers B, Janker J, Link B, Vonend O, Ukena C, Linz D, Schmieder R, Rump LC, Kindermann I, Sobotka PA, Krum H, Scheller B, Schlaich M, Laufs U, Böhm M. Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension. Hypertension 2012; 60:419-424.
20. Linz D, Schotten U, Neuberger HR, Böhm M, Wirth K. Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation. Heart Rhythm 2011; 8:1436-1443.
21. Linz D, Mahfoud F, Schotten U, Ukena C, Neuberger HR, Wirth K, Böhm M. Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea. Hypertension 2012; 60:172-178.
22. Orban M, Bruce CJ, Pressman GS, Leinveber P, Romero-Corral A, Korinek J, Konecny T, Villarraga HR, Kara T, Caples SM, Somers VK. Dynamic changes of left ventricular performance and left atrial volume induced by the mueller maneuver in healthy young adults and implications for obstructive sleep apnea, atrial fibrillation, and heart failure. Am J Cardiol 2008; 102:1557-1561.
23. Peebles KC, Horsman H, Tzeng YC. The influence of tobacco smoking on the relationship between pressure and flow in the middle cerebral artery in humans. PLoS One 2013; 8:e72624.
24. Kohler M, Stradling JR. Mechanisms of vascular damage in obstructive sleep apnea. Nat Rev Cardiol 2010; 7:677-685.
25. Brinker JA, Weiss JL, Lappe DL, Rabson JL, Summer WR, Permutt S, Weisfeldt ML. Leftward septal displacement during right ventricular loading in man. Circulation 1980; 61:626-633.
26. Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc 2004; 79:1036-1046.
27. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev 1997; 77:75-197.
28. Moller DS, Lind P, Strunge B, Pedersen EB. Abnormal vasoactive hormones and 24-hour blood pressure in obstructive sleep apnea. Am J Hypertens 2003; 16:274-280.
29. Faulx MD, Storfer-Isser A, Kirchner HL, Jenny NS, Tracy RP, Redline S. Obstructive sleep apnea is associated with increased urinary albumin excretion. Sleep 2007; 30:923-929.
30. Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G. Urinary protein excretion rate is the best independent predictor of ESRF in nondiabetic proteinuric chronic nephropathies. "Gruppo Italiano di Studi Epidemiologici in Nefrologia" (GISEN). Kidney Int 1998; 53:1209-1216.
31. Grassi G, Quarti-Trevano F, Seravalle G, Arenare F, Volpe M, Furiani S, Dell'Oro R, Mancia G. Early sympathetic activation in the initial clinical stages of chronic renal failure. Hypertension 2011; 57: 846-851.
32. Rafiq K, Noma T, Fujisawa Y, Ishihara Y, Arai Y, Nabi AH, Suzuki F, Nagai Y, Nakano D, Hitomi H, Kitada K, Urushihara M, Kobori H, Kohno M, Nishiyama A. Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation. Circulation 2012; 125:1402-1413.
33. Hering D, Mahfoud F, Walton AS, Krum H, Lambert GW, Lambert EA, Sobotka PA, Böhm M, Cremers B, Esler MD, Schlaich MP. Renal denervation in moderate to severe CKD. J Am Soc Nephrol 2012; 23:1250-1257.
34. Abu-Amarah I, Ajikobi DO, Bachelard H, Cupples WA, Salevsky FC. Responses of mesenteric and renal blood flow dynamics to acute denervation in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 1998; 275:1543-1552.
35. Just A, Wittmann U, Ehmke H, Kirchheim HR. Autoregulation of renal blood flow in the conscious dog and the contribution of the tubuleglomerular feedback. J Physiol 1998; 506:275-290.
36. Osborn JL, Francisco LL, DiBona GF. Effect of renal nerve stimulation on renal blood flow autoregulation and antinatriuresis during reduction in renal perfusion pressure. Proc Soc Exp Biol Med 1981; 168:77-81.
37. DiBona G, Sawin LL. Effect of renal denervation on dynamic autoregulation of renal blood flow. Am J Physiol Renal Physiol 2004; 1209-1218.
38. Malpas SC, Evans RG. Do different levels and patterns of sympathetic activation all provoke renal vasoconstriction? J Auton Nerv Syst 1998; 69:72-82.
39. Malpas SC, Evans RG, Head GA, Lukoshkova EV. Contribution of renal nerves to renal blood flow variability during hemorrhage. Am J Physiol Regul Integr Comp Physiol 1998; 274:1283-1294.
40. Tsioufis C, Papademetriou V, Dimitriadis K, Tsiachris D, Thomopoulos C, Park E, Hata C, Papalois A, Stefanadis C. Catheter-based renal sympathetic denervation exerts acute and chronic effects on renal hemodynamics in swine. Int J Cardiol 2012; 168:987-992.