Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs

Current Pharmaceutical Design

Volumn 20, Issue 27, 2014, Pages 4346-4356

  Bottai, Daria ^a   Serafini, Agnese ^b   Cascioferro, Alessandro ^c   Brosch, Roland ^c   Manganelli, Riccardo ^b  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c INSTITUT PASTEUR   (France)

Author keywords

Drugs development; M. tuberculosis; Secretion; Tuberculosis; Virulence

Indexed keywords

ANTIMYCOBACTERIAL AGENT; BACTERIAL PROTEIN; TUBERCULOSTATIC AGENT;

BACTERIAL CLEARANCE; BACTERIAL SECRETION SYSTEM; BACTERIAL VIRULENCE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CELL MEMBRANE; HOST PATHOGEN INTERACTION; MULTIDRUG RESISTANCE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM LEPRAEMURIUM; MYCOBACTERIUM MARINUM; MYCOBACTERIUM MICROTI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM ULCERANS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SECRETORY PATHWAY; TYPE I SECRETION SYSTEM; TYPE II SECRETION SYSTEM; TYPE III SECRETION SYSTEM; TYPE IV SECRETION SYSTEM; TYPE V SECRETION SYSTEM; TYPE VII SECRETION SYSTEM; BINDING SITE; CELL WALL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PROCEDURES; SEQUENCE ALIGNMENT; VIRULENCE;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BACTERIAL SECRETION SYSTEMS; BASE SEQUENCE; BINDING SITES; CELL WALL; DRUG DISCOVERY; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; SEQUENCE ALIGNMENT; VIRULENCE;

EID: 84904757822     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612819666131118170717     Document Type: Review

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