Insertions in the OCL1 locus of Acinetobacter baumannii lead to shortened lipooligosaccharides

Research in Microbiology

Volumn 165, Issue 6, 2014, Pages 472-475

  Kenyon, Johanna J ^a   Holt, Kathryn E ^b   Pickard, Derek ^c   Dougan, Gordon ^c   Hall, Ruth M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

ISAba1; ISAba23; Lipid A; Lipooligosaccharide; OC locus; Outer core oligosaccharide

Indexed keywords

LIPOOLIGOSACCHARIDE; BACTERIAL DNA; LIPID-LINKED OLIGOSACCHARIDES; LIPOPOLYSACCHARIDE; TRANSPOSON;

ACINETOBACTER BAUMANNII; ARTICLE; BACTERIAL GENOME; BACTERIUM ISOLATE; GENE INSERTION; GENE INSERTION SEQUENCE; GENE LOCUS; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; OUTER CORE LOCUS 1; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CHEMISTRY; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; TRANSPOSON;

ACINETOBACTER BAUMANNII;

ACINETOBACTER BAUMANNII; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; GENETIC LOCI; LIPOPOLYSACCHARIDES; METABOLIC NETWORKS AND PATHWAYS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTAGENESIS, INSERTIONAL; SEQUENCE ANALYSIS, DNA;

EID: 84904742727     PISSN: 09232508     EISSN: 17697123     Source Type: Journal    
DOI: 10.1016/j.resmic.2014.05.034     Document Type: Article

References (17)

1. Preston A., Mandrell R.E., Gibson B.W., Apicella M.A. The lipooligosaccharides of pathogenic Gram-negative bacteria. Crit Rev Microbiol 1996, 22:139-180.
2. Kenyon J.J., Hall R.M. Variation in the complex carbohydrate biosynthesis loci of Acinetobacter baumannii genomes. PLoS One 2013, 8:e62160.
3. Reeves P.R., Wang L. Genomic organization of LPS-specific loci. Curr Top Microbiol Immunol 2002, 264:109-135.
4. Kenyon J.J., Marziaoli A.M., Hall R.M., De Castro C. Structure of the K2 capsule associated with the KL2 gene cluster of Acinetobacter baumannii. Glycobiology 2014, 24:554-563.
5. Lees-Miller R.G., Iwashkiw J.A., Scott N.E., Seper A., Vinogradov E., Schild S., et al. A common pathway for O-linked protein-glycosylation and synthesis of capsule in Acinetobacter baumannii. Mol Microbiol 2013, 89:816-830.
6. Vinogradov E., Duus J., Brade H., Holst O. The structure of the carbohydrate backbone of the lipopolysaccharide from Acinetobacter baumannii strain ATCC 19606. Eur J Biochem 2002, 269:422-430.
7. Fregolino E., Fugazza G., Galano E., Gargiulo V., Landini P., Lanzetta R., et al. Complete lipooligosaccharide structure of the clinical isolate Acinetobacter baumannii, strain SMAL. Eur J Org Chem 2010, 2010:1345-1352.
8. Diancourt L., Passet V., Nemec A., Dijkshoorn L., Brisse A. The population structure of Acinetobacter baumannii: expanding multiresistant clones from an ancestral susceptible genetic pool. PLoS One 2010, 5:e10034.
9. Nigro S.J., Post V., Hall R.M. Aminoglycoside resistance in multiply antibiotic-resistant Acinetobacter baumannii belonging to global clone 2 from Australian hospitals. J Antimicrob Chemother 2011, 66:1504-1509.
10. Hamidian M., Hall R.M. Tn6168, a transposon carrying an ISAba1-activated ampC gene and conferring cephalosporin resistance in Acinetobacter baumannii. J Antimicrob Chemother 2014, 69:77-80.
11. Hamidian M., Holt K.E., Pickard D., Dougan G., Hall R.M. A GC1 Acinetobacter baumannii isolate carrying AbaR3 and the aminoglycoside resistance transposon TnaphA6 in a conjugative plasmid. J Antimicrob Chemother 2014, 69:955-958.
12. Hamidian M., Hall R.M. ISAba1 targets a specific position upstream of the intrinsic ampC gene of Acinetobacter baumannii leading to cephalosporin resistance. J Antimicrob Chemother 2013, 68:2682-2683.
13. Fregolino E., Gargiulo V., Lanzetta R., Parrilli M., Holst O., De Castro C. Identification and structural determination of the capsular polysaccharides from two Acinetobacter baumannii clinical isolates, MG1 and SMAL. Carbohydr Res 2011, 346:973-977.
14. Kenyon J.J., Reeves P.R. The Wzy O-antigen polymerase of Yersinia pseudotuberculosis O:2a has a dependence on the Wzz chain-length determinant for efficient polymerization. FEMS Microbiol Lett 2013, 349:163-170.
15. Pantophlet R., Brade L., Brade H. Detection of lipid A by monoclonal antibodies in S-form lipopolysaccharide after acidic treatment of immobilized LPS on western blot. J Endotoxin Res 1997, 4:89-95.
16. Hanuszkiewicz A., Kaczynski Z., Lindner B., Goldmann T., Vollmer E., Debarry J., et al. Structural analysis of the capsular polysaccharide from Acinetobacter lwoffii F78. Eur J Org Chem 2008, 6183-6188.
17. De Castro C., Parrilli M., Holst O., Molinaro A. Microbe-associated molecular patterns in innate immunity: extraction and chemical analysis of Gram-negative bacterial lipopolysaccharides. Meth Enzymol 2010, 480:89-115.