Impaired executive function in contemplated and attempted suicide in late life

American Journal of Geriatric Psychiatry

Volumn 22, Issue 8, 2014, Pages 811-819

  Gujral, Swathi ^a   Dombrovski, Alexandre Y ^a   Butters, Meryl ^a   Clark, Luke ^c   Reynolds III, Charles F ^a,b   Szanto, Katalin ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c University of Cambridge   (United Kingdom)

Author keywords

Aged; Cognitive; Depression; Executive function; Suicide

Indexed keywords

ADULT; AGED; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA RATING SCALE; DRUG EXPOSURE; EDUCATIONAL STATUS; EXECUTIVE FUNCTION; EXPLORATORY RESEARCH; FEMALE; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MEMORY AND ATTENTION SUBSCALE; MENTAL HOSPITAL; RATING SCALE; SENSITIVITY ANALYSIS; SUBSTANCE ABUSE; SUICIDAL IDEATION; SUICIDE ATTEMPT; UNIVERSITY HOSPITAL;

EID: 84904738822     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1016/j.jagp.2013.01.025     Document Type: Article

References (38)

1. World Health Organization: Suicide prevention. Geneva, Switzerland, WHO, 2005
2. Goldsmith SK, Pellmar TCKA, Bunney WE (eds.): Reducing Suicide: A National Imperative. Washington, DC, National Academies Press, 2002
3. Abas MA, Sahakian BJ, Levy R: Neuropsychological deficits and CT scan changes in elderly depressives. Psychol Med 1990; 20: 507-520
4. Sheline YI, Barch DM, Garcia K, et al: Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed. Biol Psychiatry 2006; 60:58-65
5. Alexopoulos G, Kiosses DN, Klimstra S, et al: Clinical presentation of the "depression-executive dysfunction syndrome" of latelife. Am J Geriatr Psychiatry 2002; 10:98-102
6. Butters MA, Whyte EM, Nebes RD, et al: The nature and determinants of neuropsychological functioning in late-life depression. Arch Gen Psychiatry 2004; 61:587-595
7. Jollant F, Lawrence NL, Olie E, et al: The suicidal mind and brain: a review of neuropsychological and neuroimaging studies. World J Biol Psychiatry 2011; 12:319-339
8. Conwell Y, Van Orden K, Caine ED: Suicide in older adults. Psychiatr Clin N Am 2011; 34:451-468
9. Bartfai A, Winborg IM, Nordstrom P, et al: Suicidal behavior and cognitive flexibility: design and verbal fluency after attempted suicide. Suicide Life Threat Behav 1990; 20: 254-266
10. Keilp JG, Sackeim HA, Brodsky BS, et al: Neuropsychological dysfunction in depressed suicide attempters. Am J Psychiatry 2001; 158:735-741
11. Keilp JG, Gorlyn M, Oquendo MA, et al: Attention deficit in depressed suicide attempters. Psychiatry Res 2008; 159:7-17
12. Jollant F, Bellivier F, Leboyer M, et al: Impaired decision making in suicide attempters. Am J Psychiatry 2005; 162:304-310
13. Jollant F, Guillaume S, Jaussent I, et al: Characterization of decision-making impairment in suicide attempters and the influence of attention to wins on suicidal intent and repetition. Biol Psychiatry 2008; 63:292S
14. Westheide J, Quednow BB, Kuhn KU, et al: Executive performance of depressed suicide attempters: the role of suicidal ideation. Eur Arch Psychiatry Clin Neurosci 2008; 258: 414-421
15. Cha CB, Najmi S, Park JM, et al: Attentional bias toward suiciderelated stimuli predicts suicidal behavior. J Abnorm Psychol 2010; 119:616-622
16. Marzuk PM, Hartwell N, Leon AC, et al: Executive functioning in depressed patients with suicidal ideation. Acta Psychiatr Scand 2005; 112:294-301
17. King DA, Conwell Y, Cox C, et al: A neuropsychological comparison of depressed suicide attempters and nonattempters. J Neuropsychiatry Clin Neurosc 2000; 12:64-70
18. Dombrovski AY, Butters MA, Reynolds CF, 3rd, et al: Cognitive performance in suicidal depressed elderly: preliminary report. Am J Geriatr Psychiatry 2008; 16:109-115
19. Dombrovski AY, Clark L, Siegle GJ, et al: Reward/punishment reversal learning in older suicide attempters. Am J Psychiatry 2010; 167:699-707
20. McGirr A, Dombrovski AY, Butters MA, et al: Deterministic learning and attempted suicide among older depressed individuals: cognitive assessment using the Wisconsin Card Sorting Task. J Psychiatr Res 2011; 46:226-232
21. Beck AT, Beck R, Kovacs M: Classification of suicidal behaviors: I. Quantifying intent and medical lethality. Am J Psychiatry 1975; 132:285-287
22. Beck AT, Shuyler D, Herman I: Development of suicidal intent scales, in The Prediction of Suicide. Edited by Beck AT, Resnik HLP, Lettieri DJ, Bowie MD. Philadelphia, Charles Press, 1974, pp 45-56
23. Beck AT, Kovacs M, Weissman A: Assessment of suicidal intention: the scale for suicide ideation. J Consult Clin Psychol 1979; 47:343-352
24. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23:56-62
25. Miller MD, Paradis CF, Houck PR, et al: Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res 1992; 41:237-248
26. Beck AT, Weissman A, Lester D, et al: The measurement of pessimism: the hopelessness scale. J Consult Clin Psychol 1974; 42:861-865
27. Sackeim HA: The definition and meaning of treatment-resistant depression. J Clin Psychiatry 2001; 62(suppl 16):10-17
28. Royall DR, Mahurin RK, Gray KF: Bedside assessment of executive cognitive impairment: the executive interview. J Am Geriatr Soc 1992; 40:1221-1226
29. Mattis S: Dementia Rating Scale (DRS): Professional Manual. Odessa, FL, Psychological Assessment Resources Inc., 1988
30. Wechsler D: The Wechsler Test of Adult Reading: WTAR. San Antonio, TX, Psychological Corporation, 2001
31. Baumeister RF, DeWall CN, Ciarocco NJ, et al: Social exclusion impairs self-regulation. J Pers Soc Psychol 2005; 88:589-604
32. Miller EK, Cohen JD: An integrative theory of prefrontal cortex function. Annu Rev Neurosci 2001; 24:167-202
33. Ridderinkhof KR, van den Wildenberg WP, Segalowitz SJ, et al: Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning. Brain Cogn 2004; 56:129-140
34. Botvinick MM, Braver TS, Barch DM, et al: Conflict monitoring and cognitive control. Psychol Rev 2001; 108:624-652
35. Raust A, Slama F, Mathieu F, et al: Prefrontal cortex dysfunction in patients with suicidal behavior. Psychol Med 2007; 37: 411-419
36. Haw C, Harwood D, Hawton K: Dementia and suicidal behavior: a review of the literature. Int Psychogeriatr 2009; 21: 440-453
37. Seyfried LS, Kales HC, Ignacio RV, et al: Predictors of suicide in patients with dementia. Alzheimers Dement 2011; 7: 567-573
38. Reynolds CF 3rd, Butters MA, Lopez O, et al: Maintenance treatment of depression in old age: a randomized, double blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy. Arch Gen Psychiatry 2011; 68:51-60