Multi-step microfluidic system for blood plasma separation: Architecture and separation efficiency

Microfluidics and Nanofluidics

Volumn 17, Issue 1, 2014, Pages 167-180

  Marchalot, Julien ^a   Fouillet, Yves ^a   Achard, Jean Luc ^b  

^a CEA LETI   (France)

^b LEGI   (France)

Author keywords

Architectural fluidic connection; Blood plasma separation; Cell free layer; Continuous; Passive; Plasma yield

Indexed keywords

BIOASSAY; BIOCHIPS; BLOOD; FLUIDIC DEVICES; PLASMAS;

ARCHITECTURAL FLUIDIC CONNECTION; BLOOD-PLASMA SEPARATION; CELL-FREE; CONTINUOUS; PASSIVE; PLASMA YIELDS;

SEPARATION;

EID: 84904724859     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-013-1296-4     Document Type: Article

References (43)

1. Amasia M, Madou M (2010) Large-volume centrifugal microfluidic device for blood plasma separation. Bioanalysis 2:1701-1710. doi: 10.4155/bio.10.140
2. Arifin DR, Yeo LY, Friend JR (2007) Microfluidic blood plasma separation via bulk electrohydrodynamic flows. Biomicrofluidics 1:14103. doi: 10.1063/1.2409629
3. Armstrong JK, Wenby RB, Meiselman HJ, Fisher TC (2004) The hydrodynamic radii of macromolecules and their effect on red blood cell aggregation. Biophys J 87:4259-4270. doi: 10.1529/biophysj.104.047746
4. Barthes-Biesel D, Sgaier H (1985) Role of membrane viscosity in the orientation and deformation of a spherical capsule suspended in shear flow. J Fluid Mech 160:119-135
5. Berger SA, Talbot L, Yao LS (1983) Flow in curved pipes. Annu Rev Fluid Mech 15:461-512. doi: 10.1146/annurev.fl.15.010183.002333
6. Browne AW, Ramasamy L, Cripe TP, Ahn CH (2011) A lab-on-a-chip for rapid blood separation and quantification of hematocrit and serum analytes. Lab Chip 11:2440-2446. doi: 10.1039/c1lc20144a
7. Cheng X, Gupta A, Chen C et al (2009) Enhancing the performance of a point-of-care CD4 + T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics. Lab Chip 9:1357-1364. doi: 10.1039/b818813k
8. Davis JA, Inglis DW, Morton KJ et al (2006) Deterministic hydrodynamics: taking blood apart. Proc Natl Acad Sci USA 103:14779-14784. doi: 10.1073/pnas.0605967103
9. Di Carlo D, Irimia D, Tompkins RG, Toner M (2007) Continuous inertial focusing, ordering, and separation of particles in microchannels. Proc Natl Acad Sci USA 104:18892-18897. doi: 10.1073/pnas.0704958104
10. Dimov IK, Basabe-Desmonts L, Garcia-Cordero JL et al (2011) Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS). Lab Chip 11:845-850. doi: 10.1039/c0lc00403k
11. Fahraeus R, Lindqvist T (1931) The viscosity of the blood in narrow capillary tubes. Am J Physiol 96(3):562-568
12. Faivre M, Abkarian M, Bickraj K, Stone HA (2006) Geometrical focusing of cells in a microfluidic device: an approach to separate blood plasma. Biorheology 43:147-159
13. Feng J, Hu HH, Joseph DD (1994a) Direct simulation of initial value problems for the motion of solid bodies in a Newtonian fluid. Part 2. Couette and Poiseuille flows. J Fluid Mech 277:271-301
14. Feng J, Hu HH, Joseph DD (1994b) Direct simulation of initial value problems for the motion of solid bodies in a Newtonian fluid Part 1. Sedimentation. J Fluid Mech 261:95-134
15. Furlani EP (2007) Magnetophoretic separation of blood cells at the microscale. J Phys D Appl Phys 40:1313-1319
16. Gavze E, Shapiro M (1998) Motion of inertial spheroidal particles in a shear flow near a solid wall with special application to aerosol transport in microgravity. J Fluid Mech 371:59-79
17. Gleghorn JP, Pratt ED, Denning D et al (2010) Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody. Lab Chip 10:27-29. doi: 10.1039/b917959c
18. Homsy A, van der Wal PD, Doll W et al (2012) Development and validation of a low cost blood filtration element separating plasma from undiluted whole blood. Biomicrofluidics 6:12804-128049. doi: 10.1063/1.3672188
19. Iliescu C, Xu G, Barbarini E et al (2008) Microfluidic device for continuous magnetophoretic separation of white blood cells. Microsyst Technol 15:1157-1162. doi: 10.1007/s00542-008-0718-9
20. Keller SR, Skalak R (1982) Motion of a tank-treading ellipsoidal particle in a shear flow. J Fluid Mech 120:27-47
21. Kersaudy-Kerhoas M, Dhariwal R, Desmulliez MPY, Jouvet L (2009) Hydrodynamic blood plasma separation in microfluidic channels. Microfluid Nanofluid 8:105-114. doi: 10.1007/s10404-009-0450-5
22. Lenshof A, Ahmad-Tajudin A, Järås K et al (2009) Acoustic whole blood plasmapheresis chip for prostate specific antigen microarray diagnostics. Anal Chem 81:6030-6037. doi: 10.1021/ac9013572
23. Maltezos G, Lee J, Rajagopal A et al (2011) Microfluidic blood filtration device. Biomed Microdevices 13:143-146. doi: 10.1007/s10544-010-9479-1
24. Markle DR, Evans EA, Hochmuth RM (1983) Force relaxation and permanent deformation of erythrocyte membrane. Biophys J 42:91-98. doi: 10.1016/S0006-3495(83)84372-0
25. Matsuda M, Yamada M, Seki M (2011) Blood cell classification utilizing hydrodynamic filtration. Electron Commun Jpn 94:1-6. doi: 10.1002/ecj.10281
26. Mills JP, Qie L, Dao M et al (2004) Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers. Mech Chem Biosyst 1:169-180
27. Nakashima Y, Hata S, Yasuda T (2010) Blood plasma separation and extraction from a minute amount of blood using dielectrophoretic and capillary forces. Sens Actuators B Chem 145:561-569. doi: 10.1016/j.snb.2009.11.070
28. Olla P (1999) Simplified model for red cell dynamics in small blood vessels. Phys Rev Lett 82:453-456. doi: 10.1103/PhysRevLett.82.453
29. Ookawara S, Street D, Ogawa K (2006) Numerical study on development of particle concentration profiles in a curved microchannel. Chem Eng Sci 61:3714-3724. doi: 10.1016/j.ces.2006.01.016
30. Qi D, Luo L, Aravamuthan R, Strieder W (2002) Lateral migration and orientation of elliptical particles in Poiseuille flows. J Stat Phys 107:101-120. doi: 10.1023/A:1014502402884
31. Rubinow SI, Keller JB (1961) The transverse force on a spinning sphere moving in a viscous fluid. J Fluid Mech 11:447-459
32. Russom A, Gupta AK, Nagrath S et al (2009) Differential inertial focusing of particles in curved low-aspect-ratio microchannels. New J Phys 11:75025. doi: 10.1088/1367-2630/11/7/075025
33. Saffman PG (1965) The lift on a small sphere in a slow shear flow. J Fluid Mech 22:385-400
34. Segré G, Silberberg A (1962) Behaviour of macroscopic rigid spheres in Poiseuille flow Part 2. Experimental results and interpretation. J Fluid Mech 14:136-157
35. Sethu P, Moldawer LL, Mindrinos MN et al (2006) Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Anal Chem 78:5453-5461. doi: 10.1021/ac060140c
36. Sollier E, Rostaing H, Pouteau P et al (2009) Passive microfluidic devices for plasma extraction from whole human blood. Sens Actuators B Chem 141:617-624. doi: 10.1016/j.snb.2009.05.023
37. Sollier E, Cubizolles M, Fouillet Y, Achard J-L (2010) Fast and continuous plasma extraction from whole human blood based on expanding cell-free layer devices. Biomed Microdevices 12:485-497. doi: 10.1007/s10544-010-9405-6
38. Songjaroen T, Dungchai W, Chailapakul O et al (2012) Blood separation on microfluidic paper-based analytical devices. Lab Chip 12:3392-3398. doi: 10.1039/c2lc21299d
39. Toner M, Irimia D (2005) Blood-on-a-chip. Annu Rev Biomed Eng 7:77-103. doi: 10.1146/annurev.bioeng.7.011205.135108
40. Tran-Son-Tay R, Sutera SP, Rao PR (1984) Determination of red blood cell membrane viscosity from rheoscopic observations of tank-treading motion. Biophys J 46:65-72. doi: 10.1016/S0006-3495(84)83999-5
41. Tripathi S, Prabhakar A, Kumar N et al (2013) Blood plasma separation in elevated dimension T-shaped microchannel. Biomed Microdevices. doi: 10.1007/s10544-013-9738-z
42. Whittaker SR, Winton FR (1933) The apparent viscosity of blood flowing in the isolated hindlimb of the dog, and its variation with corpuscular concentration. J physiol 78:339-369
43. Xia Y, Whitesides GM (1998) Soft lithography. Annu Rev Mater Sci 28:153-184. doi: 10.1146/annurev.matsci.28.1.153