Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity

Toxicology

Volumn 324, Issue , 2014, Pages 18-26

  Van Den Hof, Wim F P M ^a,d   Van Summeren, Anke ^a,d   Lommen, Arjen ^b,d   Coonen, Maarten L J ^a,d   Brauers, Karen ^a   van Herwijnen, Marcel ^a   Wodzig, Will K W H ^c,d   Kleinjans, Jos C S ^a,d  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Netherlands Toxicogenomics Centre   (Netherlands)

Author keywords

Cholestasis; Cyclosporin A; Hepatotoxicity; Integrated analysis; Primary mouse hepatocytes

Indexed keywords

CHOLESTEROL; CYCLOSPORIN A; DRUG METABOLITE; GLUCOSE; LIPID; MESSENGER RNA; MICRORNA 182; ADIPOPHILIN; ARFAPTIN 1 PROTEIN; CARBOXYLESTERASE; GLUCOSE REGULATED PROTEIN 78; HYDROXYACYLGLUTATHIONE HYDROLASE; MICRORNA; MICRORNA 182 5P; MICRORNA 183; MICRORNA 20A; MICRORNA 212; MICRORNA 221; MICRORNA 3096B; MICRORNA 767; ORNITHINE CARBAMOYLTRANSFERASE; PERILIPIN 2; PROLINE RICH PROTEIN 15; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE A3; PROTEIN DISULFIDE ISOMERASE A4; SERUM ALBUMIN; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; LIVER CELL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SECRETION; TRANSCRIPTOMICS; ADULT; AMINO ACID METABOLISM; APOPTOSIS; BILE ACID METABOLISM; CELL SURFACE; CHOLESTASIS; COMPLEMENT SYSTEM; DRUG METABOLISM; GENE EXPRESSION PROFILING; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; LIPID HOMEOSTASIS; LIPID METABOLISM; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEOMICS; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALIA;

CHOLESTASIS; CYCLOSPORIN A; HEPATOTOXICITY; INTEGRATED ANALYSIS; PRIMARY MOUSE HEPATOCYTES;

ANIMALS; CELLS, CULTURED; CYCLOSPORINE; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKERS; GENOMICS; HEPATOCYTES; IMMUNOSUPPRESSIVE AGENTS; LIVER; MALE; METABOLOMICS; MICE; MICE, INBRED C57BL; MICRORNAS; PRIMARY CELL CULTURE; PROTEIN INTERACTION MAPPING; PROTEIN INTERACTION MAPS; PROTEOMICS; RISK ASSESSMENT; RNA, MESSENGER; SYSTEMS BIOLOGY;

EID: 84904723697     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.06.003     Document Type: Article

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