The TLR9 ligand, CpG-ODN, induces protection against cerebral ischemia/reperfusion injury via activation of PI3K/Akt signaling.

Journal of the American Heart Association

Volumn 3, Issue 2, 2014, Pages

  Lu, Chen ^a   Ha, Tuanzhu ^b   Wang, Xiaohui ^b   Liu, L ^b   Zhang, Xia ^b   Kimbrough, Erinmarie Olson ^b   Sha, Zhanxin ^b   Guan, Meijian ^b   Schweitzer, John ^b   Kalbfleisch, John ^b   Williams, David ^b   Li, Chuanfu ^b  

^a East Tennessee State University   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; LIGAND; NEUROPROTECTIVE AGENT; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TLR9 PROTEIN, MOUSE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9;

ANIMAL; APOPTOSIS; ARTICLE; BRAIN; BRAIN INFARCTION; C57BL MOUSE; CELL CULTURE; CEREBRAL ISCHEMIA/REPERFUSION INJURY; CPG-ODN; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYMOLOGY; MALE; METABOLISM; MICROGLIA; MOUSE; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TIME;

APOPTOSIS; CEREBRAL ISCHEMIA/REPERFUSION INJURY; CPG-ODN; TOLL-LIKE RECEPTORS;

ANIMALS; APOPTOSIS; BRAIN; CELLS, CULTURED; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 9;

EID: 84904709229     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000629     Document Type: Article

References (0)