Effect of ischemic postconditioning on infarct size in patients with ST-elevation myocardial infarction treated by primary PCI results of the POSTEMI (Postconditioning in ST-elevation myocardial infarction) randomized trial

Journal of the American Heart Association

Volumn 3, Issue 2, 2014, Pages

  Limalanathan, Shanmuganathan ^a,b   Andersen, Geir Ø ^a,b   Kløw, Nils Einar ^b   Abdelnoor, Michael ^b   Hoffmann, Pavel ^b   Eritsland, Jan ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Acute myocardial infarction; Infarct size; Percutaneous coronary intervention; Postconditioning; Reperfusion injury

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; HEPARIN; BIOLOGICAL MARKER; TROPONIN T;

ADULT; ARTERY REOCCLUSION; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CLINICAL TRIAL; CONTROL GROUP; CONTROLLED STUDY; CORONARY STENT; FEMALE; FOLLOW UP; HEART EJECTION FRACTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE NECROSIS; HUMAN; ISCHEMIC POSTCONDITIONING; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION; RISK FACTOR; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; SYMPTOM; ACUTE HEART INFARCTION; AGED; BALLOON OCCLUSION; BLOOD; CONTROLLED CLINICAL TRIAL; CORONARY ARTERY BLOOD FLOW; EQUIPMENT; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART STROKE VOLUME; INFARCT SIZE; METABOLISM; METHODOLOGY; MIDDLE AGED; MULTIVARIATE ANALYSIS; NECROSIS; NORWAY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; POSTCONDITIONING; PROSPECTIVE STUDY; REPERFUSION INJURY; STATISTICAL MODEL; STENT; TIME; TREATMENT OUTCOME;

ACUTE MYOCARDIAL INFARCTION; INFARCT SIZE; PERCUTANEOUS CORONARY INTERVENTION; POSTCONDITIONING; REPERFUSION INJURY;

AGED; BALLOON OCCLUSION; BIOLOGICAL MARKERS; CORONARY CIRCULATION; FEMALE; HUMANS; ISCHEMIC POSTCONDITIONING; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; MYOCARDIUM; NECROSIS; NORWAY; PERCUTANEOUS CORONARY INTERVENTION; PROSPECTIVE STUDIES; RISK FACTORS; STENTS; STROKE VOLUME; TIME FACTORS; TREATMENT OUTCOME; TROPONIN T; VENTRICULAR FUNCTION, LEFT;

EID: 84904707955     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000679     Document Type: Article

References (31)

1. Steg PG, James SK, Atar D, Badano LP, Blomstrom-Lundqvist C, Borger MA, Di Mario C, Dickstein K, Ducrocq G, Fernandez-Aviles F, Gershlick AH, Giannuzzi P, Halvorsen S, Huber K, Juni P, Kastrati A, Knuuti J, Lenzen MJ, Mahaffey KW, Valgimigli M, van't HOF A, Widimsky P, Zahger D. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation. Eur Heart J. 2012;33:2569-2619.
2. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357:1121-1135.
3. Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, Macia C, Raczka F, Sportouch C, Gahide G, Finet G, André-Fouët X, Revel D, Kirkorian G, Monassier J-P, Derumeaux G, Ovize M. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med. 2008;359:473-481.
4. Lønborg J, Vejlstrup N, Kelbæk H, Bøtker HE, Kim WY, Mathiasen AB, Jørgensen E, Helqvist S, Saunamäki K, Clemmensen P, Holmvang L, Thuesen L, Krusell LR, Jensen JS, Køber L, Treiman M, Holst JJ, Engstrøm T. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur Heart J. 2012;33:1491-1499.
5. Zhao Z-Q, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003;285:H579-H588.
6. Staat P, Rifoul G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit JF, Bonnefoy E, Finet G, André-Fouët X, Ovize M. Postconditioning the human heart. Circulation. 2005;112:2143-2148.
7. Ma XJ, Zhang XH, Li CM, Luo M. Effect of postconditioning on coronary blood flow velocity and endothelial function in patients with acute myocardial infarction. Scand Cardiovasc J. 2006;40:327-333.
8. Yang XC, Liu Y, Wang LF, Cui L, Wang T, Ge YG, Wang HS, Li WM, Xu L, Ni ZH, Liu SH, Zhang L, Jia HM, Vinten-Johansen J, Zhao ZQ. Reduction in myocardial infarct size by postconditioning in patients after percutaneous coronary intervention. J Invasive Cardiol. 2007;19:424-430.
9. Thibault H, Piot C, Staat P, Bontemps L, Sportouch C, Rioufol G, Cung TT, Bonnefoy E, Angoulvant D, Aupetit JF, Finet G, André-Fouët X, Macia JC, Raczka F, Rossi R, Itti R, Kirkorian G, Derumeaux G, Ovize M. Long-term benefit of postconditioning. Circulation. 2008;117:1037-1044.
10. Laskey WK, Yoon S, Calzada N, Ricciardi MJ. Concordant improvements in coronary flow reserve and ST-segment resolution during percutaneous coronary intervention for acute myocardial infarction: a benefit of postconditioning. Catheter Cardiovasc Interv. 2008;72:212-220.
11. Limalanathan S, Andersen GØ, Hoffmann P, Kløw NE, Abdelnoor M, Eritsland J. Rationale and design of the POSTEMI (POstconditioning in ST-Elevation Myocardial Infarction) Study. Cardiology. 2010;116:103-109.
12. Rentrop KP, Cohen M, Blanke H, Philips RA. Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol. 1985;5:587-592.
13. TIMI Study Group. Available at: http//www.timi.org/education/definitions. Accessed March 7, 2014.
14. Andersen GØ, Knudsen EC, Aukrust P, Yndestad A, Oie E, Müller C, Seljeflot I, Ueland T. Elevated serum osteoprotegerin levels, measured early after acute ST-elevation myocardial infarction predict final infarct size. Heart. 2011;97:460-465.
15. Vickers AJ, Altman DG. Analysing controlled trials with baseline and follow up measurements. BMJ. 2001;323:1123-1124.
16. Pocock SJ, Assmann SE, Enos LE, Kasten LE. Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems. Stat Med. 2002;21:2917-2930.
17. Bell ML, Kenward MG, Fairclough DL, Horton NJ. Differential dropout and bias in randomised controlled trials: when it matters and when it may not. BMJ. 2013;346:e8668.
18. Lønborg J, Kelbæk H, Vejlstrup N, Jørgensen E, Helqvist S, Saunamäki K, Clemmensen P, Holmvang L, Treiman M, Jensen JS, Engstrøm T. Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ Cardiovasc Interv. 2010;3:34-41.
19. Xue F, Yang X, Zhang B, Zhao C, Song J, Jiang T, Jiang W. Postconditioning in human heart in percutaneous coronary intervention. Clin Cardiol. 2010; 33:439-444.
20. Sörensson P, Saleh N, Bouvier F, Böhm F, Settergren M, Caidahl K, Tornvall P, Arheden H, Rydén L, Pernow J. Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction. Heart. 2010;96:1710-1715.
21. Garcia S, Henry TD, Wang YL, Chavez IJ, Pedersen WR, Lesser JR, Shroff GR, Moore L, Traverse JH. Long-term follow-up of patients undergoing postconditioning during ST-elevation myocardial infarction. J Cardiovasc Trans Res. 2011;4:92-98.
22. Tarantini G, Favaretto E, Marra MP, Frigo AC, Napodano M, Cacciavillani L, Giovagnoni A, Renda P, De Biasio V, Plebani M, Mion M, Zaninotto M, Isabella G, Bilato C, Iliceto S. Postconditioning during coronary angioplasty in acute myocardial infarction: the POST-AMI trial. Int J Cardiol. 2012;162:33-38.
23. Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, Sanchez I, Bergerot C, Thibault H, Cung TT, Finet G, Argaud L, Revel D, Derumeaux G, Bonnefoy E, Elbaz M, Piot C, Ovize M, Croisille P. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012;59:2175-2181.
24. Freixa X, Bellera N, Ortiz-Pérez JT, Jimenez M, Pare C, Bosch X, De Caralt TM, Betriu A, Masotti M. Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary intervention. Eur Heart J. 2012;33:103-112.
25. Hahn J-Y, Song YB, Kim EK, Yu CW, Bae J-W, Chung W-Y, Choi S-H, Choi J-H, Bae J-H, An KJ, Park J-S, Oh JH, Kim S-W, Hwang J-Y, Ryu JK, Park HS, Lim D-S, Gwon H-C. Ischemic postconditioning during primary percutaneous coronary intervention. The effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction (POST) randomized trial. Circulation. 2013;128:1889-1896.
26. Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R. Postconditioning and protection from reperfusion injury: where do we stand? Cardiovasc Res. 2010;87:406-423.
27. Hausenloy DJ, Bøtker HE, Condorelli G, Ferdinandy P, Garcia-Dorado D, Heusch G, Lecour S, van Laake LW, Madonna R, Ruiz-Meana M, Schulz R, Sluijter JP, Yellon DM, Ovize M. Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res. 2013; 98:7-27.
28. Swarenstein M, Treweek S, Gagnier JJ, Altman DG, Tunis S, Haynes B, Oxman AD, Moher D. Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ. 2008;337:a2390.
29. Eitel I, Wöhrle J, Suenkel H, Meissner J, Kerber S, Lauer B, Pauschinger M, Birkemeyer R, Axthelm C, Zimmermann R, Neuhaus P, Brosteanu O, de Waha S, Desch S, Gutberlet M, Schuler G, Thiele H. Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention in ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2013;61:1447-1454.
30. Ibrahim T, Bülow HP, Hackl T, Hörnke M, Nekolla SG, Breuer M, Schömig A, Schwaiger M. Diagnostic value of contrast-enhanced magnetic resonance imaging and single-photon emission computed tomography for detection of myocardial necrosis early after acute myocardial infarction. J Am Coll Cardiol. 2007;49:208-216.
31. Heusch G. Cardioprotection: chances and challenges of its translation to the clinic. Lancet. 2013;381:166-175.