Engineered protein A ligands, derived from a histidine-scanning library, facilitate the affinity purification of IgG under mild acidic conditions

Journal of Biological Engineering

Volumn 8, Issue 1, 2014, Pages

  Tsukamoto, Masayuki ^a,c   Watanabe, Hideki ^b   Ooishi, Ayako ^b   Honda, Shinya ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c Manufacturing Technology Association of Biologics   (Japan)

Author keywords

Affinity purification; Antibody; Combinatorial screening; Histidine scanning Library; Staphylococcal protein A

Indexed keywords

AMINO ACID; HISTIDINE; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; LIGAND; STAPHYLOCOCCUS PROTEIN A;

ACIDIC CONDITION; ACIDITY; AFFINITY CHROMATOGRAPHY; ANTIBODY AFFINITY; ANTIBODY SCREENING; ARTICLE; BACTERIAL MUTATION; BACTERIOPHAGE T7; BINDING ASSAY; ENTAMOEBA COLI; FREQUENCY ANALYSIS; MEMBRANE DAMAGE; NONHUMAN; PHYSICAL PHENOMENA; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SURFACE PLASMON RESONANCE; THERMOSTABILITY;

EID: 84904665052     PISSN: None     EISSN: 17541611     Source Type: Journal    
DOI: 10.1186/1754-1611-8-15     Document Type: Article

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