Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.

Journal of the American Heart Association

Volumn 3, Issue 2, 2014, Pages

  Davies, Laura ^a   Jin, Jiawei ^b   Shen, Weijin ^b   Tsui, Hoyee ^b   Shi, Ying ^b   Wang, Yanwen ^b   Zhang, Yanmin ^b   Hao, Guoliang ^b   Wu, Jingjing ^b   Chen, S ^b   Fraser, James A ^b   Dong, Nianguo ^b   Christoffels, Vincent ^b   Ravens, Ursula ^b   Huang, Christopher L H ^b   Zhang, Henggui ^b   Cartwright, Elizabeth J ^b   Wang, Xin ^b   Lei, Ming ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; MAP2K4 PROTEIN, HUMAN; MAP2K4 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; TGFB1 PROTEIN, HUMAN; TGFB1 PROTEIN, MOUSE; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA1;

AGE; AGED; AGING; ANIMAL; ARTICLE; CARDIAC REMODELING; CASE CONTROL STUDY; CELL CULTURE; COMPUTER SIMULATION; DOWN REGULATION; DRUG EFFECT; ENZYMOLOGY; FEMALE; FIBROSIS; GENETIC TRANSFECTION; GENETICS; HEART ATRIUM FIBRILLATION; HEART ATRIUM REMODELING; HEART MUSCLE CELL; HEART RATE; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

AGING; ATRIAL FIBRILLATION; CARDIAC REMODELING;

AGE FACTORS; AGED; ANGIOTENSIN II; ANIMALS; ATRIAL FIBRILLATION; ATRIAL REMODELING; CASE-CONTROL STUDIES; CELLS, CULTURED; COMPUTER SIMULATION; DOWN-REGULATION; FEMALE; FIBROSIS; HEART RATE; HUMANS; MALE; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84904636479     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000340     Document Type: Article

References (0)