Role of bicyclol in preventing chemotherapeutic agent-induced liver injury in patients over 60 years of age with cancer

Journal of International Medical Research

Volumn 42, Issue 4, 2014, Pages 906-914

  Li, Xiaoyuan ^a   Zhou, Jianfeng ^a   Chen, Shuchang ^a   Guan, Mei ^a   Wang, Yingyi ^a   Zhao, Lin ^a   Ying, Hongyan ^a   Zhou, Yanping ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Bicyclol; cancer; chemotherapy induced liver injury; elderly people; hepatic injury; prophylaxis

Indexed keywords

4,4' DIMETHOXY 5,6,5',6' DIMETHYLENE DIOXY 2 HYDROXYMETHYL 2' CARBONYLBIPHENYL; ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIPHENYL DERIVATIVE; DOCETAXEL; ETOPOSIDE; FLUOROPYRIMIDINE; GEMCITABINE; IRINOTECAN; LIVER PROTECTIVE AGENT; OXALIPLATIN; PACLITAXEL; UNCLASSIFIED DRUG; BICYCLOL;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CANCER CHEMOTHERAPY; CONTROL GROUP; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; MAJOR CLINICAL STUDY; MALE; NEOPLASM; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; SIDE EFFECT; VERY ELDERLY; BLOOD; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG EFFECTS; LIVER; LIVER FUNCTION TEST; MIDDLE AGED; NEOPLASMS; PATHOLOGY; PRE-EXPOSURE PROPHYLAXIS; PROCEDURES; PROSPECTIVE STUDY;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BILIRUBIN; BIPHENYL COMPOUNDS; CHEMICAL AND DRUG INDUCED LIVER INJURY; FEMALE; HUMANS; LIVER; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; NEOPLASMS; PRE-EXPOSURE PROPHYLAXIS; PROSPECTIVE STUDIES; TRANSAMINASES;

EID: 84904631365     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060514527058     Document Type: Article

References (22)

1. Lee WM.Drug-induced hepatotoxicity.N Engl J Med. 1995;333:1118-1127.
2. Ishak KG,Zimmerman HJ.Morphologic spectrum of drug-induced hepatic disease.Gastroenterol Clin North Am. 1995;24:759-786.
3. Navarro VJ,Senior JR.Drug-related hepatotoxicity.N Engl J Med. 2006;354:731-739.
4. Venook AP,Egorin MJ,Rosner GL,et al.Phase I and pharmacokinetic trial of paclitaxel in patients with hepatic dysfunction: Cancer and Leukemia Group B 9264.J Clin Oncol. 1998;16:1811-1819.
5. Seidman AD,Hochhauser D,Gollub M,et al.Ninety-six-hour paclitaxel infusion after progression during short taxane exposure: a phase II pharmacokinetic and pharmacodynamic study in metastatic breast cancer.J Clin Oncol. 1996;14:1877-1884.
6. Johnson PJ,Dobbs N,Kalayci C,et al.Clinical efficacy and toxicity of standard dose adriamycin in hyperbilirubinaemic patients with hepatocellular carcinoma: relation to liver tests and pharmacokinetic parameters.Br J Cancer. 1992;65:751-755.
7. Mehta NN,Ravikumar R,Coldham CA,et al.Effect of preoperative chemotherapy on liver resection for colorectal liver metastases.Eur J Surg Oncol. 2008;34:782-786.
8. Sawhney R,Sehl M,Naeim A.Physiologic aspects of aging: impact on cancer management and decision making, part I.Cancer J. 2005;11:449-460.
9. Sehl M,Sawhney R,Naeim A.Physiologic aspects of aging: impact on cancer management and decision making, part II.Cancer J. 2005;11:461-473.
10. Zhao L,Ying H,Wang Y,et al.Clinical analysis of chemotherapeutic hepatotoxicity in the elderly cancer patients.Oncol Prog. 2010;8:602-606.
11. Liu GT.Bicyclol: a novel drug for treating chronic viral hepatitis B and C.Med Chem. 2009;5:29-43.
12. Ruan B,Wang JW,Bai XL.Comparison of bicyclol therapy for patients with genotype B and C of hepatitis B virus.Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007;21:366-368.
13. Ni Q,Tian-Sheng X,Min-Wei L,et al.Efficacy of combination therapy with peginterferon alfa-2alpha and bicyclol in chronic hepatitis B with high ALT levels.Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012;26:114-116.
14. Zhang WJ,Cai SP,Fan ZP,et al.The clinical efficacy and safety of adefovir dipivoxil in combination with bicyclol for the treatment of senior patients with chronic hepatitis B.Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011;25:453-456.
15. Yu YN,Chen H,Li Y.Effect of bicyclol on cisplatin-induced hepatotoxicity in the hepatocarcinoma 22 tumour-bearing mice.Basic Clin Pharmacol Toxicol. 2009;104:300-305.
16. Zhou J,Chen S,Bai C,et al.Effect of bicyclol in the prevention and treatment on the liver injury caused by anti-tumor agents.Chin Hepatol. 2007;12:286-287.
17. Tian C,Han L,Sun Y.Effect of tiopronin in the prevention and treatment of the hepatotoxicity caused by anti-tumor agents in cancer patients.Modern Oncology. 2007;15:706-708.
18. Santini D,Vincenzi B,Massacesi C,et al.S-adenosylmethionine (AdoMet) supplementation for treatment of chemotherapy-induced liver injury.Anticancer Res. 2003;23:5173-5179.
19. Mikalauskas S,Mikalauskiene L,Bruns H,et al.Dietary glycine protects from chemotherapy-induced hepatotoxicity.Amino Acids. 2011;40:1139-1150.
20. Vincenzi B,Santini D,Frezza AM,et al.The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retrospective analysis in patients affected by resected colorectal cancer treated with adjuvant FOLFOX regimen.Expert Opin Drug Saf. 2011;10:345-349.
21. Vincenzi B,Daniele S,Frezza AM,et al.The role of S-adenosylmethionine in preventing oxaliplatin-induced liver toxicity: a retrospective analysis in metastatic colorectal cancer patients treated with bevacizumab plus oxaliplatin-based regimen.Support Care Cancer. 2012;20:135-139.
22. Cleary JM,Tanabe KT,Lauwers GY,et al.Hepatic toxicities associated with the use of preoperative systemic therapy in patients with metastatic colorectal adenocarcinoma to the liver.Oncologist. 2009;14:1095-1105.