Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1

Biochemical Journal

Volumn 462, Issue 1, 2014, Pages 133-142

  Harmer, Stephen C ^a   Mohal, Jagdeep S ^a   Royal, Alice A ^a   McKenna, William J ^b   Lambiase, Pier D ^b   Tinker, Andrew ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Arrhythmia; Endoplasmic reticulum; Kv7.1; Potassium channel; Potassium voltage gated channel Isk related family member 1 (KCNE1); Trafficking

Indexed keywords

POTASSIUM CHANNEL KCNQ1;

ANIMAL CELL; ARTICLE; CASE REPORT; CONFOCAL MICROSCOPY; DISEASE SEVERITY; ELECTROCARDIOGRAM; FEMALE; GENE MUTATION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LONG QT SYNDROME 1; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TRANSPORT; QT PROLONGATION; WHOLE CELL PATCH CLAMP;

ANIMALS; ARRHYTHMIAS, CARDIAC; CHO CELLS; CRICETULUS; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 84904628972     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140425     Document Type: Article

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