Estimating heritability of drug-induced liver injury from common variants and implications for future study designs

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Overby, Casey Lynnette ^a,c   Hripcsak, George ^a   Shen, Yufeng ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Department of Systems Biology Columbia University ^*  (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAMASE INHIBITOR; FLUCLOXACILLIN;

CASE CONTROL STUDY; CHROMOSOME 6; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; TOXIC HEPATITIS;

AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; BETA-LACTAMASE INHIBITORS; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 6; DRUG-INDUCED LIVER INJURY; FLOXACILLIN; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS;

EID: 84904621801     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05762     Document Type: Article

References (19)

1. Jorgensen, A. L. ,Williamson, P. R. Methodological quality of pharmacogenetic studies: issues of concern. Stat Med 27, 6547-6569, doi:10.1002/sim.3420 (2008).
2. Daly, A. K. et al. HLA-B 5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet 41, 816-819, doi:10.1038/ng.379 (2009).
3. Collins, F. S., Guyer, M. S. & Charkravarti, A. Variations on a theme: cataloging human DNA sequence variation. Science 278, 1580-1581 (1997). (Pubitemid 27516268)
4. McCarthy, M. I. et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9, 356-369, doi:10.1038/nrg2344 (2008). (Pubitemid 351556063)
5. Maher, B. Personal genomes: The case of the missing heritability. Nature 456, 18-21, doi:10.1038/456018a (2008).
6. Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753, doi:10.1038/nature08494 (2009).
7. Yang, J. et al. Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42, 565-569, doi:10.1038/ng.608 (2010).
8. Malhotra, A. K., Murphy, G. M., Jr. & Kennedy, J. L. Pharmacogenetics of psychotropic drug response. Am J Psychiatry 161, 780-796 (2004). (Pubitemid 38625331)
9. Visscher, P. M., Brown, M. A., McCarthy, M. I. & Yang, J. Five years of GWAS discovery. Am J Hum Genet 90, 7-24, doi:10.1016/j.ajhg.2011.11.029 (2012).
10. Hyttinen, V., Kaprio, J., Kinnunen, L., Koskenvuo, M. & Tuomilehto, J. Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes 52, 1052-1055 (2003). (Pubitemid 36384278)
11. Polychronakos, C. & Li, Q. Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet 12, 781-792, doi:10.1038/nrg3069 (2011).
12. Anderson, C. A. et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43, 246-252, doi:10.1038/ng.764 (2011).
13. Lucena, M. I. et al. Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology 141, 338-347, doi:10.1053/j.gastro.2011.04.001 (2011).
14. Lee, S. H., Wray, N. R., Goddard, M. E. & Visscher, P. M. Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 88, 294-305, doi:10.1016/j.ajhg.2011.02.002 (2011).
15. Danan, G.& Benichou, C. Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 46, 1323-1330 (1993). (Pubitemid 23333873)
16. Bjornsson, E. S., Bergmann, O. M., Bjornsson, H. K., Kvaran, R. B. & Olafsson, S. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology 144, 1419-1425, 1425 e1411-1413; quiz e1419-1420, doi:10.1053/j.gastro.2013.02.006 (2013).
17. Larrey, D. Epidemiology and individual susceptibility to adverse drug reactions affecting the liver. Seminars in liver disease 22, 145-155, doi:10.1055/s-2002-30105 (2002). (Pubitemid 34496468)
18. Nejentsev, S. et al. Localization of type 1 diabetes susceptibility to theMHC class I genes HLA-B and HLA-A. Nature 450, 887-892, doi:10.1038/ nature06406 (2007). (Pubitemid 350231332)
19. Centers for Disease Control and Prevention, "CDC-Data Sources, References, and Methods-2011 National Diabetes Fact Sheet-Publications-Diabetes DDT", ,http://www.cdc.gov/diabetes/pubs/references11.htm. (2011). (Date of access: 3/26/2014).