Periaortic brown adipose tissue as a major determinant of [ 18F]-fluorodeoxyglucose vascular uptake in atherosclerosis-prone, ApoE-/- mice

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Toczek, Jakub ^a   Broisat, Alexis ^a   Perret, Pascale ^a   Desruet, Marie Dominique ^a   Fagret, Daniel ^a   Riou, Laurent M ^a   Ghezzi, Catherine ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; PROPRANOLOL; APOLIPOPROTEIN E; RADIOPHARMACEUTICAL AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ARCH; AORTA ATHEROSCLEROSIS; AORTA WALL; ARTICLE; AUTORADIOGRAPHY; BLOOD; BROWN ADIPOSE TISSUE; CAMERA; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; EX VIVO STUDY; IMAGE ANALYSIS; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; THORACIC AORTA; ANIMAL; AORTA; ATHEROSCLEROSIS; BODY WEIGHT; FEMALE; GENETICS; KNOCKOUT MOUSE; SCINTISCANNING; TISSUE DISTRIBUTION;

ADIPOSE TISSUE, BROWN; ANIMALS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BODY WEIGHT; FEMALE; FLUORODEOXYGLUCOSE F18; MICE; MICE, KNOCKOUT; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 84904604257     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099441     Document Type: Article

References (38)

1. Falk E, Nakano M, Bentzon JF, Finn AV, Virmani R (2013) Update on acute coronary syndromes: the pathologists' view. Eur Heart J 34: 719-728. doi:10.1093/eurheartj/ehs411.
2. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, et al. (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 108: 1664-1672. doi:10.1161/01.CIR. 0000087480.94275.97. (Pubitemid 37243650)
3. Rudd JHF, Warburton EA, Fryer TD, Jones HA, Clark JC, et al. (2002) Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 105: 2708-2711. (Pubitemid 34615139)
4. Sheikine Y, Akram K (2010) FDG-PET imaging of atherosclerosis: Do we know what we see? Atherosclerosis 211: 371-380. doi:10.1016/j.atherosclerosis. 2010.01.002.
5. Rosenbaum D, Millon A, Fayad ZA (2012) Molecular imaging in atherosclerosis: FDG PET. Curr Atheroscler Rep 14: 429-437. doi:10.1007/s11883- 012-0264-x.
6. Matter CM, Wyss MT, Meier P, Späth N, von Lukowicz T, et al. (2006) 18F-choline images murine atherosclerotic plaques ex vivo. Arterioscler Thromb Vasc Biol 26: 584-589. doi:10.1161/01.ATV.0000200106.34016.18.
7. Laurberg JM, Olsen AK, Hansen SB, Bottcher M, Morrison M, et al. (2007) Imaging of vulnerable atherosclerotic plaques with FDG-microPET: no FDG accumulation. Atherosclerosis 192: 275-282. doi:10.1016/j.atherosclerosis. 2006.07.019.
8. Rudd JHF, Fayad ZA, Machac J, Weissberg PL, Davies JR, et al. (2007) Response to "Laurberg JM, Olsen AK, Hansen SB, et al. Imaging of vulnerable atherosclerotic plaques with FDG-microPET: no FDG accumulation" [Atherosclerosis 2006]. Atherosclerosis 192: 453-454; author reply 451-452. doi:10.1016/j.atherosclerosis.2006.10.027.
9. Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, et al. (2008) Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation 117: 379-387. doi:10.1161/CIRCULATIONAHA.107.741181.
10. Hag AMF, Pedersen SF, Christoffersen C, Binderup T, Jensen MM, et al. (2012) (18)F-FDG PET imaging of murine atherosclerosis: association with gene expression of key molecular markers. PLoS ONE 7: e50908. doi:10.1371/journal. pone.0050908.
11. Wenning C, Kloth C, Kuhlmann MT, Jacobs AH, Schober O, et al. (2014) Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Atherosclerosis 234: 276-282. doi:10.1016/j.atherosclerosis.2014.03.008.
12. Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84: 277-359. doi:10.1152/physrev.00015. 2003. (Pubitemid 38054374)
13. Nedergaard J, Bengtsson T, Cannon B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293: E444-E452. doi:10.1152/ajpendo.00691.2006. (Pubitemid 47205086)
14. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, et al. (2009) Identification and Importance of Brown Adipose Tissue in Adult Humans. New England Journal of Medicine 360: 1509-1517. doi:10.1056/NEJMoa0810780.
15. Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, et al. (2011) Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol 301: H1425-H1437. doi:10.1152/ajpheart.00376.2011.
16. Chang L, Villacorta L, Li R, Hamblin M, Xu W, et al. (2012) Loss of Perivascular Adipose Tissue on Peroxisome Proliferator-Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis. Circulation 126: 1067-1078. doi:10.1161/CIRCULATIONAHA. 112.104489.
17. Wait JMS, Tomita H, Burk LM, Lu J, Zhou OZ, et al. (2013) Detection of Aortic Arch Calcification in Apolipoprotein E-Null Mice Using Carbon Nanotube-Based Micro-CT System. J Am Heart Assoc 2: e003358. doi:10.1161/JAHA.112.003358.
18. Fueger BJ, Czernin J, Hildebrandt I, Tran C, Halpern BS, et al. (2006) Impact of animal handling on the results of 18F-FDG PET studies in mice. J Nucl Med 47: 999-1006. (Pubitemid 46939953)
19. Toyama H, Ichise M, Liow J-S, Vines DC, Seneca NM, et al. (2004) Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET. Nucl Med Biol 31: 251-256. doi:10.1016/S0969-8051(03) 00124-0. (Pubitemid 38315120)
20. Lee K-H, Ko B-H, Paik J-Y, Jung K-H, Choe YS, et al. (2005) Effects of anesthetic agents and fasting duration on 18F-FDG biodistribution and insulin levels in tumor-bearing mice. J Nucl Med 46: 1531-1536. (Pubitemid 46173264)
21. Arch JR, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, et al. (1984) Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309: 163-165. (Pubitemid 14142787)
22. Tatsumi M, Engles JM, Ishimori T, Nicely O, Cohade C, et al. (2004) Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically. J Nucl Med 45: 1189-1193. (Pubitemid 47611664)
23. Fonseca VA (2010) Effects of beta-blockers on glucose and lipid metabolism. Curr Med Res Opin 26: 615-629. doi:10.1185/03007990903533681.
24. Silvola JMU, Saraste A, Laitinen I, Savisto N, Laine VJO, et al. (2011) Effects of age, diet, and type 2 diabetes on the development and FDG uptake of atherosclerotic plaques. JACC Cardiovasc Imaging 4: 1294-1301. doi:10.1016/j.jcmg.2011.07.009.
25. Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, et al. (2011) Localization of deoxyglucose and annexin A5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion. Mol Imaging Biol 13: 712-720. doi:10.1007/s11307-010-0389-7.
26. Folco EJ, Sheikine Y, Rocha VZ, Christen T, Shvartz E, et al. (2011) Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-Dglucose positron emission tomography. J Am Coll Cardiol 58: 603-614. doi:10.1016/j.jacc.2011.03.044.
27. Ogawa M, Nakamura S, Saito Y, Kosugi M, Magata Y (2012) What can be seen by 18F-FDG PET in atherosclerosis imaging? The effect of foam cell formation on 18F-FDG uptake to macrophages in vitro. J Nucl Med 53: 55-58. doi:10.2967/jnumed.111.092866.
28. Camici PG, Rimoldi OE, Gaemperli O, Libby P (2012) Non-invasive anatomic and functional imaging of vascular inflammation and unstable plaque. Eur Heart J 33: 1309-1317. doi:10.1093/eurheartj/ehs067.
29. Cohade C, Osman M, Pannu HK, Wahl RL (2003) Uptake in Supraclavicular Area Fat ("USA-Fat"): Description on 18F-FDG PET/CT. J Nucl Med 44: 170-176.
30. Bauwens M, Wierts R, van Royen B, Bucerius J, Backes W, et al. (2014) Molecular imaging of brown adipose tissue in health and disease. Eur J Nucl Med Mol Imaging 41: 776-791. doi:10.1007/s00259-013-2611-8.
31. Vosselman MJ, van Marken Lichtenbelt WD, Schrauwen P (2013) Energy dissipation in brown adipose tissue: From mice to men. Molecular and Cellular Endocrinology 379: 43-50. doi:10.1016/j.mce.2013.04.017.
32. Falk E, Thim T, Kristensen IB (2009) Atherosclerotic Plaque, Adventitia, Perivascular Fat, and Carotid Imaging. J Am Coll Cardiol Img 2: 183-186. doi:10.1016/j.jcmg.2008.11.005.
33. Chatterjee TK, Stoll LL, Denning GM, Harrelson A, Blomkalns AL, et al. (2009) Proinflammatory phenotype of perivascular adipocytes influence of highfat feeding. Circulation research 104: 541-549.
34. Rudd JHF, Myers KS, Bansilal S, Machac J, Pinto CA, et al. (2008) Atherosclerosis Inflammation Imaging with 18F-FDG PET: Carotid, Iliac, and Femoral Uptake Reproducibility, Quantification Methods, and Recommendations. J Nucl Med 49: 871-878. doi:10.2967/jnumed.107.050294. (Pubitemid 351793426)
35. Fayad ZA, Mani V, Woodward M, Kallend D, Abt M, et al. (2011) Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial. The Lancet 378: 1547-1559. doi:10.1016/S0140-6736(11)61383-4.
36. Tawakol A, Fayad ZA, Mogg R, Alon A, Klimas MT, et al. (2013) Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose- positron emission tomography/computed tomography feasibility study. J Am Coll Cardiol 62: 909-917. doi:10.1016/j.jacc.2013.04.066.
37. Cheng VY, Slomka PJ, Meunier LL, Tamarappoo BK, Nakazato R, et al. (2012) Coronary Arterial 18F-FDG Uptake by Fusion of PET and Coronary CT Angiography at Sites of Percutaneous Stenting for Acute Myocardial Infarction and Stable Coronary Artery Disease. J Nucl Med 53: 575-583. doi:10.2967/jnumed.111.097550.
38. Joshi NV, Vesey AT, Williams MC, Shah ASV, Calvert PA, et al. (2014) 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. The Lancet 383: 705-713. doi:10.1016/S0140-6736(13)61754-7.