Genetic risks link autoimmune hepatitis to other autoimmune liver disease

Gastroenterology

Volumn 147, Issue 2, 2014, Pages 270-273

  Hirschfield, Gideon M ^a   Karlsen, Tom Hemming ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERFERON REGULATORY FACTOR 5; STAT4 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

AUTOIMMUNE HEPATITIS; AUTOIMMUNE LIVER DISEASE; EDITORIAL; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; IMMUNOPHENOTYPING; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AUTOIMMUNITY; FEMALE; HEPATITIS, AUTOIMMUNE; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84904602832     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.06.020     Document Type: Editorial

References (20)

1. A.J. Czaja, and M.P. Manns Advances in the diagnosis, pathogenesis, and management of autoimmune hepatitis Gastroenterology 139 2010 58 72
2. P.J. Trivedi, and G.M. Hirschfield Treatment of autoimmune liver disease: current and future therapeutic options Ther Adv Chronic Dis 4 2013 119 141
3. K.M. Boberg, R.W. Chapman, and G.M. Hirschfield et al. Overlap syndromes: the International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue J Hepatol 54 2011 374 385
4. E. Hintermann, M. Holdener, and M. Bayer et al. Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model J Autoimmun 37 2011 242 253
5. Y.S. de Boer, N.M.F. van Gerven, and A. Zwiers et al. Genome-wide association study identifies variants associated with autoimmune hepatitis type 1 Gastroenterology 147 2014 443 452
6. M.S. Longhi, R. Liberal, and B. Holder et al. Inhibition of interleukin-17 promotes differentiation of CD25(-) cells into stable T regulatory cells in patients with autoimmune hepatitis Gastroenterology 142 2012 1526 1535
7. C.R. Grant, R. Liberal, and B.S. Holder et al. Dysfunctional CD39(POS) regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis Hepatology 59 2014 1007 1015
8. A.J. Bonito, C. Aloman, and M.I. Fiel et al. Medullary thymic epithelial cell depletion leads to autoimmune hepatitis J Clin Invest 123 2013 3510 3524
9. M.H. Cheng, and M.S. Anderson Monogenic autoimmunity Annu Rev Immunol 30 2012 393 427
10. G.F. Mells, A. Kaser, and T.H. Karlsen Novel insights into autoimmune liver diseases provided by genome-wide association studies J Autoimmun 46 2013 41 54
11. G.M. Hirschfield, X. Liu, and C. Xu et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants N Engl J Med 360 2009 2544 2555
12. T.H. Karlsen, A. Franke, and E. Melum et al. Genome-wide association analysis in primary sclerosing cholangitis Gastroenterology 138 2010 1102 1111
13. L.A. Hindorff, P. Sethupathy, and H.A. Junkins et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits Proc Natl Acad Sci U S A 106 2009 9362 9367
14. V. Orru, M. Steri, and G. Sole et al. Genetic variants regulating immune cell levels in health and disease Cell 155 2013 242 256
15. J.Z. Liu, J.R. Hov, and T. Folseraas et al. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis Nat Genet 45 2013 670 675
16. A. Zhernakova, C.C. van Diemen, and C. Wijmenga Detecting shared pathogenesis from the shared genetics of immune-related diseases Nat Rev Genet 10 2009 43 55
17. P. Price, C. Witt, and R. Allcock et al. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases Immunol Rev 167 1999 257 274
18. L.M. Sollid, and E. Thorsby HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis Gastroenterology 105 1993 910 922
19. A. Blomhoff, M. Olsson, and S. Johansson et al. Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes Genes Immun 7 2006 130 140
20. L.M. Sollid, and B. Jabri Triggers and drivers of autoimmunity: lessons from coeliac disease Nat Rev Immunol 13 2013 294 302