Martentoxin, a large-conductance Ca2+-activated K+ channel inhibitor, attenuated TNF-α-induced nitric oxide release by human umbilical vein endothelial cells

Journal of Biomedical Research

Volumn 27, Issue 5, 2013, Pages 386-393

  Wang, Jun ^a   Qian, Wenyi ^a   Zhu, Qing ^a   Chen, Jian ^a   Huan, Fei ^a   Gao, Rong ^a   Xiao, Hang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Buthus martensii karsch; Human umbilical vein endothelial cells (HUVECs); Martentoxin; Nitric oxide

Indexed keywords

EID: 84904599237     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.7555/JBR.27.20120080     Document Type: Article

References (29)

1. Liu YF, Ma RL, Wang SL, Duan ZY, Zhang JH, Wu LJ, et al. Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli. Protein Expr Purif 2003; 27: 253-8.
2. Liang S. An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)], Toxicon 2004; 43: 575-85.
3. Stuehr DJ. Mammalian nitric oxide synthases. Biochim Biophys Acta 1999; 1411: 217-30.
4. Stuehr DJ, Santolini J, Wang ZQ, Wei CC, Adak S. Update on mechanism and catalytic regulation in the NO synthases. J Biol Chem 2004; 279: 36167-170.
5. Stuehr DJ, Griffith OW. Mammalian nitric oxide syn-thases. Adv Enzymol Relat Areas Mol Biol 1992; 65: 287-346.
6. Busse R, LückhoffA, Mülsch A. Cellular mechanisms controlling EDRF/NO formation in endothelial cells. Basic Res Cardiol 1991; 86 (S2): 7-16.
7. Jin UH, Kim KS, Park SY, Chung KH, Kim DS, Chang YC, et al. Effect of Buthus martensi Karsch on aro-matase activity and cytokine-inducted NOS and NO production in osteoblasts and leukaemic cell line FLG 29.1. Immunopharmacol Immunotoxicol 2006; 28: 241-58.
8. Cao ZY, Shen WQ, Pan YP, Xiao X, Liu XM, Wang XL, et al. Purification, characterization of two peptides from Buthus martensi Karch. J Pept Res 2003; 62: 252-9.
9. Wang Y, Chen X, Zhang N, Wu G, Wu H. The solution structure of BmTx3B, a member of the scorpion toxin subfamily alpha-KTx 16. Proteins 2005; 58: 489-97.
10. Wang YH, Cao ZY, He WY, Yan XZ, Liu X, Liu HY, et al. 1H-NMR signal assignments and secondary structure analysis of martentoxin. J Asian Nat Prod Res 2006; 8: 511-8.
11. Shi J, He HQ, Zhao R, Duan YH, Chen J, Chen Y, et al. Inhibition of martentoxin on neuronal BK channel sub-type (alpha+beta4): implications for a novel interaction model. Biophys J 2008; 94: 3706-13.
12. Ledoux J, Werner ME, Brayden JE, Nelson MT. Calcium-activated potassium channels and the regu-lation of vascular tone. Physiology (Bethesda) 2006; 21: 69-78.
13. Kestler HA, Janko S, Häussler U, Muche R, Hombach V, Höher M, et al. A remark on the high-conductance calcium-activated potassium channel in human endothe-lial cells. Res Exp Med (Berl) 1998; 198: 133-43.
14. Jaffe EA, Grulich J, Weksler BB, Hampel G, Watanabe K. Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells. J Biol Chem 1987; 262: 8557-65.
15. Uchihara T, Kondo H, Akiyama H, Ikeda K. Single-laser three-color immunolabeling of a histological section by laser scanning microscopy: application to senile plaque-related structures in post-mortem human brain tissue. J Histochem Cytochem 1995; 43: 103-6.
16. al-Mohanna F, Collison K, Parhar R, Kwaasi A, Meyer B, Saleh S, et al. Activation of naive xenogeneic but not allogeneic endothelial cells by human naive neutrophils: a potential occult barrier to xenotransplantation. Am J Pathol 1997; 151: 111-20.
17. Urbán Z, Riazi S, Seidl TL, Katahira J, Smoot LB, Chi-tayat D, et al. Connection between elastin haploinsuf-ficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syn-drome. Am J Hum Genet 2002; 71: 30-44.
18. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, ni-trite, and [15N] nitrate in biological fluids. Anal Biochem 1982; 126: 131-8.
19. Sheng L, Qian Z, Shi Y, Yang L, Xi L, Zhao B, et al. Crocetin improves the insulin resistance induced by high-fat diet in rats. Br J Pharmacol 2008; 154: 1016-24.
20. Li QS, Liu Y, Feng ZJ, Lu ZS, Qian MZ. The molecular mechanism of apoptosis of human umbilical vein en-dothelial cells induced by monocyte chemotacitic pro-tein-1. Sheng Li Xue Bao 2010; 62: 63-8.
21. Aktan F. iNOS-mediated nitric oxide production and its regulation. Life Sci 2004; 75: 639-53.
22. Gao X, Xu X, Belmadani S, Park Y, Tang Z, Feldman AM, et al. TNF-alpha contributes to endothelial dys-function by upregulating arginase in ischemia/reper-fusion injury. Arterioscler Thromb Vasc Biol 2007; 27: 1269-75.
23. Vang A, Mazer J, Casserly B, Choudhary G. Activation of endothelial BKCa channels causes pulmonary vasodi-lation. Vascul Pharmacol 2010; 53: 122-9.
24. SalkoffL, Butler A, Ferreira G, Santi C, Wei A. High-conductance potassium channels of the SLO family. Nat Rev Neurosci 2006; 7: 921-31.
25. Hama S, Takeichi O, Fujisaki K, Tanabe N, Maeno M, Ochiai K. Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation. Clin Exp Immunol 2008; 154: 384-90.
26. Chakrabarti S, Chan CK, Jiang Y, Davidge ST. Neuronal nitric oxide synthase regulates endothelial inflammation. J Leukoc Biol 2012; 91: 947-56.
27. Zemse SM, Chiao CW, Hilgers RH, Webb RC. Inter-leukin-10 inhibits the in vivo and in vitro adverse effects of TNF-alpha on the endothelium of murine aorta. Am J Physiol Heart Circ Physiol 2010; 299: H1160-7.
28. Xu H, Wang Y, Garver H, Galligan JJ, Fink GD. Vascular BK channel deficiency exacerbates organ damage and mortality in endotoxemic mice. J Cardiovasc Pharmacol 2012, 59: 207-14.
29. Tao J, Shi J, Yan L, Chen Y, Duan YH, Ye P, et al. Enhancement effects of martentoxin on glioma BK channel and BK channel (α+β1) subtypes. PLoS One 2011, 6: e15896.