Nomogram to predict ypN status after chemoradiation in patients with locally advanced rectal cancer

British Journal of Cancer

Volumn 111, Issue 2, 2014, Pages 249-254

  Jwa, E ^a   Kim, J H ^a   Han, S ^a   Park, J H ^a   Lim, S B ^a   Kim, J C ^a   Hong, Y S ^a   Kim, T W ^a   Yu, C S ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

lymph node; nomogram; preoperative chemoradiotherapy; rectal cancer

Indexed keywords

CAPECITABINE; FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER STAGING; CHEMORADIOTHERAPY; FEMALE; HUMAN; LOCALLY ADVANCED RECTAL CANCER; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; NOMOGRAM; ONCOLOGICAL PARAMETERS; PELVIC LYMPH NODE STATUS; PERINEURAL INVASION; PREOPERATIVE CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECTUM CANCER; TUMOR DIFFERENTIATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CHEMORADIOTHERAPY; FEMALE; HUMANS; LOGISTIC MODELS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; NOMOGRAMS; PREDICTIVE VALUE OF TESTS; PREOPERATIVE CARE; RECTAL NEOPLASMS; YOUNG ADULT;

EID: 84904571852     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.256     Document Type: Article

References (28)

1. AJCC (2010) AJCC Cancer Staging Manual. In Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL, Torotti A (eds) 7th edn. Springer-Verlag: New York, NY.
2. Belluco C, De Paoli A, Canzonieri V, Sigon R, Fornasarig M, Buonadonna A, Boz G, Innocente R, Perin T, Cossaro M, Polesel J, De Marchi F (2011) Long-term outcome of patients with complete pathologic response after neoadjuvant chemoradiation for cT3 rectal cancer: implications for local excision surgical strategies. Ann Surg Oncol 18: 3686-3693.
3. Borschitz T, Wachtlin D, Mohler M, Schmidberger H, Junginger T (2008) Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer. Ann Surg Oncol 15: 712-720.
4. Bujko K, Richter P, Smith FM, Polkowski W, Szczepkowski M, Rutkowski A, Dziki A, Pietrzak L, Kolodziejczyk M, Kusnierz J, Gach T, Kulig J, Nawrocki G, Radziszewski J, Wierzbicki R, Kowalska T, Meissner W, Radkowski A, Paprota K, Polkowski M, Rychter A (2013) Preoperative radiotherapy and local excision of rectal cancer with immediate radical reoperation for poor responders: a prospective multicentre study. Radiother Oncol 106: 198-205.
5. Callender GG, Das P, Rodriguez-Bigas MA, Skibber JM, Crane CH, Krishnan S, Delclos ME, Feig BW (2010) Local excision after preoperative chemoradiation results in an equivalent outcome to total mesorectal excision in selected patients with T3 rectal cancer. Ann Surg Oncol 17: 441-447.
6. Chen Z, Liu Z, Deng X, Warden C, Li W, Garcia-Aguilar J (2012) Chromosomal copy number alterations are associated with persistent lymph node metastasis after chemoradiation in locally advanced rectal cancer. Dis Colon Rectum 55: 677-685.
7. Cho YB, Chun HK, Kim MJ, Choi JY, Park CM, Kim BT, Lee SJ, Yun SH, Kim HC, Lee WY (2009) Accuracy of MRI and 18F-FDG PET/CT for restaging after preoperative concurrent chemoradiotherapy for rectal cancer. World J Surg 33: 2688-2694.
8. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Wolff RA, Eng C, Krishnan S, Janjan NA, Crane CH (2007) Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer 109: 1750-1755.
9. Dworak O, Keilholz L, Hoffmann A (1997) Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 12: 19-23.
10. Folkesson J, Birgisson H, Pahlman L, Cedermark B, Glimelius B, Gunnarsson U (2005) Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 23: 5644-5650.
11. Greenberg JA, Shibata D, Herndon 2nd JE, Steele Jr GD, Mayer R, Bleday R (2008) Local excision of distal rectal cancer: an update of cancer and leukemia group B 8984. Dis Colon Rectum 51: 1185-1191.
12. Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143: 29-36.
13. Harrell FE (2012) rms: Regression Modeling Strategies. R package version 3.5-0. (Computer Program) http://CRAN.R-project.org/package=rms.
14. Harrell Jr FE, Califf RM, Pryor DB, Lee KL, Rosati RA (1982) Evaluating the yield of medical tests. JAMA 247: 2543-2546.
15. Hosmer DW, Lemeshow S (2000) Applied Logistic Regression. 2nd edn. Wiley: New York.
16. Hughes R, Glynne-Jones R, Grainger J, Richman P, Makris A, Harrison M, Ashford R, Harrison RA, Livingstone JI, McDonald PJ, Meyrick Thomas J, Mitchell IC, Northover JM, Phillips R, Wallace M, Windsor A, Novell JR (2006) Can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local recurrence and the appropriateness of local excision? Int J Colorectal Dis 21: 11-17.
17. Jin YJ, Lim YS, Han S, Lee HC, Hwang S, Lee SG (2012) Predicting survival after living and deceased donor liver transplantation in adult patients with acute liver failure. J Gastroenterol 47: 1115-1124.
18. Maas M, Nelemans PJ, Valentini V, Das P, Rodel C, Kuo LJ, Calvo FA, Garcia-Aguilar J, Glynne-Jones R, Haustermans K, Mohiuddin M, Pucciarelli S, Small Jr W, Suarez J, Theodoropoulos G, Biondo S, Beets-Tan RG, Beets GL (2010) Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 11: 835-844.
19. Park JH, Yoon SM, Yu CS, Kim JH, Kim TW, Kim JC (2011) Randomized phase 3 trial comparing preoperative and postoperative chemoradiotherapy with capecitabine for locally advanced rectal cancer. Cancer 117: 3703-3712.
20. Park JW, Lim SB, Kim DY, Jung KH, Hong YS, Chang HJ, Choi HS, Jeong SY (2009) Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery. Int J Radiat Oncol Biol Phys 74: 810-817.
21. Paun BC, Cassie S, MacLean AR, Dixon E, Buie WD (2010) Postoperative complications following surgery for rectal cancer. Ann Surg 251: 807-818.
22. Pomerri F, Pucciarelli S, Maretto I, Zandona M, Del Bianco P, Amadio L, Rugge M, Nitti D, Muzzio PC (2011) Prospective assessment of imaging after preoperative chemoradiotherapy for rectal cancer. Surgery 149: 56-64.
23. Pucciarelli S, Capirci C, Emanuele U, Toppan P, Friso ML, Pennelli GM, Crepaldi G, Pasetto L, Nitti D, Lise M (2005) Relationship between pathologic T-stage and nodal metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer. Ann Surg Oncol 12: 111-116.
24. Rutten HJ, den Dulk M, Lemmens VE, van de Velde CJ, Marijnen CA (2008) Controversies of total mesorectal excision for rectal cancer in elderly patients. Lancet Oncol 9: 494-501.
25. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R. German Rectal Cancer Study G (2004) Preoperative vs postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351: 1731-1740.
26. Shivnani AT, Small Jr W, Stryker SJ, Kiel KD, Lim S, Halverson AL, Talamonti MS (2007) Preoperative chemoradiation for rectal cancer: results of multimodality management and analysis of prognostic factors. Am J Surg 193: 389-393.
27. Steinhagen E, Shia J, Riedel E, Nash GM, Weiser MR, Temple LK, Paty PB, Guillem JG (2013) Response to neoadjuvant therapy in patients with early age-of-onset rectal cancer. Dis Colon Rectum 56: 58-63.
28. Yoon SM, Kim DY, Kim TH, Jung KH, Chang HJ, Koom WS, Lim SB, Choi HS, Jeong SY, Park JG (2007) Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys 69: 1167-1172.