Association of genetic variants of vit D binding protein (DBP/GC) and of the enzyme catalyzing its 25-hydroxylation (DCYP2R1) and serum vit D in postmenopausal women

Hormones

Volumn 13, Issue 3, 2014, Pages 345-352

  Xu, Wen ^a   Sun, Jing ^a   Wang, Wenbo ^b   Wang, Xiran ^c   Jiang, Yan ^a   Huang, Wei ^d   Zheng, Xin ^e   Wang, Qiuping ^f   Ning, Zhiwei ^g   Pei, Yu ^h   Nie, Min ^a   Li, Mei ^a   Wang, Ou ^a   Xing, Xiaoping ^a   Yu, Wei ^a   Lin, Qiang ^a   Xu, Ling ^a   Xia, Weibo ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b PEKING UNIVERSITY SHOUGANG HOSPITAL   (China)

^c General Hospital of the Second Artillery Force   (China)

^d Beijing Haidian Hospital   (China)

^e CHINA REHABILITATION RESEARCH CENTER   (China)

^f Beijing Liangxiang Hospital   (China)

^g CAPITAL MEDICAL UNIVERSITY   (China)

^h CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Association analysis; BMD; Bone turnover markers; CYP2R1; GC; SNP; Vitamin D

Indexed keywords

CALCIFEDIOL; COLLAGEN TYPE 1; CYTOCHROME P450; CYTOCHROME P450 2R1; PROCOLLAGEN TYPE 1 AMINOPROPEPTIDE; PROTEIN PRECURSOR; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; BIOLOGICAL MARKER; CHOLESTANETRIOL 26 MONOOXYGENASE; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; CYP2R1 PROTEIN, HUMAN; PEPTIDE; PEPTIDE FRAGMENT; PROCOLLAGEN; PROCOLLAGEN TYPE I N-TERMINAL PEPTIDE;

ADULT; ARTICLE; AUTOMATION; BETACTX GENE; BONE DENSITY; BONE TURNOVER; CATALYSIS; CHINESE; COMMUNITY ASSESSMENT; DCYP2R1 GENE; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GC GENE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC MARKER; GENETIC PROCEDURES; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYDROXYLATION; LUMINESCENCE; MAJOR CLINICAL STUDY; P1NP GENE; POPULATION RESEARCH; POSTMENOPAUSE; SEASONAL VARIATION; SINGLE NUCLEOTIDE POLYMORPHISM; SPRING; SUMMER; TAQMAN ALLELIC DISCRIMINATION ASSAY; UPREGULATION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WINTER; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CHINA; ETHNOLOGY; GENETIC ASSOCIATION; GENETICS; HAPLOTYPE; MIDDLE AGED; PHENOTYPE; PHOTON ABSORPTIOMETRY; PREDICTIVE VALUE; RISK FACTOR; SEASON; TIME;

ABSORPTIOMETRY, PHOTON; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; BONE DENSITY; CALCIFEDIOL; CHINA; CHOLESTANETRIOL 26-MONOOXYGENASE; COLLAGEN TYPE I; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; MIDDLE AGED; PEPTIDE FRAGMENTS; PEPTIDES; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; PREDICTIVE VALUE OF TESTS; PROCOLLAGEN; RISK FACTORS; SEASONS; TIME FACTORS; VITAMIN D DEFICIENCY; VITAMIN D-BINDING PROTEIN;

EID: 84904539227     PISSN: 11093099     EISSN: None     Source Type: Journal    
DOI: 10.14310/horm.2002.1484     Document Type: Article

References (16)

1. Holick MF, 2011 Vitamin D deficiency in 2010: health benefits of vitamin D and sunlight: a D-bate. nat Rev endocrinol 7: 73-75.
2. Lu L, Yu Z, Pan A, et al, 2009 Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care 32: 1278-1283.
3. Holick MF, 2011 Vitamin D: a d-lightful solution for health. J Investig Med 59: 872-880.
4. Arguelles LM, Langman CB, Ariza AJ, et al, 2009 Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent twins. J Clin endocrinol Metab 94: 3273-3281.
5. Shea MK, Benjamin eJ, Dupuis J, et al, 2009 Genetic and non-genetic correlates of vitamins K and D. eur J Clin nutr 63: 458-464.
6. Snellman G, Melhus H, Gedeborg R, et al, 2009 Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study. PLoS One 4: e7747.
7. Fang Y, van Meurs JB, Arp P, et al, 2009 Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int 85: 85-93.
8. Strushkevich n, usanov SA, Plotnikov An, Jones G, Park HW, 2008 Structural analysis of CYP2R1 in complex with vitamin D3. J Mol Biol 380: 95-106.
9. Ahn J, Yu K, Stolzenberg-Solomon R, et al, 2010 Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 19: 2739-2745.
10. Wang TJ, Zhang F, Richards JB, et al, 2010 Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376: 180-188.
11. Bu FX, Armas L, Lappe J, et al, 2010 Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet 128: 549-56.
12. Zhao J, Xia W, nie M, et al, 2012 A haplotype of MATn3 is associated with vertebral fracture in Chinese postmenopausal women: Peking Vertebral Fracture (PK-VF) study. Bone 50: 917-924.
13. Purcell S, neale B, Todd-Brown K, et al, 2007 PLInK: a tool set for whole-genome association and populationbased linkage analyses. Am J Hum Genet 81: 559-575.
14. Abbas S, Linseisen J, Slanger T, et al, 2008 The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer epidemiol Biomarkers Prev 17: 1339-1343.
15. Lauridsen AL, Vestergaard P, Hermann AP, et al, 2005 Plasma concentrations of 25-hydroxy-vitamin D and 1, 25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif Tissue Int 77: 15-22.
16. Lu L, Sheng H, Li H, et al, 2012 Associations between common variants in GC and DHCR7/nADSYn1 and vitamin D concentration in Chinese Hans. Hum Genet 131: 505-512.