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Volumn 48, Issue 8, 2014, Pages 1030-1039

Levomilnacipran: A New Serotonin-Norepinephrine Reuptake Inhibitor for the Treatment of Major Depressive Disorder

Author keywords

antidepressants; central nervous system; depression; psychiatry; serotonin

Indexed keywords

ACETYLSALICYLIC ACID; BUSPIRONE; CARBAMAZEPINE; CLARITHROMYCIN; DESVENLAFAXINE; DULOXETINE; FENTANYL; HERBACEOUS AGENT; KETOCONAZOLE; LINEZOLID; LITHIUM; METHYLENE BLUE; MILNACIPRAN; NONSTEROID ANTIINFLAMMATORY AGENT; PHENELZINE; PLACEBO; RIFAMPICIN; RITONAVIR; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; TRIPTAN DERIVATIVE; TRYPTOPHAN; VENLAFAXINE; WARFARIN;

EID: 84904511898     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028014535074     Document Type: Review
Times cited : (10)

References (40)
  • 2
    • 84890245279 scopus 로고    scopus 로고
    • Pharmacological prevention of suicide in patients with major mood disorders
    • Rihmer Z,Gonda X.Pharmacological prevention of suicide in patients with major mood disorders.Neurosci Biobehav Rev. 2013;37:2398-2403.
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 2398-2403
    • Rihmer, Z.1    Gonda, X.2
  • 3
    • 84888155080 scopus 로고    scopus 로고
    • Animal models as tools to study the pathophysiology of depression
    • Abelaira HM,Reus GZ,Quevedo J.Animal models as tools to study the pathophysiology of depression.Rev Bras Psiquiatr. 2013;35:S112-S120.
    • (2013) Rev Bras Psiquiatr , vol.35
    • Abelaira, H.M.1    Reus, G.Z.2    Quevedo, J.3
  • 4
    • 80155189205 scopus 로고    scopus 로고
    • The noradrenergic symptom cluster: clinical expression and neuropharmacology
    • Blier P,Briley M.The noradrenergic symptom cluster: clinical expression and neuropharmacology.Neuropsychiatr Dis Treat. 2011;7:15-20.
    • (2011) Neuropsychiatr Dis Treat , vol.7 , pp. 15-20
    • Blier, P.1    Briley, M.2
  • 5
    • 46449102689 scopus 로고    scopus 로고
    • Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions
    • Guiard BP,Mansari ME,Merali Z,Blier P.Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions.Int J Neuropsychopharmacol. 2008;11:625-639.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 625-639
    • Guiard, B.P.1    Mansari, M.E.2    Merali, Z.3    Blier, P.4
  • 6
    • 84888410322 scopus 로고    scopus 로고
    • Neuroplasticity and the next wave of antidepressant strategies
    • Published November 20, 2013. Accessed December 12, 2013
    • HayleySLittlejohnD. Neuroplasticity and the next wave of antidepressant strategies. Front Cell Neurosci. 2013;7:218. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834236/. Published November 20, 2013. Accessed December 12, 2013.
    • (2013) Front Cell Neurosci. , vol.7 , pp. 218
    • Hayley, S.1    Littlejohn, D.2
  • 7
    • 0004137965 scopus 로고    scopus 로고
    • 3rd ed.Arlington, VA: American Psychiatric Association; 2010.;, Arlington, VA: American Psychiatric Association
    • Practice Guideline for the Treatment of Patients With Major Depressive Disorder. 3rd ed.Arlington, VA: American Psychiatric Association; 2010.Arlington, VA: American Psychiatric Association; 2010:.
    • (2010) Practice Guideline for the Treatment of Patients With Major Depressive Disorder
  • 8
    • 84904491226 scopus 로고    scopus 로고
    • Fetzima (levomilnacipran) [package insert].St Louis, MO: Forest Laboratories
    • Fetzima (levomilnacipran) [package insert].St Louis, MO: Forest Laboratories; 2013:.
    • (2013)
  • 9
    • 84904491227 scopus 로고    scopus 로고
    • Effect of 3-month treatment with F2695 (75mg OD) on improving functional recovery of patients with ischemic stroke: a multicenter, randomized, double-blind, parallel-group, placebo-controlled study Accessed April 30
    • Effect of 3-month treatment with F2695 (75mg OD) on improving functional recovery of patients with ischemic stroke: a multicenter, randomized, double-blind, parallel-group, placebo-controlled study. http://clinicaltrials.gov/show/NCT01639014. Accessed April 30, 2014.
    • (2014)
  • 10
    • 84876993979 scopus 로고    scopus 로고
    • Levomilnacipran (F2695), a norepinephrine-preferring SNRI: profile in vitro and in models of depression and anxiety
    • Auclair AL,Martel JC,Assie MD,et al.Levomilnacipran (F2695), a norepinephrine-preferring SNRI: profile in vitro and in models of depression and anxiety.Neuropharmacology. 2013;70:338-347.
    • (2013) Neuropharmacology , vol.70 , pp. 338-347
    • Auclair, A.L.1    Martel, J.C.2    Assie, M.D.3
  • 11
    • 84904491228 scopus 로고    scopus 로고
    • St Louis, MO: Forest Laboratories Inc
    • St Louis, MO: Forest Laboratories Inc; 2013:.
    • (2013)
  • 13
    • 84904491229 scopus 로고    scopus 로고
    • Philadelphia, PA: Pfizer Wyeth Pharmaceuticals Inc
    • Effexor XRPhiladelphia, PA: Pfizer Wyeth Pharmaceuticals Inc; 2012:.
    • (2012)
    • Effexor, X.R.1
  • 14
    • 84904491230 scopus 로고    scopus 로고
    • Dayton, NJ: Aurobindo Pharma USA
    • Dayton, NJ: Aurobindo Pharma USA; 2013:.
    • (2013)
  • 15
    • 84904491231 scopus 로고    scopus 로고
    • Philadelphia, PA: Pfizer Wyeth Pharmaceuticals Inc
    • Philadelphia, PA: Pfizer Wyeth Pharmaceuticals Inc; 2013:.
    • (2013)
  • 16
    • 33745958408 scopus 로고    scopus 로고
    • Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor
    • Deecher DC,Beyer CE,Johnston G,et al.Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor.J Pharmacol Exp Ther. 2006;318:657-665.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 657-665
    • Deecher, D.C.1    Beyer, C.E.2    Johnston, G.3
  • 17
    • 84904491232 scopus 로고    scopus 로고
    • Spring Valley, NY: Par Pharmaceutical Companies, Inc
    • Spring Valley, NY: Par Pharmaceutical Companies, Inc; 2013:.
    • (2013)
  • 18
    • 84904491223 scopus 로고    scopus 로고
    • Indianapolis, IN: Eli Lilly & Company
    • Indianapolis, IN: Eli Lilly & Company; 2012:.
    • (2012)
  • 19
    • 0033674519 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of duloxetine, a dual-serotonin and norepinephrine reuptake inhibitor
    • Sharma A,Goldberg MJ,Cerimele BJ.Pharmacokinetics and safety of duloxetine, a dual-serotonin and norepinephrine reuptake inhibitor.J Clin Pharmacol. 2000;40:161-167.
    • (2000) J Clin Pharmacol , vol.40 , pp. 161-167
    • Sharma, A.1    Goldberg, M.J.2    Cerimele, B.J.3
  • 20
    • 44149127089 scopus 로고    scopus 로고
    • Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors
    • Tamiya J,Dyck B,Zhang M,et al.Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.Bioorg Med Chem Lett. 2008;18:3328-3332.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 3328-3332
    • Tamiya, J.1    Dyck, B.2    Zhang, M.3
  • 21
    • 84875475046 scopus 로고    scopus 로고
    • Efficacy and safety of levomilnacipran sustained release 40 mg, 80 mg, or 120 mg in major depressive disorder: a phase 3, randomized, double-blind, placebo-controlled study
    • Asnis GM,Bose A,Gommoll CP,Chen C,Greenberg WM.Efficacy and safety of levomilnacipran sustained release 40 mg, 80 mg, or 120 mg in major depressive disorder: a phase 3, randomized, double-blind, placebo-controlled study.J Clin Psychiatry. 2013;74:242-248.
    • (2013) J Clin Psychiatry , vol.74 , pp. 242-248
    • Asnis, G.M.1    Bose, A.2    Gommoll, C.P.3    Chen, C.4    Greenberg, W.M.5
  • 22
    • 84904491224 scopus 로고    scopus 로고
    • Levomilnacipran SR 40 mg and 80 mg in major depressive disorder: a phase III, randomized, double-blind, fixed-dose, placebo-controlled study
    • Paper presented at: 51st Annual Meeting of the American College of Neuropsychopharmacology; Hollywood, FL;
    • Bakish D,Gommoll C,Chen C,et al.Levomilnacipran SR 40 mg and 80 mg in major depressive disorder: a phase III, randomized, double-blind, fixed-dose, placebo-controlled study. Paper presented at: 51st Annual Meeting of the American College of Neuropsychopharmacology; Hollywood, FL.
    • (2012)
    • Bakish, D.1    Gommoll, C.2    Chen, C.3
  • 23
    • 84904491216 scopus 로고    scopus 로고
    • Phase III, double-blind, placebo-controlled, flexible-dose study of levomilnacipran SR in patients with major depressive disorder
    • Paper presented at: 51st Annual Meeting of the American College of Neuropsychopharmacology; Hollywood, FL;
    • Sambunaris A,Bose A,Gommoll C,et al.Phase III, double-blind, placebo-controlled, flexible-dose study of levomilnacipran SR in patients with major depressive disorder. Paper presented at: 51st Annual Meeting of the American College of Neuropsychopharmacology; Hollywood, FL.
    • (2012)
    • Sambunaris, A.1    Bose, A.2    Gommoll, C.3
  • 24
    • 84881508999 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved
    • Renoir T.Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved.Front Pharmacol. 2013;4:45.
    • (2013) Front Pharmacol , vol.4 , pp. 45
    • Renoir, T.1
  • 25
    • 84886718928 scopus 로고    scopus 로고
    • Levomilnacipran for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed?
    • Citrome L.Levomilnacipran for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed?.Int J Clin Pract. 2013;67:1089-1104.
    • (2013) Int J Clin Pract , vol.67 , pp. 1089-1104
    • Citrome, L.1
  • 26
    • 36048982476 scopus 로고    scopus 로고
    • Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction
    • Ramsay RR,Dunford C,Gillman PK.Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction.Br J Pharmacol. 2007;152:946-951.
    • (2007) Br J Pharmacol , vol.152 , pp. 946-951
    • Ramsay, R.R.1    Dunford, C.2    Gillman, P.K.3
  • 29
    • 84904491217 scopus 로고    scopus 로고
    • US National Library of Medicine. Drugs and Lactation Database (LactMed). Bethesda, MD: Accessed February 26
    • US National Library of Medicine. Drugs and Lactation Database (LactMed). Bethesda, MD: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed February 26, 2014.
    • (2014)
  • 30
    • 84904471406 scopus 로고    scopus 로고
    • STEPS for cost effective prescribing of serotonin-norepinephrine reuptake inhibitors (SNRIs) in major depressive disorder: focus on venlafaxine (Effexor) versus duloxetine (Cymbalta)
    • Alipour A.STEPS for cost effective prescribing of serotonin-norepinephrine reuptake inhibitors (SNRIs) in major depressive disorder: focus on venlafaxine (Effexor) versus duloxetine (Cymbalta).Ment Health Clin. 2013;3:100.
    • (2013) Ment Health Clin , vol.3 , pp. 100
    • Alipour, A.1
  • 31
    • 84904491218 scopus 로고    scopus 로고
    • Composite list: All QT drugs Arizona Center for Education and Research on Therapeutics Accessed November 30
    • Composite list: All QT drugs Arizona Center for Education and Research on Therapeutics. http://www.crediblemeds.org/everyone/composite-list-all-qtdrugs/. Accessed November 30, 2013.
    • (2013)
  • 32
    • 84904491219 scopus 로고    scopus 로고
    • Medical Letter Online. Levomilnacipran (Feztima): a new SNRI for depression Accessed February 24
    • Medical Letter Online. Levomilnacipran (Feztima): a new SNRI for depression. http://secure.medicalletter.org/TML-article-1432a. Accessed February 24, 2014.
    • (2014)
  • 33
    • 84904491220 scopus 로고    scopus 로고
    • Levomilnacipran SR in the treatment of major depressive disorder: an analysis of efficacy data from 2 phase III studies
    • Paper presented at: 52nd Annual Meeting of the New Clinical Drug Evaluation Unit; Phoenix, AZ;
    • Bose A,Gommoll C,Li H,Ruth A,Escher T.Levomilnacipran SR in the treatment of major depressive disorder: an analysis of efficacy data from 2 phase III studies. Paper presented at: 52nd Annual Meeting of the New Clinical Drug Evaluation Unit; Phoenix, AZ.
    • (2012)
    • Bose, A.1    Gommoll, C.2    Li, H.3    Ruth, A.4    Escher, T.5
  • 34
    • 84876570587 scopus 로고    scopus 로고
    • Efficacy and safety of levomilnacipran sustained release in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled proof-of-concept study
    • Montgomery SA,Mansuy L,Ruth A,Bose A,Li H,Li D.Efficacy and safety of levomilnacipran sustained release in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled proof-of-concept study.J Clin Psychiatry. 2013;74:363-369.
    • (2013) J Clin Psychiatry , vol.74 , pp. 363-369
    • Montgomery, S.A.1    Mansuy, L.2    Ruth, A.3    Bose, A.4    Li, H.5    Li, D.6
  • 35
    • 84904491221 scopus 로고    scopus 로고
    • Levomilnacipran SR in the treatment of major depressive disorder: an analysis of safety and tolerability data from 2 randomized placebo-controlled trials
    • Paper presented at: 52nd Annual Meeting of the New Clinical Drug Evaluation Unit; Phoenix, AZ;
    • Greenberg W,Li H,Gommoll C,Ruth A,Escher T.Levomilnacipran SR in the treatment of major depressive disorder: an analysis of safety and tolerability data from 2 randomized placebo-controlled trials. Paper presented at: 52nd Annual Meeting of the New Clinical Drug Evaluation Unit; Phoenix, AZ.
    • (2012)
    • Greenberg, W.1    Li, H.2    Gommoll, C.3    Ruth, A.4    Escher, T.5
  • 36
    • 84895892250 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of the efficacy and safety of levomilnacipran ER 40-120 mg/day for prevention of relapse in patients with major depressive disorder
    • Shiovitz T,Greenberg WM,Chen C,Forero G,Gommoll CP.A randomized, double-blind, placebo-controlled trial of the efficacy and safety of levomilnacipran ER 40-120 mg/day for prevention of relapse in patients with major depressive disorder.Innov Clin Neurosci. 2014;11 (1-2): 10-22.
    • (2014) Innov Clin Neurosci , vol.11 , Issue.1-2 , pp. 10-22
    • Shiovitz, T.1    Greenberg, W.M.2    Chen, C.3    Forero, G.4    Gommoll, C.P.5
  • 37
    • 38749108920 scopus 로고    scopus 로고
    • Development and reliability of a structured interview guide for the Montgomery-Åsberg Depression Rating Scale (SIGMA)
    • Williams JB,Kobak KA.Development and reliability of a structured interview guide for the Montgomery-Åsberg Depression Rating Scale (SIGMA).Br J Psychiatry. 2008;192:52-58.
    • (2008) Br J Psychiatry , vol.192 , pp. 52-58
    • Williams, J.B.1    Kobak, K.A.2
  • 39
    • 84885110586 scopus 로고    scopus 로고
    • Safety and tolerability of levomilnacipran ER in major depressive disorder: results from an open-label, 48-week extension study
    • Mago R,Forero G,Greenberg WM,Gommoll C,Chen C.Safety and tolerability of levomilnacipran ER in major depressive disorder: results from an open-label, 48-week extension study.Clin Drug Investig. 2013;33:761-771.
    • (2013) Clin Drug Investig , vol.33 , pp. 761-771
    • Mago, R.1    Forero, G.2    Greenberg, W.M.3    Gommoll, C.4    Chen, C.5
  • 40
    • 84902196986 scopus 로고    scopus 로고
    • Efficacy of levomilnacipran extended-release in improving functional impairment associated with major depressive disorder: pooled analysis of five double-blind, placebo-controlled trials [published online March 27, 2014]
    • Accessed April 5
    • SambunarisAGommollCChenCGreenbergWM. Efficacy of levomilnacipran extended-release in improving functional impairment associated with major depressive disorder: pooled analysis of five double-blind, placebo-controlled trials [published online March 27, 2014]. Int Clin Psychopharmacol. http://journals.lww.com/intclinpsychopharm/Abstract/publishahead/Efficacy_of_levomilnacipran_extended_release_in.99749.aspx. Accessed April 5, 2014.
    • (2014) Int Clin Psychopharmacol
    • Sambunaris, A.1    Gommoll, C.2    Chen, C.3    Greenberg, W.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.