메뉴 건너뛰기




Volumn 38, Issue 6, 2014, Pages 736-743

Preliminary safety and efficacy of L-carnitine infusion for the treatment of vasopressor-dependent septic shock: A randomized control trial

Author keywords

carnitine; L carnitine; randomized control trial; sepsis; shock

Indexed keywords

ADRENALIN; CARNITINE; DOPAMINE; HEPARIN; HYPERTENSIVE FACTOR; NORADRENALIN; PHENYLEPHRINE; PLACEBO; SODIUM CHLORIDE; STEROID; VASOPRESSIN; VASOCONSTRICTOR AGENT;

EID: 84904509497     PISSN: 01486071     EISSN: 19412444     Source Type: Journal    
DOI: 10.1177/0148607113495414     Document Type: Article
Times cited : (44)

References (16)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus D, Linde-Zwirble W, Lidicker J, Clermont G, Carcillo J, Pinsky M. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 ; 29: 1303-1310 (Pubitemid 32641789)
    • (2001) Critical Care Medicine , vol.29 , Issue.7 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 2
    • 0037151571 scopus 로고    scopus 로고
    • Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    • Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002 ; 288: 862-871
    • (2002) JAMA , vol.288 , pp. 862-871
    • Annane, D.1    Sebille, V.2    Charpentier, C.3
  • 4
    • 0036892452 scopus 로고    scopus 로고
    • Bench-to-bedside review: Cytopathic hypoxia
    • DOI 10.1186/cc1824
    • Fink M. Bench-to-bedside review: cytopathic hypoxia. Crit Care. 2002 ; 6: 491-499 (Pubitemid 35414580)
    • (2002) Critical Care , vol.6 , Issue.6 , pp. 491-499
    • Fink, M.P.1
  • 5
    • 0346788905 scopus 로고    scopus 로고
    • Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis
    • Eaton S, Fukumoto K, Stefanutti G, Spitz L, Zammit VA, Pierro A. Myocardial carnitine palmitoyltransferase 1 as a target for oxidative modification in inflammation and sepsis. Biochem Soc Trans. 2003 ; 31: 1133-1136 (Pubitemid 38030924)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.6 , pp. 1133-1136
    • Eaton, S.1    Fukumoto, K.2    Stefanutti, G.3    Spitz, L.4    Zammit, V.A.5    Pierro, A.6
  • 6
    • 0030203145 scopus 로고    scopus 로고
    • Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: Effects on plasma lactate
    • Vary TC. Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: effects on plasma lactate [abstract]. Shock. 1996 ; 6: 89-94 (Pubitemid 126727745)
    • (1996) Shock , vol.6 , Issue.2 , pp. 89-94
    • Vary, T.C.1
  • 7
    • 0021808044 scopus 로고
    • Plasma carnitine levels and urinary carnitine excretion during sepsis
    • Nani G, Pittiruti M, Giovannini I, Boldrini G, Ronconi P, Castagneto M. Plasma carnitine levels and urinary carnitine excretion during sepsis. JPEN J Parenter Enteral Nutr. 1985 ; 9: 483-490 (Pubitemid 15060513)
    • (1985) Journal of Parenteral and Enteral Nutrition , vol.9 , Issue.4 , pp. 483-490
    • Nanni, G.1    Pittiruti, M.2    Giovannini, I.3
  • 8
    • 0025772754 scopus 로고
    • Influence of acetyl-L-carnitine infusion on haemodynamic parameters and survival of circulatory-shock patients
    • Gasparetto A, Corbucci GG, de Blasi RA, et al. Influence of acetyl-L-carnitine infusion on haemodynamic parameters and survival of circulatory-shock patients. Int J Clin Pharm Res. 1991 ; 11: 83-92
    • (1991) Int J Clin Pharm Res , vol.11 , pp. 83-92
    • Gasparetto, A.1    Corbucci, G.G.2    De Blasi, R.A.3
  • 11
    • 84874942100 scopus 로고    scopus 로고
    • Cumulative vasopressor index (CVI) as an assessment of cardiovascular organ dysfunction and indicator of outcome in patients with septic shock
    • Siddiqui FS, Kumar A, Woodward B, Wang Y. Cumulative vasopressor index (CVI) as an assessment of cardiovascular organ dysfunction and indicator of outcome in patients with septic shock. Crit Care Med. 2007 ; 35: A7
    • (2007) Crit Care Med , vol.35 , pp. 7
    • Siddiqui, F.S.1    Kumar, A.2    Woodward, B.3    Wang, Y.4
  • 12
    • 34548018339 scopus 로고    scopus 로고
    • Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock
    • DOI 10.1378/chest.07-0234
    • Jones AE, Focht A, Horton JM, Kline JA. Prospective external validation of the clinical effectiveness of an emergency department-based early goal directed therapy protocol for severe sepsis and septic shock. Chest. 2007 ; 132: 425-432 (Pubitemid 47282372)
    • (2007) Chest , vol.132 , Issue.2 , pp. 425-432
    • Jones, A.E.1    Focht, A.2    Horton, J.M.3    Kline, J.A.4
  • 13
    • 63249128249 scopus 로고    scopus 로고
    • Intensive versus conventional glucose control in critically ill patients
    • Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 ; 360: 1283-1297
    • (2009) N Engl J Med , vol.360 , pp. 1283-1297
  • 15
    • 84904508027 scopus 로고    scopus 로고
    • FDA clinical review drotrecogin alfa (activated) [recombinant human activated protein C (rhAPC)] Xigris
    • FDA clinical review drotrecogin alfa (activated) [recombinant human activated protein C (rhAPC)] Xigris. 2012. http://www.fda.gov/downloads/drugs/ developmentapprovalprocess/howdrugsaredevelopedandapproved/approvalapplications/ therapeuticbiologicapplications/ucm113438.pdf
    • (2012)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.