Effect of rhBMP-2 dose on bone formation/maturation in a rat critical-size calvarial defect model

Journal of Clinical Periodontology

Volumn 41, Issue 8, 2014, Pages 827-836

  Pelaez, Manuel ^a,b   Susin, Cristiano ^a   Lee, Jaebum ^a   Fiorini, Tiago ^a,c   Bisch, Frederick C ^d   Dixon, Douglas R ^b   McPherson III, James C ^e   Buxton, Amanda N ^f   Wikesjö, Ulf M E ^a  

^a AUGUSTA UNIVERSITY   (United States)

^b US Army Dental Activity Fort Gordon   (United States)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d US Army Advanced Education Program in Periodontics   (United States)

^e U S ARMY   (United States)

^f Medtronic Spine and Biologics   (United States)

Author keywords

animal models; BMP 2; bone formation; bone maturation; calvarial bone; dose

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; DRUG CARRIER; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; BIODEGRADABLE IMPLANT; BONE DENSITY; BONE DEVELOPMENT; BONE DISEASES; BONE MARROW; BONE MINERALIZATION; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; MALE; PATHOLOGY; RANDOMIZATION; RAT; SKULL; SPRAGUE DAWLEY RAT; TIME; WOUND HEALING;

ABSORBABLE IMPLANTS; ANIMALS; BONE DENSITY; BONE DISEASES; BONE MARROW; BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; MALE; OSTEOGENESIS; PARIETAL BONE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 84904460984     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/jcpe.12270     Document Type: Article

References (33)

1. Ahn, S. H., Kim, C. S., Suk, H. J., Lee, Y. J., Choi, S. H., Chai, J. K., Kim, C. K., Han, S. B., &, Cho, K. S., (2003) Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects. Journal of Periodontology 74, 787-797.
2. Bae, H. W., Strenge, K. B., Ashraf, N., Badura, J. M., Peckham, S. M., &, McKay, W. F., (2012) Transient soft-tissue edema associated with implantation of increasing doses of rhBMP-2 on an absorbable collagen sponge in an ectopic rat model. The Journal of Bone & Joint Surgery. American Volume 94, 1845-1852.
3. Bateman, J. P., Safadi, F. F., Susin, C., &, Wikesjö, U. M. E., (2012) Exploratory study on the effect of osteoactivin on bone formation in the rat critical-size calvarial defect model. Journal of Periodontal Research 47, 243-247.
4. Choi, J. Y., Jung, U. W., Kim, C. S., Eom, T. K., Kang, E. J., Cho, K. S., Kim, C. K., &, Choi, S. H., (2010) The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects. Journal of Periodontal & Implant Science 40, 11-18.
5. Choi, S. Y., Nilvéus, R. E., Minutello, R. D., Zimmerman, G. J., &, Wikesjö, U. M. E., (1993) Effect of a collagen matrix on healing in periodontal fenestration defects in dogs. Journal of Periodontology 64, 878-882.
6. de Freitas, R. M., Spin-Neto, R., Violin Dias Pereira, L. A., Marcantonio, E. Jr, Wikesjö, U. M. E., &, Susin, C,. (2013a) Alveolar ridge and maxillary sinus augmentation using rhBMP-2: systematic review. Clinical Implant Dentistry and Related Research. Doi: 10.1111/cid.12156.
7. de Freitas, R. M., Susin, C., Spin-Neto, R., Marcantonio, C., Wikesjö, U. M. E., Violin Dias Pereira, L. A., &, Marcantonio, E., Jr. (2013b) Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial. Journal of Clinical Periodontology 40, 968-975.
8. Han, D. K., Kim, C. S., Jung, U. W., Chai, J. K., Choi, S. H., Kim, C. K., &, Cho, K. S., (2005) Effect of a fibrin-fibronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects. Journal of Periodontolology 76, 2216-2222.
9. Herberg, S., Susin, C., Pelaez, M., Howie, N., Moreno de Freitas, R., Lee, J., Johnson, M. H., Elsalanty, M. E., Hamrick, M. W., Isales, C. M., Wikesjö, U. M. E., &, Hill, W. D., (2014) Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β co-therapy induces bone in critical-size rat calvarial defects. Tissue Engineering Part A 20, 1444-1453.
10. Hong, S. J., Kim, C. S., Han, D. K., Cho, I. H., Jung, U. W., Choi, S. H., Kim, C. K., &, Cho, K. S., (2006) The effect of a fibrin-fibronectin/ beta-tricalcium phosphate/ recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects. Biomaterials 27, 3810-3816.
11. Jovanovic, S. A., Hunt, D. R., Bernard, G. W., Spiekermann, H., Wozney, J. M., &, Wikesjö, U. M. E., (2007) Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clinical Oral Implants Research 18, 224-230.
12. Jung, U. W., Choi, S. Y., Pang, E. K., Kim, C. S., Choi, S. H., &, Cho, K. S., (2006) The effect of varying the particle size of beta tricalcium phosphate carrier of recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defect. Journal of Periodontology 77, 765-772.
13. Lee, J. H., Kim, C. S., Choi, K. H., Jung, U. W., Yun, J. H., Choi, S. H., &, Cho, K. S., (2010) The induction of bone formation in rat calvarial defects and subcutaneous tissues by recombinant human BMP-2, produced in Escherichia coli. Biomaterials 31, 3512-3519.
14. Leknes, K. N., Yang, J., Qahash, M., Polimeni, G., Susin, C., &, Wikesjö, U. M. E., (2008) Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: radiographic observations. Clinical Oral Implants Research 19, 1027-1033.
15. ® Bone Graft). International Orthopaedics 31, 729-734. (Pubitemid 350160311)
16. Muschler, G. F., Raut, V. P., Patterson, T. E., Wenke, J. C., &, Hollinger, J. O., (2010) The design and use of animal models for translational research in bone tissue engineering and regenerative medicine. Tissue Engineering Part B: Reviews 16, 123-145.
17. Pang, E. K., Paik, J. W., Kim, S. K., Jung, U. W., Kim, C. S., Cho, K. S., Kim, C. K., &, Choi, S. H., (2005) Effects of chitosan on human periodontal ligament fibroblasts in vitro and on bone formation in rat calvarial defects. Journal of Periodontology 76, 1526-1533.
18. Pöhling, S., Pippig, S. D., Hellerbrand, K., Siedler, M., Schütz, A., &, Dony, C., (2006) Superior effect of MD05, beta-tricalcium phosphate coated with recombinant human growth/differentiation factor-5, compared to conventional bone substitutes in the rat calvarial defect model. Journal of Periodontology 77, 1582-1590. (Pubitemid 44740769)
19. Pryor, M. E., Polimeni, G., Koo, K. T., Hartman, M. J., Gross, H., April, M., Safadi, F. F., &, Wikesjö, U. M. E., (2005a) Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: histologic and histometric observations. Journal of Clinical Periodontology 32, 966-972. (Pubitemid 41175591)
20. Pryor, M. E., Yang, J., Polimeni, G., Koo, K. T., Hartman, M. J., Gross, H., Agelan, A., Manns, J. M., &, Wikesjö, U. M. E., (2005b) Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: radiographic observations. Journal of Periodontology 76, 1287-1292. (Pubitemid 41245772)
21. Sigurdsson, T. J., Fu, E., Tatakis, D. N., Rohrer, M. D., &, Wikesjö, U. M. E., (1997) Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Clinical Oral Implants Research 8, 367-374. (Pubitemid 127688511)
22. Spicer, P. P., Kretlow, J. D., Young, S., Jansen, J. A., Kasper, F. K., &, Mikos, A. G., (2012) Evaluation of bone regeneration using the rat critical size calvarial defect. Nature Protocols 7, 1918-1929.
23. Stancoven, B. W., Lee, J., Dixon, D. R., McPherson, J. C., Bisch, F. C., Wikesjö, U. M. E., &, Susin, C., (2012) Effect of bone morphogenetic protein-2, demineralized bone matrix and systemic parathyroid hormone (1-34) on local bone formation in a rat calvaria critical-size defect model. Journal of Periodontal Research 48, 243-251.
24. Tatakis, D. N., Koh, A., Jin, L., Wozney, J. M., Rohrer, M. D., &, Wikesjö, U. M. E., (2002) Peri-implant bone regeneration using rhBMP-2/ACS in a canine model: a dose-response study. Journal of Periodontal Research 37, 93-100.
25. Urist, M. R., (1965) Bone: formation by autoinduction. Science 150, 893-899.
26. Valentin-Opran, A., Wozney, J., Csimma, C., Lilly, L., &, Reidel, G. E., (2002) Clinical evaluation of recombinant human bone morphogenetic protein-2. Clinical Orthopaedics and Related Research 395, 110-120. (Pubitemid 34136661)
27. Wikesjö, U. M. E., Huang, Y. H., Polimeni, G., &, Qahash, M., (2007) Bone morphogenetic proteins: a realistic alternative to bone grafting for alveolar reconstruction. Oral & Maxillofacial Surgery Clinics of North America 19, 535-551.
28. Wikesjö, U. M. E., Qahash, M., Polimeni, G., Susin, C., Shanaman, R. H., Rohrer, M. D., Wozney, J. M., &, Hall, J., (2008a) Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: histologic observations. Journal of Clinical Periodontology 35, 1001-1010.
29. Wikesjö, U. M. E., Qahash, M., Thomson, R. C., Cook, A. D., Rohrer, M. D., Wozney, J. M., &, Hardwick, W. R., (2003) Space-providing expanded polytetrafluoroethylene devices define alveolar augmentation at dental implants induced by recombinant human bone morphogenetic protein-2. Clinical Implant Dentistry and Related Research 5, 112-123. (Pubitemid 37158043)
30. Wikesjö, U. M. E., Qahash, M., Thomson, R. C., Cook, A. D., Rohrer, M. D., Wozney, J. M., &, Hardwick, W. R., (2004) rhBMP-2 significantly enhances guided bone regeneration. Clinical Oral Implants Research 15, 194-204. (Pubitemid 40109804)
31. Wikesjö, U. M. E., Xiropaidis, A. V., Qahash, M., Lim, W. H., Sorensen, R. G., Rohrer, M. D., Wozney, J. M., &, Hall, J., (2008b) Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior mandible (Type II bone) in dogs. Journal of Clinical Periodontology 35, 985-991.
32. Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R. W., Hewick, R. M., &, Wang, E. A., (1988) Novel regulators of bone formation: molecular clones and activities. Science 242, 1528-1534. (Pubitemid 19023695)
33. Yun, J. I., Wikesjö, U. M. E., Borke, J. L., Bisch, F. C., Lewis, J. E., Herold, R. W., Swiec, G. D., Wood, J. C., &, McPherson, J. C., (2010) Effect of systemic parathyroid hormone (1-34) and a beta-tricalcium phosphate biomaterial on local bone formation in a critical-size rat calvarial defect model. Journal of Clinical Periodontology 37, 419-426.