Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance

European Journal of Cell Biology

Volumn 93, Issue 5-6, 2014, Pages 252-266

  Gurniak, Christine B ^a   Chevessier, Frédéric ^b   Jokwitz, Melanie ^a   Jönsson, Friederike ^c   Perlas, Emerald ^d   Richter, Hendrik ^a   Matern, Gabi ^a   Boyl, Pietro Pilo ^a   Chaponnier, Christine ^e   Fürst, Dieter ^a   Schröder, Rolf ^b   Witke, Walter ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c INSTITUT PASTEUR   (France)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^e UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Actin isoform exchange; Cofilin2; Muscle development; Protein aggregate myopathy; Sarcomere structure

Indexed keywords

COFILIN 2; MUSCLE PROTEIN; ACTIN; CFL2 PROTEIN, MOUSE; PROTEIN AGGREGATE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; MOUSE; MUSCLE ATROPHY; MUSCLE DEVELOPMENT; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SARCOPLASM; SKELETAL MUSCLE; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; C57BL MOUSE; CYTOSKELETON; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART MUSCLE; KNOCKOUT MOUSE; METABOLISM; MUSCLE DISEASE; PATHOLOGY; SARCOMERE; SMOOTH MUSCLE;

MURINAE; MUS;

ACTINS; ANIMALS; BRAIN; COFILIN 2; CYTOSKELETON; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE DEVELOPMENT; MUSCLE, SKELETAL; MUSCLE, SMOOTH; MUSCULAR DISEASES; MYOCARDIUM; ORGAN SPECIFICITY; PROTEIN AGGREGATES; SARCOMERES;

EID: 84904460755     PISSN: 01719335     EISSN: 16181298     Source Type: Journal    
DOI: 10.1016/j.ejcb.2014.01.007     Document Type: Article

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