Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model

Journal of Orthopaedic Research

Volumn 32, Issue 9, 2014, Pages 1175-1180

  Akagi, Ryuichiro ^a   Sasho, Takahisa ^a   Saito, Masahiko ^a   Endo, Jun ^a   Yamaguchi, Satoshi ^a   Muramatsu, Yuta ^a   Mukoyama, Shunsuke ^a   Akatsu, Yorikazu ^a   Katsuragi, Joe ^a   Fukawa, Taisuke ^a   Takahashi, Kazuhisa ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

DMM; in vivo; MMP 13; mouse; siRNA

Indexed keywords

COLLAGENASE 3; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSFECTION; HISTOPATHOLOGY; IN VIVO STUDY; KNEE MENISCUS; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCORING SYSTEM;

DMM; IN VIVO; MMP-13; MOUSE; SIRNA;

ANIMALS; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; MALE; MATRIX METALLOPROTEINASE 13; MICE; MICE, INBRED C57BL; OSTEOARTHRITIS, KNEE; RNA, SMALL INTERFERING; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84904443950     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22654     Document Type: Article

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