-
1
-
-
0029086370
-
Prognostic factors in 1,521 melanoma patients with distant metastases
-
Barth A, Wanek LA, Morton DL. Prognostic factors in 1,521 melanoma patients with distant metastases. J Am Coll Surg 1995;181:193-201.
-
(1995)
J Am Coll Surg
, vol.181
, pp. 193-201
-
-
Barth, A.1
Wanek, L.A.2
Morton, D.L.3
-
2
-
-
40449139053
-
Immunotherapy of advanced or metastatic melanoma
-
Cebon J, Gedye C, John T, et al. Immunotherapy of advanced or metastatic melanoma. Clin Adv Hematol Oncol 2007;5:994-1006.
-
(2007)
Clin Adv Hematol Oncol
, vol.5
, pp. 994-1006
-
-
Cebon, J.1
Gedye, C.2
John, T.3
-
3
-
-
0029004990
-
Spontaneous regression of human melanoma/nonmelanoma skin cancer: Association with infiltrating CD4+ T cells
-
Halliday GM, Patel A, Hunt MJ, et al. Spontaneous regression of human melanoma/nonmelanoma skin cancer: association with infiltrating CD4+ T cells. World J Surg 1995;19:352-8.
-
(1995)
World J Surg
, vol.19
, pp. 352-358
-
-
Halliday, G.M.1
Patel, A.2
Hunt, M.J.3
-
4
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005;353:2135-47.
-
(2005)
N Engl J Med
, vol.353
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
-
5
-
-
79952601620
-
BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site
-
Bauer J, Büttner P, Murali R, et al. BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site. Pigment Cell Melanoma Res 2011;24:345-51.
-
(2011)
Pigment Cell Melanoma Res
, vol.24
, pp. 345-351
-
-
Bauer, J.1
Büttner, P.2
Murali, R.3
-
6
-
-
84978034236
-
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
-
Long GV, Menzies AM, Nagrial AM, et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol 2011;29:1239-46.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1239-1246
-
-
Long, G.V.1
Menzies, A.M.2
Nagrial, A.M.3
-
7
-
-
84864722943
-
NRAS mutation status is an independent prognostic factor in metastatic melanoma
-
Jakob JA, Bassett RL Jr, Ng CS, et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer 2012;118:4014-23.
-
(2012)
Cancer
, vol.118
, pp. 4014-4023
-
-
Jakob, J.A.1
Bassett Jr., R.L.2
Ng, C.S.3
-
8
-
-
79959195681
-
KIT pathway alterations in mucosal melanomas of the vulva and other sites
-
Omholt K, Grafström E, Kanter-Lewensohn L, et al. KIT pathway alterations in mucosal melanomas of the vulva and other sites. Clin Cancer Res 2011;17:3933-42.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3933-3942
-
-
Omholt, K.1
Grafström, E.2
Kanter-Lewensohn, L.3
-
9
-
-
79960708519
-
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
-
Guo J, Si L, Kong Y, et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol 2011;29:2904-9.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2904-2909
-
-
Guo, J.1
Si, L.2
Kong, Y.3
-
10
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-19.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
11
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
12
-
-
84865068182
-
Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (VEM) with dacarbazine (DTIC) in previously untreated pa tients with BRAFV600E-mutated melanoma
-
2012 ASCO Annual Meeting Proceedings
-
Chapman PB, Hauschild A, Robert C, et al. Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (VEM) with dacarbazine (DTIC) in previously untreated pa tients with BRAFV600E-mutated melanoma. 2012 ASCO Annual Meeting Proceedings. J Clin Oncol 2012;30(15 Suppl):8502.
-
(2012)
J Clin Oncol
, vol.30
, Issue.15 SUPPL.
, pp. 8502
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
13
-
-
84864297421
-
Phase III, randomized, open-label, multicenter trial (BREAK-3) comparing the BRAF kinase inhibitor dabrafenib (GSK2118436) with dacarbazine (DTIC) in patients with BRAFV600E-mutated melanoma
-
2012 ASCO Annual Meeting Proceedings
-
Hauschild A, Grob JJ, Demidov LV, et al. Phase III, randomized, open-label, multicenter trial (BREAK-3) comparing the BRAF kinase inhibitor dabrafenib (GSK2118436) with dacarbazine (DTIC) in patients with BRAFV600E-mutated melanoma. 2012 ASCO Annual Meeting Proceedings. J Clin Oncol 2012;30(18 Suppl): LBA8500.
-
(2012)
J Clin Oncol
, vol.30
, Issue.18 SUPPL.
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
14
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
Phan GQ, Yang JC, Sherry RM, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A 2003;100:8372-7.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
-
15
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
16
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 2009;15:7412-20.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
-
17
-
-
84877743290
-
Five-year survival rates for patients (PTS) with metastatic melanoma (MM) treated with ipilimumab (IPI) in phase II trials
-
[abstract]. Proceedings of the 2012 European Oncology Congress; 2012 Sept. 28 to Oct. 2; Vienna, Austria
-
Lebbe C, Weber JS, Maio M, et al. Five-year survival rates for patients (PTS) with metastatic melanoma (MM) treated with ipilimumab (IPI) in phase II trials [abstract]. Proceedings of the 2012 European Oncology Congress; 2012 Sept. 28 to Oct. 2; Vienna, Austria. Ann Oncol 2012;23(Suppl 9):9053.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
, pp. 9053
-
-
Lebbe, C.1
Weber, J.S.2
Maio, M.3
-
18
-
-
78650428877
-
Blockade of cytotoxic Tlymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma
-
Berman D, Parker SM, Siegel J, et al. Blockade of cytotoxic Tlymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun 2010;10:11.
-
(2010)
Cancer Immun
, vol.10
, pp. 11
-
-
Berman, D.1
Parker, S.M.2
Siegel, J.3
-
19
-
-
67650848410
-
Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immunerelated colitis
-
Minor DR, Chin K, Kashani-Sabet M. Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immunerelated colitis. Cancer Biother Radiopharm 2009;24:321-5.
-
(2009)
Cancer Biother Radiopharm
, vol.24
, pp. 321-325
-
-
Minor, D.R.1
Chin, K.2
Kashani-Sabet, M.3
-
20
-
-
69949181343
-
Treatment guidelines for the management of immune-related adverse events in patients treated with ipilimumab, an anti-CTLA4 therapy
-
abstract
-
Chin K, Ibrahim R, Berman D, et al. Treatment guidelines for the management of immune-related adverse events in patients treated with ipilimumab, an anti-CTLA4 therapy [abstract]. Ann Oncol 2008;19(Suppl 8):787.
-
(2008)
Ann Oncol
, vol.19
, Issue.SUPPL. 8
, pp. 787
-
-
Chin, K.1
Ibrahim, R.2
Berman, D.3
-
21
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson TR, Fridlyand J, Yan Y, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012;487:505-9.
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.3
-
22
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J, Vultur A, Lee JT, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 2010;18:683-95.
-
(2010)
Cancer Cell
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
-
23
-
-
80051625929
-
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
-
Wagle N, Emery C, Berger MF, et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol 2011;29:3085-96.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3085-3096
-
-
Wagle, N.1
Emery, C.2
Berger, M.F.3
-
24
-
-
84877093633
-
Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control
-
MDX010-20 investigators
-
Robert C, Schadendorf D, Messina M, et al.; MDX010-20 investigators. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin Cancer Res 2013;19:2232-9.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2232-2239
-
-
Robert, C.1
Schadendorf, D.2
Messina, M.3
-
25
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367:1694-703.
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
-
26
-
-
66349098469
-
Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors
-
Jaiswal BS, Janakiraman V, Kljavin NM, et al. Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors. PLoS ONE 2009;4:e5717.
-
(2009)
PLoS ONE
, vol.4
-
-
Jaiswal, B.S.1
Janakiraman, V.2
Kljavin, N.M.3
-
27
-
-
84864277515
-
Efficacy and safety of oral MEK162 in patients with locally advanced and un resectable or metastatic cutaneous melanoma harboring BRAFV600 or NRAS mutations
-
2012 ASCO Annual Meeting Proceedings
-
Ascierto PA, Berking C, Agarwala SS, et al. Efficacy and safety of oral MEK162 in patients with locally advanced and un resectable or metastatic cutaneous melanoma harboring BRAFV600 or NRAS mutations. 2012 ASCO Annual Meeting Proceedings. J Clin Oncol 2012;30(15 Suppl):8511.
-
(2012)
J Clin Oncol
, vol.30
, Issue.15 SUPPL.
, pp. 8511
-
-
Ascierto, P.A.1
Berking, C.2
Agarwala, S.S.3
-
28
-
-
84879715898
-
Phase II study of selumetinib (sel) versus temozolomide (TMZ) in gnaq/Gna11 (Gq/11) mutant (mut) uveal melanoma (UM)
-
2013 ASCO Annual Meeting Proceedings
-
Richard D, Carvajal JAS, Fernando Quevedo, et al. Phase II study of selumetinib (sel) versus temozolomide (TMZ) in gnaq/Gna11 (Gq/11) mutant (mut) uveal melanoma (UM). 2013 ASCO Annual Meeting Proceedings. J Clin Oncol 2013;31(18 Suppl):CRA9003.
-
(2013)
J Clin Oncol
, vol.31
, Issue.18 SUPPL.
-
-
Richard, D.1
Carvajal, J.A.S.2
Quevedo, F.3
-
29
-
-
79955373860
-
Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells
-
Butler MO, Friedlander P, Milstein MI, et al. Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells. Sci Transl Med 2011;3:80ra34.
-
(2011)
Sci Transl Med
, vol.3
-
-
Butler, M.O.1
Friedlander, P.2
Milstein, M.I.3
-
30
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013;368:1509-18.
-
(2013)
N Engl J Med
, vol.368
, pp. 1509-1518
-
-
Grupp, S.A.1
Kalos, M.2
Barrett, D.3
-
31
-
-
55949125601
-
Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
-
Dudley ME, Yang JC, Sherry R, et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol 2008;26:5233-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5233-5239
-
-
Dudley, M.E.1
Yang, J.C.2
Sherry, R.3
-
32
-
-
84883472041
-
Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: Intent-to-treat analysis and efficacy after failure to prior immunotherapies
-
Besser MJ, Shapira-Frommer R, Itzhaki O, et al. Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies. Clin Cancer Res 2013;19:4792-800.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4792-4800
-
-
Besser, M.J.1
Shapira-Frommer, R.2
Itzhaki, O.3
-
33
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:793-800.
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
34
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010;28:3167-75.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
35
-
-
84862903106
-
Safety and activity of Anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQM, et al. Safety and activity of Anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-65.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.M.3
-
36
-
-
84865097403
-
Clinical activity and safety of anti-PD-1 (BMS-936558, MDX-1106) in patients with advanced melanoma (MEL)
-
2012 ASCO Annual Meeting Proceedings
-
Hodi FS, Sznol M, McDermott DF, et al. Clinical activity and safety of anti-PD-1 (BMS-936558, MDX-1106) in patients with advanced melanoma (MEL). 2012 ASCO Annual Meeting Proceedings. J Clin Oncol 2012;30(15 Suppl):8507.
-
(2012)
J Clin Oncol
, vol.30
, Issue.15 SUPPL.
, pp. 8507
-
-
Hodi, F.S.1
Sznol, M.2
McDermott, D.F.3
-
37
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
38
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
-
(2013)
N Engl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
-
39
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013;369:122-33.
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
40
-
-
84875785905
-
Hepatotoxicity with combination of vemurafenib and ipilimumab
-
Ribas A, Hodi FS, Callahan M, et al. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med 2013;368:1365-6.
-
(2013)
N Engl J Med
, vol.368
, pp. 1365-1366
-
-
Ribas, A.1
Hodi, F.S.2
Callahan, M.3
|