Corneal nerve alterations in different stages of Fuchs' endothelial corneal dystrophy: An in vivo confocal microscopy study

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 252, Issue 7, 2014, Pages 1119-1126

  Bucher, Franziska ^a   Adler, Werner ^b   Lehmann, Helmar C ^a   Hos, Deniz ^a   Steven, Philipp ^a   Cursiefen, Claus ^a   Heindl, Ludwig M ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Cornea; Corneal nerves; Fuchs' endothelial corneal dystrophy; In vivo confocal microscopy

Indexed keywords

ADULT; AGED; ARTICLE; CENTRAL CORNEAL THICKNESS; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONFOCAL MICROSCOPE; CONFOCAL MICROSCOPY; CONGENITAL CORNEA DYSTROPHY; CORNEA; CORNEA NERVE; DISEASE COURSE; FEMALE; HUMAN; MALE; NERVE; PRIORITY JOURNAL; SLIT LAMP; VERY ELDERLY; VISUAL ACUITY; CLASSIFICATION; CRANIAL NERVE DISEASES; FUCHS' ENDOTHELIAL DYSTROPHY; INNERVATION; MIDDLE AGED; NERVE CELL NETWORK; NERVE FIBER; OPHTHALMIC NERVE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; SENSATION;

ADULT; AGED; AGED, 80 AND OVER; CORNEA; CRANIAL NERVE DISEASES; FEMALE; FUCHS' ENDOTHELIAL DYSTROPHY; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; NERVE FIBERS; NERVE NET; OPHTHALMIC NERVE; PROSPECTIVE STUDIES; SENSATION;

EID: 84904332372     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-014-2678-3     Document Type: Article

References (29)

1. Adamis AP, Filatov V, Tripathi BJ, Tripathi RC (1993) Fuchs' endothelial dystrophy of the cornea. Surv Ophthalmol 38:149-168 (Pubitemid 23297229)
2. Matthaei M, Hu J, Meng H, Lackner EM, Eberhart CG, Qian J, Hao H, Jun AS (2013) Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 54:1931-1940
3. Matthaei M, Lackner EM, Meng H, Hicks JL, Meeker AK, Eberhart CG, Jun AS (2013) Tissue microarray analysis of cyclin-dependent kinase inhibitors p21 and p16 in Fuchs dystrophy. Cornea 32:473-478
4. Melles GR, Ong TS, Ververs B, van der Wees J (2006) Descemet membrane endothelial keratoplasty (DMEK). Cornea 25:987-990 (Pubitemid 44763867)
5. Heindl LM, Hofmann-Rummelt C, Schlötzer-Schrehardt U, Kruse FE, Cursiefen C (2008) Histologic analysis of descemet stripping in posterior lamellar keratoplasty. Arch Ophthalmol 126:461-464 (Pubitemid 351549835)
6. Heindl LM, Riss S, Bachmann BO, Laaser K, Kruse FE, Cursiefen C (2011) Split cornea transplantation for 2 recipients: a new strategy to reduce corneal tissue cost and shortage. Ophthalmology 118:294-301
7. Guerra FP, Anshu A, Price MO, Giebel AW, Price FW (2011) Descemet's membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology 118:2368-2373
8. Heindl LM, Riss S, Laaser K, Bachmann BO, Kruse FE, Cursiefen C (2011) Split cornea transplantation for 2 recipients - review of the first 100 consecutive patients. Am J Ophthalmol 152:523-532
9. Terry MA, Straiko MD, Goshe JM, Li JY, Davis-Boozer D (2012) Descemet's stripping automated endothelial keratoplasty: the tenuous relationship between donor thickness and postoperative vision. Ophthalmology 119:1988-1996
10. Heindl LM, Riss S, Adler W, Bucher F, Hos D, Cursiefen C (2013) Split cornea transplantation: relationship between storage time of split donor tissue and outcome. Ophthalmology 120:899-907
11. Cursiefen C, Kuchle M, Naumann GO (1998) Changing indications for penetrating keratoplasty: histopathology of 1,250 corneal buttons. Cornea 17:468-470 (Pubitemid 28420676)
12. Oliveira-Soto L, Efron N (2001) Morphology of corneal nerves using confocal microscopy. Cornea 20:374-384 (Pubitemid 32381817)
13. Guthoff RF, Wienss H, Hahnel C, Wree A (2005) Epithelial innervation of human cornea: a three-dimensional study using confocal laser scanning fluorescence microscopy. Cornea 24:608-613 (Pubitemid 40885043)
14. Hamrah P, Cruzat A, Dastjerdi MH, Zheng L, Shahatit BM, Bayhan HA, Dana R, Pavan-Langston D (2010) Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study. Ophthalmology 117:1930-1936
15. Hamrah P, Cruzat A, Dastjerdi MH, Prüss H, Zheng L, Shahatit BM, Bayhan HA, Dana R, Pavan-Langston D (2013) Unilateral herpes zoster ophthalmicus results in bilateral corneal nerve alteration: an in vivo confocal microscopy study. Ophthalmology 120:40-47
16. Patel DV, McGhee CN (2009) In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: a review. Br J Ophthalmol 93:853-860
17. Cruzat A, Pavan-Langston D, Hamrah P (2010) In vivo confocal microscopy of corneal nerves: analysis and clinical correlation. Semin Ophthalmol 25:171-177
18. Alhatem A, Cavalcanti B, Hamrah P (2012) In vivo confocal microscopy in dry eye disease and related conditions. Semin Ophthalmol 27:138-148
19. Kurbanyan K, Hoesl LM, Schrems WA, Hamrah P (2012) Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study. Eye 26:126-132
20. Schrems-Hoesl LM, Schrems WA, Cruzat A, Shahatit BM, Bayhan HA, Jurkunas UV, Hamrah P (2013) Cellular and sub-basal nerve alterations in early stage Fuchs' endothelial corneal dystrophy: an in vivo confocal microscopy study. Eye 27:42-49
21. Meijering E, Jacob M, Sarria JC, Steiner P, Hirling H, Unser M (2004) Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry A 58:167-176 (Pubitemid 38509178)
22. Chiou AG, Kaufman SC, Beuerman RW, Ohta T, Soliman H, Kaufman HE (1999) Confocal microscopy in cornea guttata and Fuchs' endothelial dystrophy. Br J Ophthalmol 83:185-189 (Pubitemid 29106087)
23. Mustonen RK, McDonald MB, Srivannaboon S, Tan AL, Doubrava MW, Kim CK (1998) In vivo confocal microscopy of Fuchs' endothelial dystrophy. Cornea 17:493-503 (Pubitemid 28420680)
24. Hara M, Morishige N, Chikama T, Nishida T (2003) Comparison of confocal biomicroscopy and noncontact specular microscopy for evaluation of the corneal endothelium. Cornea 22:512-515 (Pubitemid 36909728)
25. Koh SW, Waschek JA (2000) Corneal endothelial cell survival in organ cultures under oxidative stress: effect of VIP. Invest Ophthalmol Vis Sci 41:4085-4092
26. Koh SW, Chandrasekara K, Abbondandolo CJ, Coll TJ, Rutzen AR (2008) VIP and VIP gene silencing modulation of differentiation marker N-cadherin and cell shape of corneal endothelium in human corneas ex vivo. Invest Ophthalmol Vis Sci 49:3491-3498
27. Sornelli F, Lambiase A, Mantelli F, Aloe L (2010) NGF and NGF-receptor expression of cultured immortalized human corneal endothelial cells. Molecular vision 16:1439-1447
28. Zhu AY, Eberhart CG, Jun AS (2014) Fuchs endothelial corneal dystrophy: a neurodegenerative disorder? JAMA Ophthalmol 2013:7993
29. Cursiefen C, Seitz B, Kruse FE (2005) Neurotrophic keratitis. Ophthalmologe 102:7-14