Integrating molecular diagnostics into histopathology training: The Belfast model

Journal of Clinical Pathology

Volumn 67, Issue 7, 2014, Pages 632-636

  Flynn, C ^a   James, Jacqueline ^a,b   Maxwell, P ^a,b   McQuaid, S ^a,b   Ervine, A ^a   Catherwood, M ^a   Loughrey, M B ^a   McGibben, D ^a   Somerville, J ^a   McManus, D T ^a   Gray, M ^a   Herron, B ^a   Salto Tellez, Manuel ^a,b  

^a ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CURRICULUM; HISTOPATHOLOGY; MEDICAL EDUCATION; MEDICAL SPECIALIST; MODEL; MOLECULAR DIAGNOSIS; MOLECULAR PATHOLOGY; PATHOGENESIS; PATIENT CARE; PRIORITY JOURNAL; REVIEW; SOLID TUMOR;

EDUCATION; HISTOPATHOLOGY; MOLECULAR PATHOLOGY;

CLINICAL COMPETENCE; CURRICULUM; DIFFUSION OF INNOVATION; EDUCATION, MEDICAL; HUMANS; MODELS, EDUCATIONAL; NORTHERN IRELAND; PATHOLOGY; PATHOLOGY, MOLECULAR; PREDICTIVE VALUE OF TESTS; TEACHING;

EID: 84904319375     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2014-202176     Document Type: Review

References (39)

1. Catherwood MA, Schmitt F, Salto-Tellez M. Molecular diagnostics and the training of future tissue- and cell-based pathologists. Cytopathology 2012;23:283-5.
2. Jones D, Fletcher CD. How shall we apply the new biology to diagnostics in surgical pathology? J Pathol 1999;187:147-54. (Pubitemid 29009844)
3. Ross J, Ginsburg G. The integration of molecular diagnostics with therapeutics, implications for drug development and pathology practice. Am J Clin Pathol 2003;119:26-36. (Pubitemid 37047893)
4. Salto-Tellez M, Koay ESC. Molecular diagnostic cytopathology - definitions, scope and clinical utility. Cytopath 2004;15:252-5. (Pubitemid 39389257)
5. Giordano T. Molecular profiling and personalized predictive pathology: challenge to the academic surgical pathology community. Am J Surg Pathol 2006;30:402-4. (Pubitemid 43740174)
6. Dietel M, Sers C. Personalized medicine and development of targeted therapies: the upcoming challenge for diagnostic molecular pathology. A review. Virchows Arch 2006;448:744-55. (Pubitemid 43824431)
7. Friedman B. A survey of the myriad forces changing anatomic pathology and their consequences. Arch Pathol Lab Med 2008;132:735-8. (Pubitemid 351632844)
8. Lauwers G, Black-Schaffer S, Salto-Tellez M. Molecular pathology in contemporary diagnostic pathology laboratory: an opinion for the active role of surgical pathologists. Am J Surg Pathol 2010;34:115-17.
9. Aparicio S, Huntsman DG. Does massively parallel DNA resequencing signify the end of histopathology as we know it? J Pathol 2010;220:307-15.
10. Trent R. Pathology practice and pharmacogenomics. Pharmacogenomics 2010;11:105-11.
11. Schmitt F. Demystifying molecular cytopathology. Int J Surg Pathol 2010;18:213S-15S.
12. van Krieken JH, Ligtenberg M, Groenen P. Molecular pathology in contemporary diagnostic pathology laboratory. Am J Surg Pathol 2010;34:e14.
13. Teruya-Feldstein J. The immunohistochemistry laboratory looking at molecules and preparing for tomorrow. Arch Pathol Lab Med 2010;34:1659-69.
14. Tonellato P, Crawford J, Boguski M, et al. A national agenda for the future of pathology in personalized medicine. Report of the proceedings of a meeting at the banbury conference center on genome-era pathology, precision diagnostics, and preemptive care: A stakeholder summit. Am J Clin Pathol 2011;135:668-72.
15. Ross J. Next-generation pathology. Am J Clin Pathol 2011;135:663-5.
16. Su Z, Ning B, Fang H, et al. Next-generation sequencing and its applications in molecular diagnostics. Expert Rev Mol Diagn 2011;11:333-43.
17. Wall DP, Tonellato PJ. The future of genomics in pathology. F1000 Medicine Reports 2012;4:14-8.
18. Moch H, Blank PR, Dietel M, et al. Personalized cancer medicine and the future of pathology. Virchows Arch 2012;460:3-8.
19. Ziai J, Smith B. Pathology resident and fellow education in a time of disruptive technologies. Clin Lab Med 2012;32:623-38.
20. Shibata T. Cancer genomics and pathology: all together now. Pathol Int 2012;62:647-59.
21. Walk E. Pathologists in the era of personalized medicine. Arch Pathol Lab Med 2009;133:605-10.
22. Gown A, Asa S. Conclusion. Modern Pathology 2001;14:261-2. (Pubitemid 32246834)
23. Salto-Tellez M. A case for integrated morphomolecular diagnostic pathologists. Clin Chem 2007;53:1188-9.
24. Brown R. Morphogenomics and morphoproteomics: a role for anatomic pathology in personalized medicine. Arch Pathol Lab Med 2009;133:568-79.
25. Tomlin S, Robinson D, Penny R, et al. Twenty-first century pathology sign-Out. Clin Lab Med 2012;32:639-50.
26. Hutchins GGA, Grabsch HI. Molecular pathology - the future? Surgeon 2009;7:366-77.
27. Chan J, Salto-Tellez M. Opinion: molecular gestalt and modern pathology. Adv Anat Pathol 2012;19:425-6.
28. Crawford J, Tykocinski M. Pathology as the enabler of human research. Laboratory Investigation 2005;85:1058-64. (Pubitemid 43073980)
29. Perl D. The role of the pathologist in translational and personalized medicine. Mt Sinai J Med 2007;74:22-6. (Pubitemid 46957752)
30. Costa J. Systems Approach to the Practice of Pathology: A New Role for the Pathologist. Arch Pathol Lab Med 2009;133:524-6.
31. Berman D, Bosenberg M, Orwant R, et al. Investigative pathology: leading the post-genomic revolution. Lab Invest 2012;92:4-8.
32. Rodriguez-Canales J, Eberle F, Jaffe E, et al. Why is it crucial to reintegrate pathology into cancer research? Bioessays 2011;33:490-8.
33. Boyd C, Boyle DP. Molecular diagnosis on tissues and cells: how it affects training and will affect practice in the future. Cytopath 2012;23:286-94.
34. Wells A, Smith B, Sacks D. The challenge of training pathologists in the 21st century. Hum Pathol 2006;37:932-3. (Pubitemid 44080814)
35. Otis C. Residency training in anatomic pathology: looking forward in the 21st century. Hum Pathol 2006;37:929-31. (Pubitemid 44080813)
36. Association for Molecular Pathology Whole Genome Analysis Working Group. Guest Editorial: The association for molecular pathology's approach to supporting a global agenda to embrace personalized genomic medicine. J Mol Diag 2011;13:249-51.
37. Cagle P, Dacic S, Allen T. Genomic pathology challenges for implementation. Arch Pathol Lab Med 2011;135:967-8.
38. Curriculum for specialty training in histopathology: joint committee on pathology training. Unique document number G051. 2010. http://www.rcpath.org/NR/ rdonlyres/C95ED057-1C10-45F7-94FC-C16E2DADCBB2/0/histopathology-curriculum-ar. pdf [accessed 12 Nov 2013].
39. Furness P. The future of cellular pathology: the next 50 years. Bull Royal Coll Pathol 2012;160:222-6.