Exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non-smokers

Environment International

Volumn 71, Issue , 2014, Pages 139-147

  Ramírez, Noelia ^a   Özel, Mustafa Z ^a   Lewis, Alastair C ^a   Marcé, Rosa M ^b   Borrull, Francesc ^b   Hamilton, Jacqueline F ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITAT ROVIRA I VIRGILI   (Spain)

Author keywords

Cancer risk assessment; N nitrosamines; Thirdhand tobacco smoke; Tobacco specific nitrosamines (TSNAs)

Indexed keywords

DISEASES; DUST; NITROSAMINES; RISK ASSESSMENT; SMOKE; TOBACCO;

ANALYTICAL APPROACH; CANCER RISK ASSESSMENTS; DERMAL EXPOSURE; N-NITROSAMINES; POTENTIAL HEALTH RISKS; PUBLIC HEALTH POLICIES; TOBACCO SMOKE; TOBACCO SPECIFIC NITROSAMINES;

HEALTH RISKS;

1 NITROSOPIPERIDINE; 4 (METHYLNITROSOAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 4 (METHYLNITROSOAMINO) 1 (3 PYRIDYL) 1 BUTANONE; DIBUTYLNITROSAMINE; DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; DIPROPYLNITROSAMINE; ETHYLMETHYLNITROSAMINE; N NITROSOPYRROLIDINE; N' NITROSOANABASINE; N' NITROSOANATABINE; NICOTINE; NITROSAMINE; NITROSOMORPHOLINE; NITROSONORNICOTINE; TOBACCO SMOKE; UNCLASSIFIED DRUG;

CANCER; HEALTH POLICY; HEALTH RISK; PUBLIC HEALTH; RISK ASSESSMENT; SMOKE; SMOKING; TOBACCO;

AGE DISTRIBUTION; ARTICLE; CANCER RISK; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; HEALTH HAZARD; HOUSE DUST; HUMAN; PASSIVE SMOKING; PRIORITY JOURNAL; RISK ASSESSMENT;

CANCER RISK ASSESSMENT; N-NITROSAMINES; THIRDHAND TOBACCO SMOKE; TOBACCO-SPECIFIC NITROSAMINES (TSNAS);

AGE FACTORS; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, GAS; DUST; FEMALE; HUMANS; LINEAR MODELS; MALE; MOLECULAR STRUCTURE; NEOPLASMS; NITROSAMINES; RISK ASSESSMENT; SMOKING; TOBACCO; TOBACCO SMOKE POLLUTION;

EID: 84904294323     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2014.06.012     Document Type: Article

References (38)

1. Cook D.G., Strachan D.P. Summary of effects of parental smoking on the respiratory health of children and implications for research. Thorax 1999, 54:357-365.
2. Drehmer J.E., Ossip D.J., Rigotti N.A., Nabi-Burza E., Woo H., Wasserman R.C., et al. Pediatrician interventions and thirdhand smoke beliefs of parents. Am J Prev Med 2012, 43:533-536.
3. Hang B., Sarker A.H., Havel C., Saha S., Hazra T.K., Schick S., et al. Thirdhand smoke causes DNA damage in human cells. Mutagenesis 2013, 28:381-391.
4. Hecht S.S. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003, 3:733-744.
5. Hecht S.S. Progress and challenges in selected areas of tobacco carcinogenesis. Chem Res Toxicol 2008, 21:160-171.
6. Hecht S.S., Hoffmann D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco-smoke. Carcinogenesis 1988, 9:875-884.
7. Hein H.O., Suadicani P., Skov P., Gyntelberg F. Indoor dust exposure - an unnoticed aspect of involuntary smoking. Arch Environ Health 1991, 46:98-101.
8. Hoh E., Hunt R.N., Quintana P.J.E., Zakarian J.M., Chatfield D.A., Wittry B.C., et al. Environmental tobacco smoke as a source of polycyclic aromatic hydrocarbons in settled household dust. Environ Sci Technol 2012, 46:4174-4183.
9. IARC (International Agency for Research on Cancer) IARC monographs on the evaluation of the carcinogenic risks to humans - tobacco smoke and involuntary smoking, vol. 83 Available:, [accessed: 8 May 2013]. http://monographs.iarc.fr/ENG/Monographs/vol83/volume83.pdf.
10. IARC (International Agency for Research on Cancer) IARC monographs on the evaluation of the carcinogenic risks to humans - smokeless tobacco and some tobacco-specific N-nitrosamines, vol. 89 2007, WHO, Lyon, France, [Available: http://monographs.iarc.fr/ENG/Monographs/vol89/[accessed: 22 July 2013]].
11. IARC (International Agency for Research on Cancer) List of classifications by alphabetical order Available:, [accessed: 8 September 2013]. http://monographs.iarc.fr/ENG/Classification/ClassificationsAlphaOrder.pdf.
12. INE (National Institute of Statistics, Spanish Government) Available:, [accessed: 30 July 2013]. http://www.ine.es/jaxi/tabla.do?path=/t25/p442/e01/l0/&file=02006.px&type=pcaxis.
13. IRIS (Integrated Risk Information System) Available:, [accessed: 20 April 2013]. http://www.epa.gov/iris/index.html.
14. Kim S., Aung T., Berkeley E., Diette G.B., Breysse P.N. Measurement of nicotine in household dust. Environ Res 2008, 108:289-293.
15. Mahanama K.R.R., Daisey J.M. Volatile n-nitrosamines in environmental tobacco smoke: sampling, analysis, emission factors, and indoor air exposures. Environ Sci Technol 1996, 30:1477-1484.
16. Matt G.E., Quintana P.J.E., Hovell M.F., Bernert J.T., Song S., Novianti N., et al. Households contaminated by environmental tobacco smoke: sources of infant exposures. Tob Control 2004, 13:29-37.
17. Matt G.E., Quintana P.J.E., Destaillats H., Gundel L.A., Sleiman M., Singer B.C., et al. Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda. Environ Health Perspect 2011, 119:1218-1226.
18. Matt G.E., Quintana P.J.E., Zakarian J.M., Fortmann A.L., Chatfield D.A., Hoh E., et al. When smokers move out and non-smokers move in: residential thirdhand smoke pollution and exposure. Tob Control 2011, 20:1-8.
19. Mercier F., Glorennec P., Thomas O., Le Bot B. Organic contamination of settled house dust, a review for exposure assessment purposes. Environ Sci Technol 2011, 45:6716-6727.
20. Oberg M., Jaakkola M.S., Woodward A., Peruga A., Pruss-Ustun A. Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries. Lancet 2011, 377:139-146.
21. OEHHA (California Office of Environmental Health Hazard Assessment) OEHHA Toxicity Criteria Database [accessed: 28 June 2013]. http://oehha.ca.gov/risk/ChemicalDB/index.asp.
22. Ott W., Steinemann A.C., Wallace L.A. Exposure analysis 2007, CRC Press, Boca Raton, CA.
23. Ramírez N., Özel M.Z., Lewis A.C., Marcé R.M., Borrull F., Hamilton J.F. Determination of nicotine and n-nitrosamines in house dust by pressurized liquid extraction and comprehensive gas chromatography-nitrogen chemiluminiscence detection. J Chromatogr A 2012, 1219:180-187.
24. Rumchev K., Jamrozik K., Stick S., Spickett J. How free of tobacco smoke are 'smoke-free' homes?. Indoor Air 2008, 18:202-208.
25. Schick S.F., Glantz S. Concentrations of the carcinogen 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research. Cancer Epidemiol Biomarkers Prev 2007, 16:1547-1553.
26. Singer B.C., Hodgson A.T., Nazaroff W.W. Gas-phase organics in environmental tobacco smoke: 2. Exposure-relevant emission factors and indirect exposures from habitual smoking. Atmos Environ 2003, 37:5551-5561.
27. Sleiman M., Gundel L.A., Pankow J.F., Jacob P., Singer B.C., Destaillats H. Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards. Proc Natl Acad Sci U S A 2010, 107:6576-6581.
28. Sterner O. Chemistry, health and environment 2010, Wiley-VCH, Weinheim, Germany.
29. U.S.EPA (U.S.Environmental Protection Agency) Assigning values to non detected/non-quantified pesticide residues in human health food exposure assessments 2000, U.S.EPA, Washington, DC, [Available: http://www.epa.gov/oppfead1/trac/science/trac3b012.pdf [accessed: 19 February 2013]].
30. U.S.EPA (U.S.Environmental Protection Agency) Risk assessment guidance for superfund volume I: human health evaluation manual 2004, U.S.EPA, Washington, DC, [Available: http://www.epa.gov/oswer/riskassessment/ragsd/tara.htm [accessed: 20 April 2013]].
31. U.S.EPA (U.S.Environmental Protection Agency) Guidelines for carcinogen risk assessment 2005, EPA/630/P-03/00F, U.S.EPA, DC, [Available: http://www.epa.gov/cancerguidelines/[accessed: 31 July 2013]].
32. U.S.EPA (U.S.Environmental Protection Agency) U.S. Dermal exposure assessment: a summary of EPA approaches 2007, 600/R-07/040F, U.S.EPA, Washington, DC, [Available: http://cfpub.epa.gov/ncea/cfm/r ecordisplay.cfm?deid=183584 [accessed 20 March 2013]].
33. U.S.EPA (U.S.Environmental Protection Agency) Child-specific exposure factors handbook 2008, EPA/600/R-06/096F, U.S.EPA, Washington, DC, [Available: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=199243# Download [accessed 20 April 2013]].
34. U.S.EPA (U.S.Environmental Protection Agency) Exposure factors handbook 2011, U.S.EPA, Office of Research and Development, Washington, DC, [Available: http://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=236252 [accessed 30 August 2013]].
35. WHO (World Health Organization) Protection from exposure to second-hand tobacco smoke. Policy recommendations Geneva, Switzerland. Available:, [accessed 17 September 2013]. http://whqlibdoc.who.int/publications/2007/9789241563413_eng.pdf.
36. WHO (World Health Organization) 2010 Global progress report on implementation of the WHO framework convention on tobacco control Geneva, Switzerland. Available:, [accessed 5 May 2013]. http://www.who.int/fctc/reporting/progress_report_final.pdf.
37. WHO (World Health Organization) Guidelines for drinking-water quality 2011, [Geneva, Switzerland. Available: http://whqlibdoc.who.int/publications/2011/9789241548151_eng.pdf [accessed 6 March 2013]]. 4th ed.
38. Winickoff J.P., Friebely J., Tanski S.E., Sherrod C., Matt G.E., Hovell M.F., et al. Beliefs about the health effects of "thirdhand" smoke and home smoking bans. Pediatrics 2009, 123:E74-E79.