Immunolocalization of MMP-2 and MMP-9 in human rheumatoid synovium

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 6, 2014, Pages 3048-3056

  Zhou, Meng ^a   Qin, Si ^a   Chu, Yang ^a   Wang, Fengming ^b   Chen, Lujun ^a   Lu, Yahua ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Confocal scanning; Matrix metalloproteinase 2; Matrix metalloproteinase 9; Rheumatoid arthritis

Indexed keywords

GELATINASE A; GELATINASE B; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN;

BIOSYNTHESIS; CONFOCAL MICROSCOPY; ENDOTHELIUM CELL; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; IMMUNOHISTOCHEMISTRY; KNEE; MACROPHAGE; MONOCYTE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; RHEUMATOID ARTHRITIS; SYNOVIUM;

ARTHRITIS, RHEUMATOID; ENDOTHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; KNEE JOINT; MACROPHAGES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICROSCOPY, CONFOCAL; MONOCYTES; NEOVASCULARIZATION, PATHOLOGIC; SYNOVIAL MEMBRANE;

EID: 84904290231     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Harris ED Jr. Rheumatoid arthritis. Pathophysiology and implications for therapy. New Engl J Med 1990; 322: 1277-1289.
2. Lee DM and Weinblatt ME. Rheumatoid arthritis. Lancet 2001; 358: 903-11.
3. Schett G and Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol 2012; 8: 656-6564.
4. Crotti TN, Dharmapatni AA, Alias E, Zannettino AC, Smith MD and Haynes DR. The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Res Ther 2012; 14: R245.
5. Kong X, Zhang Y, Liu C, Guo W, Li X, Su X, Wan H, Sun Y and Lin N. Anti-angiogenic effect of triptolide in rheumatoid arthritis by targeting angiogenic cascade. PLoS One 2013; 8: e77513.
6. Chen L, Lu Y, Chu Y, Xie J, Ding W and Wang F. Tissue factor expression in rheumatoid synovium: a potential role in pannus invasion of rheumatoid arthritis. Acta Histochem 2013; 115: 692-697.
7. Murphy G, Knauper V, Atkinson S, Butler G, English W, Hutton M, Stracke J and Clark I. Matrix metalloproteinases in arthritic disease. Arthritis Res 2002; 4 Suppl 3: S39-S49.
8. Kerkela E, Ala-Aho R, Jeskanen L, Rechardt O, Grenman R, Shapiro SD, Kahari VM and Saarialho-Kere U. Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer. J Invest Dermatol 2000; 114: 1113-1119.
9. Chen L, Di D, Luo G, Zheng L, Tan Y, Zhang X and Xu N. Immunochemical staining of MT2-MMP correlates positively to angiogenesis of human esophageal cancer. Anticancer Res 2010; 30: 4363-4368.
10. Korpi JT, Hagstrom J, Lehtonen N, Parkkinen J, Sorsa T, Salo T and Laitinen M. Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. Surg Oncol 2011; 20: e18-e22.
11. de Rooy DP, Zhernakova A, Tsonaka R, Willemze A, Kurreeman BA, Trynka G, van Toorn L, Toes RE, Huizinga TW, Houwing-Duistermaat JJ, Gregersen PK and van der Helm-van Mil AH. A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis. Ann Rheumatic Dis 2014; 73: 1163-1169.
12. Houseman M, Potter C, Marshall N, Lakey R, Cawston T, Griffiths I, Young-Min S and Isaacs JD. Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Arthritis Res Ther 2012; 14: R30.
13. Mahmoud RK, El-Ansary AK, El-Eishi HH, Kamal HM and El-Saeed NH. Matrix metalloproteinases MMP-3 and MMP-1 levels in sera and synovial fluids in patients with rheumatoid arthritis and osteoarthritis. Italian J Biochem 2005; 54: 248-257.
14. Zeisel MB, Druet VA, Wachsmann D and Sibilia J. MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin alpha5beta1. Arthritis Res Ther 2005; 7: R118-R126.
15. Mattey DL, Nixon NB and Dawes PT. Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. Arthritis Res Ther 2012; 14: R204.
16. Chakrabarti S and Patel KD. Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res 2005; 31: 599-621.
17. Furuzawa-Carballeda J, Macip-Rodriguez PM and Cabral AR. Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. Clin Exp Rheumatol 2008; 26: 554-560.
18. Lee A, Park K, Choi SJ, Seo DH, Kim K, Kim HS, Kwon IC, Choi K, Youn SY and Youn I. Prediction of anti-arthritic drug efficacies by monitoring active matrix metalloproteinase-3 (MMP-3) levels in collagen-induced arthritic mice using the MMP-3 probe. Mol Pharm 2014; 11: 1450-1458.
19. Antipova O and Orgel JP. Non-enzymatic decomposition of collagen fibers by a biglycan antibody and a plausible mechanism for rheumatoid arthritis. PLoS One 2012; 7: e32241.
20. Chang YH, Lin IL, Tsay GJ, Yang SC, Yang TP, Ho KT, Hsu TC and Shiau MY. Elevated circulatory MMP-2 and MMP-9 levels and activities in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Biochem 2008; 41: 955-959.
21. Kim KS, Choi HM, Lee YA, Choi IA, Lee SH, Hong SJ, Yang HI and Yoo MC. Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis. Rheumatol Int 2011; 31: 543-547.
22. Rojiani MV, Alidina J, Esposito NandRojiani AM. Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma. Int J Clin Exp Pathol 2010; 3: 775-781.
23. Badiga AV, Chetty C, Kesanakurti D, Are D, Gujrati M, Klopfenstein JD, Dinh DH and Rao JS. MMP-2 siRNA inhibits radiation-enhanced invasiveness in glioma cells. PLoS One 2011; 6: e20614.
24. Klein T and Bischoff R. Physiology and pathophysiology of matrix metalloproteases. Amino Acids 2011; 41: 271-290.
25. Christoffersson G, Vagesjo E, Vandooren J, Liden M, Massena S, Reinert RB, Brissova M, Powers AC, Opdenakker G and Phillipson M. VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Blood 2012; 120: 4653-4662.
26. Jedryka M, Chrobak A, Chelmonska-Soyta A, Gawron D, Halbersztadt A, Wojnar A and Kornafel J. Matrix metalloproteinase (MMP)-2 and MMP-9 expression in tumor infiltrating CD3 lymphocytes from women with endometrial cancer. Int J Gynecol Cancer 2012; 22: 1303-1309.
27. Carmeliet P and Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011; 473: 298-307