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Volumn 14, Issue 3, 2014, Pages 191-207

Meta-analysis of the cardiovascular outcomes with dipeptidyl peptidase 4 inhibitors: Validation of the current FDA mandate

Author keywords

[No Author keywords available]

Indexed keywords

ALOGLIPTIN; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLICLAZIDE; LINAGLIPTIN; METFORMIN; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; VILDAGLIPTIN;

EID: 84904262829     PISSN: 11753277     EISSN: 1179187X     Source Type: Journal    
DOI: 10.1007/s40256-014-0070-7     Document Type: Review
Times cited : (14)

References (92)
  • 1
    • 65349085059 scopus 로고    scopus 로고
    • Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005
    • Preis SR, Hwang SJ, Coady S, Pencina MJ, D'Agostino RB Sr, Savage PJ, Levy D, Fox CS. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation. 2009;119(13):1728-35.
    • (2009) Circulation , vol.119 , Issue.13 , pp. 1728-1735
    • Preis, S.R.1    Hwang, S.J.2    Coady, S.3    Pencina, M.J.4    D'Agostino Sr., R.B.5    Savage, P.J.6    Levy, D.7    Fox, C.S.8
  • 3
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007;356(24):2457-71. (Pubitemid 46919772)
    • (2007) New England Journal of Medicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 4
    • 0032744557 scopus 로고    scopus 로고
    • Therapy of type 2 diabetes, cardiovascular death, and the UGDP
    • DOI 10.1016/S0002-8703(99)70034-7
    • Feinglos MN, Bethel MA. Therapy of type 2 diabetes, cardiovascular death, and the UGDP. Am Heart J. 1999;138(5 Pt 1):S346-52. (Pubitemid 29523298)
    • (1999) American Heart Journal , vol.138 , Issue.5 I
    • Feinglos, M.N.1    Bethel, M.A.2
  • 5
    • 28144451163 scopus 로고    scopus 로고
    • Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
    • DOI 10.1001/jama.294.20.joc50147
    • Nissen SE, Wolski K, Topol EJ. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA. 2005;294:2581-6. (Pubitemid 41697247)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.20 , pp. 2581-2586
    • Nissen, S.E.1    Wolski, K.2    Topol, E.J.3
  • 7
    • 84869217988 scopus 로고    scopus 로고
    • Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: Meta-analysis
    • Park H, Park C, Kim Y, Rascati KL. Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysis. Ann Pharmacother. 2012;46(11):1453-69.
    • (2012) Ann Pharmacother , vol.46 , Issue.11 , pp. 1453-1469
    • Park, H.1    Park, C.2    Kim, Y.3    Rascati, K.L.4
  • 8
    • 84871936025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: A meta-analysis of randomized clinical trials
    • Monami M, Ahrén B, Dicembrini I, Mannucci E. Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials. Diabetes Obes Metab. 2013;15(2):112-20.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.2 , pp. 112-120
    • Monami, M.1    Ahrén, B.2    Dicembrini, I.3    Mannucci, E.4
  • 11
    • 84904249058 scopus 로고    scopus 로고
    • Accessed 3 Sept 2013
    • http://www.clinicaltrials.gov. Accessed 3 Sept 2013.
  • 13
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • PRISMA Group
    • Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.
    • (2009) PLoS Med , vol.6
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 14
    • 36749054399 scopus 로고    scopus 로고
    • Handbook of systematic reviews of interventions 4.2.6 (updated September 2006)
    • Chichester UK: Wiley
    • Higgins JPT, Green S, editors. Handbook of systematic reviews of interventions 4.2.6 (updated September 2006). In: The Cochrane Library. Issue 4, 2006. Chichester UK: Wiley.
    • (2006) The Cochrane Library , Issue.4
    • Higgins, J.P.T.1    Green, S.2
  • 15
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Br Med J. 1997;315:629-34. (Pubitemid 27387172)
    • (1997) British Medical Journal , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 16
    • 58149171060 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: A randomized, double-blind, placebo-controlled study
    • Alogliptin Study 010 Group
    • DeFronzo RA, Fleck PR, Wilson CA, Mekki Q, Alogliptin Study 010 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study. Diabetes Care. 2008;31(12):2315-7.
    • (2008) Diabetes Care , vol.31 , Issue.12 , pp. 2315-2317
    • DeFronzo, R.A.1    Fleck, P.R.2    Wilson, C.A.3    Mekki, Q.4
  • 17
    • 70349314675 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study
    • Alogliptin Study 009 Group
    • Pratley RE, Reusch JE, Fleck PR, Wilson CA, Mekki Q, Alogliptin Study 009 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin. 2009;25(10):2361-71.
    • (2009) Curr Med Res Opin , vol.25 , Issue.10 , pp. 2361-2371
    • Pratley, R.E.1    Reusch, J.E.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 18
    • 58149335320 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy
    • Alogliptin Study 007 Group
    • Pratley RE, Kipnes MS, Fleck PR, Wilson C, Mekki Q, Alogliptin Study 007 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy. Diabetes Obes Metab. 2009;11(2):167-76.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.2 , pp. 167-176
    • Pratley, R.E.1    Kipnes, M.S.2    Fleck, P.R.3    Wilson, C.4    Mekki, Q.5
  • 19
    • 57649225147 scopus 로고    scopus 로고
    • Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A multicentre, randomised, double-blind, placebo-controlled study
    • Alogliptin Study 008 Group
    • Nauck MA, Ellis GC, Fleck PR, Wilson CA, Mekki Q, Alogliptin Study 008 Group. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract. 2009;63(1):46-55.
    • (2009) Int J Clin Pract , vol.63 , Issue.1 , pp. 46-55
    • Nauck, M.A.1    Ellis, G.C.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 20
    • 70450173642 scopus 로고    scopus 로고
    • Alogliptin added to insulin therapy in patientswith type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia
    • Rosenstock J, Rendell MS, Gross JL, Fleck PR, Wilson CA, Mekki Q. Alogliptin added to insulin therapy in patientswith type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab. 2009;11(12):1145-52.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.12 , pp. 1145-1152
    • Rosenstock, J.1    Rendell, M.S.2    Gross, J.L.3    Fleck, P.R.4    Wilson, C.A.5    Mekki, Q.6
  • 21
    • 84860711211 scopus 로고    scopus 로고
    • Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Burant CF, Fleck P, Wilson C, Mekki Q, Pratley RE. Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes. J Clin Endocrinol Metab. 2012;97(5):1615-22.
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.5 , pp. 1615-1622
    • DeFronzo, R.A.1    Burant, C.F.2    Fleck, P.3    Wilson, C.4    Mekki, Q.5    Pratley, R.E.6
  • 22
    • 80055037047 scopus 로고    scopus 로고
    • Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: A 52-week, randomized, double-blind, active-controlled, parallel-group study
    • Bosi E, Ellis GC, Wilson CA, Fleck PR. Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study. Diabetes Obes Metab. 2011;13(12):1088-96.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.12 , pp. 1088-1096
    • Bosi, E.1    Ellis, G.C.2    Wilson, C.A.3    Fleck, P.R.4
  • 23
    • 84862813117 scopus 로고    scopus 로고
    • Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: A randomized, double-blind, placebo-controlled study
    • Haak T, Meinicke T, Jones R, Weber S, von Eynatten M, Woerle HJ. Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab. 2012;14(6):565-74.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.6 , pp. 565-574
    • Haak, T.1    Meinicke, T.2    Jones, R.3    Weber, S.4    Von Eynatten, M.5    Woerle, H.J.6
  • 24
    • 78649691630 scopus 로고    scopus 로고
    • Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study
    • Taskinen MR, Rosenstock J, Tamminen I, Kubiak R, Patel S, Dugi KA, Woerle HJ. Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab. 2011;13(1):65-74.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.1 , pp. 65-74
    • Taskinen, M.R.1    Rosenstock, J.2    Tamminen, I.3    Kubiak, R.4    Patel, S.5    Dugi, K.A.6    Woerle, H.J.7
  • 25
    • 80053072352 scopus 로고    scopus 로고
    • Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: A 24-week randomized study
    • Owens DR, Swallow R, Dugi KA, Woerle HJ. Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study. Diabet Med. 2011;28(11):1352-61.
    • (2011) Diabet Med , vol.28 , Issue.11 , pp. 1352-1361
    • Owens, D.R.1    Swallow, R.2    Dugi, K.A.3    Woerle, H.J.4
  • 26
    • 84886297885 scopus 로고    scopus 로고
    • Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: A randomised, double-blind, placebo-controlled trial
    • Epub Ahead of Print
    • Barnett AH, Huisman H, Jones R, von Eynatten M, Patel S, Woerle HJ. Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: a randomised, double-blind, placebo-controlled trial. Lancet. 2013 (Epub Ahead of Print).
    • (2013) Lancet
    • Barnett, A.H.1    Huisman, H.2    Jones, R.3    Von Eynatten, M.4    Patel, S.5    Woerle, H.J.6
  • 27
    • 84869813774 scopus 로고    scopus 로고
    • Black/African American patients with type 2 diabetes mellitus: Study design and baseline patient characteristics from a randomized clinical trial of linagliptin
    • Thrasher J, Daniels K, Patel S, Whetteckey J. Black/African American patients with type 2 diabetes mellitus: study design and baseline patient characteristics from a randomized clinical trial of linagliptin. Expert Opin Pharmacother. 2012;13(17):2443-52.
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.17 , pp. 2443-2452
    • Thrasher, J.1    Daniels, K.2    Patel, S.3    Whetteckey, J.4
  • 28
    • 84873263426 scopus 로고    scopus 로고
    • Linagliptin monotherapy in type 2 diabetes patients for whom metformin is inappropriate: An 18-week randomized, double-blind, placebo-controlled phase III trial with a 34-week active-controlled extension
    • Epub Ahead of Print
    • Barnett AH, Patel S, Harper R, Toorawa R, Thiemann S, von Eynatten M, Woerle HJ. Linagliptin monotherapy in type 2 diabetes patients for whom metformin is inappropriate: an 18-week randomized, double-blind, placebo-controlled phase III trial with a 34-week active-controlled extension. Diabetes Obes Metab. 2012 (Epub Ahead of Print).
    • (2012) Diabetes Obes Metab
    • Barnett, A.H.1    Patel, S.2    Harper, R.3    Toorawa, R.4    Thiemann, S.5    Von Eynatten, M.6    Woerle, H.J.7
  • 29
    • 84858003503 scopus 로고    scopus 로고
    • Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: A randomized, placebo and active comparator-controlled, double-blind study
    • Kawamori R, Inagaki N, Araki E, Watada H, Hayashi N, Horie Y, Sarashina A, Gong Y, von Eynatten M, Woerle HJ, Dugi KA. Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study. Diabetes Obes Metab. 2012;14(4):348-57.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.4 , pp. 348-357
    • Kawamori, R.1    Inagaki, N.2    Araki, E.3    Watada, H.4    Hayashi, N.5    Horie, Y.6    Sarashina, A.7    Gong, Y.8    Von Eynatten, M.9    Woerle, H.J.10    Dugi, K.A.11
  • 30
    • 84864757433 scopus 로고    scopus 로고
    • 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: A randomised, double-blind, non-inferiority trial
    • Gallwitz B, Rosenstock J, Rauch T, Bhattacharya S, Patel S, von Eynatten M, Dugi KA, Woerle HJ. 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet. 2012;380(9840):475-83.
    • (2012) Lancet , vol.380 , Issue.9840 , pp. 475-483
    • Gallwitz, B.1    Rosenstock, J.2    Rauch, T.3    Bhattacharya, S.4    Patel, S.5    Von Eynatten, M.6    Dugi, K.A.7    Woerle, H.J.8
  • 31
    • 79955015666 scopus 로고    scopus 로고
    • Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks
    • CV181039 Investigators
    • Pfützner A, Paz-Pacheco E, Allen E, Frederich R, Chen R, CV181039 Investigators. Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks. Diabetes Obes Metab. 2011;13(6):567-76.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.6 , pp. 567-576
    • Pfützner, A.1    Paz-Pacheco, E.2    Allen, E.3    Frederich, R.4    Chen, R.5
  • 32
    • 70349333861 scopus 로고    scopus 로고
    • Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes
    • CV181-011 Study Investigators
    • Rosenstock J, Aguilar-Salinas C, Klein E, Nepal S, List J, Chen R, CV181-011 Study Investigators. Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes. Curr Med Res Opin. 2009;25(10):2401-11.
    • (2009) Curr Med Res Opin , vol.25 , Issue.10 , pp. 2401-2411
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3    Nepal, S.4    List, J.5    Chen, R.6
  • 33
    • 79959217544 scopus 로고    scopus 로고
    • Safety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitus
    • CV181013 Investigators
    • Hollander PL, Li J, Frederich R, Allen E, Chen R, CV181013 Investigators. Safety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitus. Diab Vasc Dis Res. 2011;8(2):125-35.
    • (2011) Diab Vasc Dis Res , vol.8 , Issue.2 , pp. 125-135
    • Hollander, P.L.1    Li, J.2    Frederich, R.3    Allen, E.4    Chen, R.5
  • 34
    • 84871525992 scopus 로고    scopus 로고
    • The efficacy and safety of the dipeptidyl peptidase-4 inhibitor saxagliptin in treatment-naïve patients with type 2 diabetes mellitus: A randomized controlled trial
    • Frederich R, McNeill R, Berglind N, Fleming D, Chen R. The efficacy and safety of the dipeptidyl peptidase-4 inhibitor saxagliptin in treatment-naïve patients with type 2 diabetes mellitus: a randomized controlled trial. Diabetol Metab Syndr. 2012;4(1):36.
    • (2012) Diabetol Metab Syndr , vol.4 , Issue.1 , pp. 36
    • Frederich, R.1    McNeill, R.2    Berglind, N.3    Fleming, D.4    Chen, R.5
  • 35
    • 69549135336 scopus 로고    scopus 로고
    • The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    • Saxagliptin 014 Study Group
    • DeFronzo RA, Hissa MN, Garber AJ, Luiz Gross J, Yuyan Duan R, Ravichandran S, Chen RS, Saxagliptin 014 Study Group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care. 2009;32(9):1649-55.
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1649-1655
    • DeFronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3    Luiz Gross, J.4    Yuyan Duan, R.5    Ravichandran, S.6    Chen, R.S.7
  • 36
    • 79959211974 scopus 로고    scopus 로고
    • Safety and efficacy of saxagliptin in combination with submaximal sulphonylurea versus up-titrated sulphonylurea over 76 weeks
    • CV181040 Investigators
    • Chacra AR, Tan GH, Ravichandran S, List J, Chen R, CV181040 Investigators. Safety and efficacy of saxagliptin in combination with submaximal sulphonylurea versus up-titrated sulphonylurea over 76 weeks. Diab Vasc Dis Res. 2011;8(2):150-9.
    • (2011) Diab Vasc Dis Res , vol.8 , Issue.2 , pp. 150-159
    • Chacra, A.R.1    Tan, G.H.2    Ravichandran, S.3    List, J.4    Chen, R.5
  • 37
    • 84859731126 scopus 로고    scopus 로고
    • Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    • Barnett AH, Charbonnel B, Donovan M, Fleming D, Chen R. Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin. Curr Med Res Opin. 2012;28(4):513-23.
    • (2012) Curr Med Res Opin , vol.28 , Issue.4 , pp. 513-523
    • Barnett, A.H.1    Charbonnel, B.2    Donovan, M.3    Fleming, D.4    Chen, R.5
  • 38
    • 84875525465 scopus 로고    scopus 로고
    • Saxagliptin vs. Glipizide as add-on therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: Long-term (52-week) extension of a 52-week randomised controlled trial
    • Göke B, Gallwitz B, Eriksson JG, Hellqvist Å, Gause-Nilsson I. Saxagliptin vs. glipizide as add-on therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: long-term (52-week) extension of a 52-week randomised controlled trial. Int J Clin Pract. 2013;67(4):307-16.
    • (2013) Int J Clin Pract , vol.67 , Issue.4 , pp. 307-316
    • Göke, B.1    Gallwitz, B.2    Eriksson, J.G.3    Hellqvist, Å.4    Gause-Nilsson, I.5
  • 39
    • 84867840717 scopus 로고    scopus 로고
    • Effects of saxagliptin added to sub-maximal doses of metformin compared with uptitration of metformin in type 2 diabetes: The PROMPT study
    • Hermans MP, Delibasi T, Farmer I, Lohm L, Maheux P, Piatti P, Malvolti E, Jörgens S, Charbonnel B. Effects of saxagliptin added to sub-maximal doses of metformin compared with uptitration of metformin in type 2 diabetes: the PROMPT study. Curr Med Res Opin. 2012;28(10):1635-45.
    • (2012) Curr Med Res Opin , vol.28 , Issue.10 , pp. 1635-1645
    • Hermans, M.P.1    Delibasi, T.2    Farmer, I.3    Lohm, L.4    Maheux, P.5    Piatti, P.6    Malvolti, E.7    Jörgens, S.8    Charbonnel, B.9
  • 40
    • 84863230449 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: A randomized controlled trial
    • Pan CY, Yang W, Tou C, Gause-Nilsson I, Zhao J. Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: a randomized controlled trial. Diabetes Metab Res Rev. 2012;28(3):268-75.
    • (2012) Diabetes Metab Res Rev , vol.28 , Issue.3 , pp. 268-275
    • Pan, C.Y.1    Yang, W.2    Tou, C.3    Gause-Nilsson, I.4    Zhao, J.5
  • 41
    • 81255160603 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: A randomized controlled trial
    • Yang W, Pan CY, Tou C, Zhao J, Gause-Nilsson I. Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial. Diabetes Res Clin Pract. 2011;94(2):217-24.
    • (2011) Diabetes Res Clin Pract , vol.94 , Issue.2 , pp. 217-224
    • Yang, W.1    Pan, C.Y.2    Tou, C.3    Zhao, J.4    Gause-Nilsson, I.5
  • 42
    • 84875221492 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26-week trial in patients with type 2 diabetes
    • Fonseca V, Staels B, Morgan JD 2nd, Shentu Y, Golm GT, Johnson-Levonas AO, Kaufman KD, Goldstein BJ, Steinberg H. Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26-week trial in patients with type 2 diabetes. J Diabetes Complications. 2013;27(2):177-83.
    • (2013) J Diabetes Complications , vol.27 , Issue.2 , pp. 177-183
    • Fonseca, V.1    Staels, B.2    Morgan II, J.D.3    Shentu, Y.4    Golm, G.T.5    Johnson-Levonas, A.O.6    Kaufman, K.D.7    Goldstein, B.J.8    Steinberg, H.9
  • 43
    • 84878837962 scopus 로고    scopus 로고
    • Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: A randomised clinical trial
    • Charbonnel B, Steinberg H, Eymard E, Xu L, Thakkar P, Prabhu V, Davies MJ, Engel SS. Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial. Diabetologia. 2013;56(7):1503-11.
    • (2013) Diabetologia , vol.56 , Issue.7 , pp. 1503-1511
    • Charbonnel, B.1    Steinberg, H.2    Eymard, E.3    Xu, L.4    Thakkar, P.5    Prabhu, V.6    Davies, M.J.7    Engel, S.S.8
  • 48
    • 77952083721 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes
    • Williams-Herman D, Johnson J, Teng R, Golm G, Kaufman KD, Goldstein BJ, Amatruda JM. Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12(5):442-51.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.5 , pp. 442-451
    • Williams-Herman, D.1    Johnson, J.2    Teng, R.3    Golm, G.4    Kaufman, K.D.5    Goldstein, B.J.6    Amatruda, J.M.7
  • 49
    • 84863311010 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with sitagliptin and pioglitazone in patients with type 2 diabetes: A 54-week study
    • Yoon KH, Steinberg H, Teng R, Golm GT, Lee M, O'Neill EA, Kaufman KD, Goldstein BJ. Efficacy and safety of initial combination therapy with sitagliptin and pioglitazone in patients with type 2 diabetes: a 54-week study. Diabetes Obes Metab. 2012;14(8):745-52.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.8 , pp. 745-752
    • Yoon, K.H.1    Steinberg, H.2    Teng, R.3    Golm, G.T.4    Lee, M.5    O'Neill, E.A.6    Kaufman, K.D.7    Goldstein, B.J.8
  • 50
    • 84865309780 scopus 로고    scopus 로고
    • The addition of sitagliptin to ongoing metformin therapy significantly improves glycemic control in Chinese patients with type 2 diabetes
    • Yang W, Guan Y, Shentu Y, Li Z, Johnson-Levonas AO, Engel SS, Kaufman KD, Goldstein BJ, Alba M. The addition of sitagliptin to ongoing metformin therapy significantly improves glycemic control in Chinese patients with type 2 diabetes. J Diabetes. 2012;4(3):227-37.
    • (2012) J Diabetes , vol.4 , Issue.3 , pp. 227-237
    • Yang, W.1    Guan, Y.2    Shentu, Y.3    Li, Z.4    Johnson-Levonas, A.O.5    Engel, S.S.6    Kaufman, K.D.7    Goldstein, B.J.8    Alba, M.9
  • 51
    • 78650656671 scopus 로고    scopus 로고
    • Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: A randomized, double-blind, non-inferiority trial
    • Arechavaleta R, Seck T, Chen Y, Krobot KJ, O'Neill EA, Duran L, Kaufman KD, Williams-Herman D, Goldstein BJ. Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab. 2011;13(2):160-8.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.2 , pp. 160-168
    • Arechavaleta, R.1    Seck, T.2    Chen, Y.3    Krobot, K.J.4    O'Neill, E.A.5    Duran, L.6    Kaufman, K.D.7    Williams-Herman, D.8    Goldstein, B.J.9
  • 52
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomized trial
    • DURATION-2 Study Group
    • Bergenstal RM, Wysham C, Macconell L, Malloy J, Walsh B, Yan P, Wilhelm K, Malone J, Porter LE, DURATION-2 Study Group. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomized trial. Lancet. 2010;376(9739):431-9.
    • (2010) Lancet , vol.376 , Issue.9739 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3    Malloy, J.4    Walsh, B.5    Yan, P.6    Wilhelm, K.7    Malone, J.8    Porter, L.E.9
  • 53
    • 84862271963 scopus 로고    scopus 로고
    • Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): A multicentre, randomised open-label trial
    • EASIE investigators
    • Aschner P, Chan J, Owens DR, Picard S, Wang E, Dain MP, Pilorget V, Echtay A, Fonseca V, EASIE investigators. Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial. Lancet. 2012;379(9833):2262-9.
    • (2012) Lancet , vol.379 , Issue.9833 , pp. 2262-2269
    • Aschner, P.1    Chan, J.2    Owens, D.R.3    Picard, S.4    Wang, E.5    Dain, M.P.6    Pilorget, V.7    Echtay, A.8    Fonseca, V.9
  • 54
    • 75649128008 scopus 로고    scopus 로고
    • Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes
    • Sitagliptin Study 049 Group
    • Aschner P, Katzeff HL, Guo H, Sunga S, Williams-Herman D, Kaufman KD, Goldstein BJ, Sitagliptin Study 049 Group. Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12(3):252-61.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.3 , pp. 252-261
    • Aschner, P.1    Katzeff, H.L.2    Guo, H.3    Sunga, S.4    Williams-Herman, D.5    Kaufman, K.D.6    Goldstein, B.J.7
  • 55
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Sitagliptin Study 023 Group
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H, Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49(11):2564-71.
    • (2006) Diabetologia , vol.49 , Issue.11 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 56
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, open-label trial
    • 1860 LIRA-DPP-4 Study Group
    • Pratley R, Nauck M, Bailey T, Montanya E, Cuddihy R, Filetti S, Garber A, Thomsen AB, Hartvig H, Davies M, 1860 LIRA-DPP-4 Study Group. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract. 2011;65(4):397-407.
    • (2011) Int J Clin Pract , vol.65 , Issue.4 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Cuddihy, R.5    Filetti, S.6    Garber, A.7    Thomsen, A.B.8    Hartvig, H.9    Davies, M.10
  • 58
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: A randomised trial
    • Epub ahead of print
    • Lavalle-González FJ, Januszewicz A, Davidson J, Tong C, Qiu R, Canovatchel W, Meininger G. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial. Diabetologia. 2013 (Epub ahead of print).
    • (2013) Diabetologia
    • Lavalle-González, F.J.1    Januszewicz, A.2    Davidson, J.3    Tong, C.4    Qiu, R.5    Canovatchel, W.6    Meininger, G.7
  • 59
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • DOI 10.1016/j.clinthera.2006.10.007, PII S0149291806002475
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P, Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2006;28(10):1556-68. (Pubitemid 44841980)
    • (2006) Clinical Therapeutics , vol.28 , Issue.10 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3    Lu, K.4    Stein, P.5
  • 60
    • 34547863123 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • DOI 10.1111/j.1463-1326.2007.00744.x
    • Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P, Sitagliptin Study 035 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab. 2007;9(5):733-45. (Pubitemid 47261855)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.5 , pp. 733-745
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3    Fanurik, D.4    Khatami, H.5    Stein, P.6
  • 61
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): A 26-week double-blind study
    • DURATION-4 Study Group
    • Russell-Jones D, Cuddihy RM, Hanefeld M, Kumar A, González JG, Chan M, Wolka AM, Boardman MK, DURATION-4 Study Group. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care. 2012;35(2):252-8.
    • (2012) Diabetes Care , vol.35 , Issue.2 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3    Kumar, A.4    González, J.G.5    Chan, M.6    Wolka, A.M.7    Boardman, M.K.8
  • 62
    • 84881189911 scopus 로고    scopus 로고
    • Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): A 24 week, randomised, double-blind, placebo-controlled study
    • Strain WD, Lukashevich V, Kothny W, Hoellinger MJ, Paldánius PM. Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. Lancet. 2013;382(9890):409-16.
    • (2013) Lancet , vol.382 , Issue.9890 , pp. 409-416
    • Strain, W.D.1    Lukashevich, V.2    Kothny, W.3    Hoellinger, M.J.4    Paldánius, P.M.5
  • 63
    • 44949170696 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia
    • DOI 10.1111/j.1463-1326.2008.00850.x
    • Scherbaum WA, Schweizer A, Mari A, Nilsson PM, Lalanne G, Jauffret S, Foley JE. Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia*. Diabetes Obes Metab. 2008;10(8):675-82. (Pubitemid 352044298)
    • (2008) Diabetes, Obesity and Metabolism , vol.10 , Issue.8 , pp. 675-682
    • Scherbaum, W.A.1    Schweizer, A.2    Mari, A.3    Nilsson, P.M.4    Lalanne, G.5    Jauffret, S.6    Foley, J.7
  • 65
    • 65549109984 scopus 로고    scopus 로고
    • Long-term 2-year safety and efficacy of vildagliptin compared with rosiglitazone in drug-naïve patients with type 2 diabetes mellitus
    • Rosenstock J, Niggli M, Maldonado-Lutomirsky M. Long-term 2-year safety and efficacy of vildagliptin compared with rosiglitazone in drug-naïve patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2009;11(6):571-8.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.6 , pp. 571-578
    • Rosenstock, J.1    Niggli, M.2    Maldonado-Lutomirsky, M.3
  • 66
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: A 24-week, double-blind, randomized trial
    • DOI 10.2337/dc06-1815
    • Rosenstock J, Baron MA, Dejager S, Mills D, Schweizer A. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care. 2007;30(2):217-23. (Pubitemid 46198322)
    • (2007) Diabetes Care , vol.30 , Issue.2 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3    Mills, D.4    Schweizer, A.5
  • 67
    • 65449135133 scopus 로고    scopus 로고
    • Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus
    • Bosi E, Dotta F, Jia Y, Goodman M. Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2009;11(5):506-15.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.5 , pp. 506-515
    • Bosi, E.1    Dotta, F.2    Jia, Y.3    Goodman, M.4
  • 68
    • 34247874561 scopus 로고    scopus 로고
    • Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    • DOI 10.1007/s00125-007-0633-0
    • Fonseca V, Schweizer A, Albrecht D, Baron MA, Chang I, Dejager S. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes. Diabetologia. 2007;50(6):1148-55. (Pubitemid 46701545)
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1148-1155
    • Fonseca, V.1    Schweizer, A.2    Albrecht, D.3    Baron, M.A.4    Chang, I.5    Dejager, S.6
  • 69
    • 41749106662 scopus 로고    scopus 로고
    • Comparison of vildagliptin and acarbose monotherapy in patients with type 2 diabetes: A 24-week, double-blind, randomized trial
    • DOI 10.1111/j.1464-5491.2008.02391.x
    • Pan C, Yang W, Barona JP, Wang Y, Niggli M, Mohideen P, Wang Y, Foley JE. Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, doubleblind, randomized trial. Diabet Med. 2008;25(4):435-41. (Pubitemid 351490110)
    • (2008) Diabetic Medicine , vol.25 , Issue.4 , pp. 435-441
    • Pan, C.1    Yang, W.2    Barona, J.P.3    Wang, Y.4    Niggli, M.5    Mohideen, P.6    Wang, Y.7    Foley, J.E.8
  • 70
    • 84863312882 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus
    • Institution Investigators
    • Pan C, Xing X, Han P, Zheng S, Ma J, Liu J, Lv X, Lu J, Bader G, Institution Investigators. Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2012;14(8):737-44.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.8 , pp. 737-744
    • Pan, C.1    Xing, X.2    Han, P.3    Zheng, S.4    Ma, J.5    Liu, J.6    Lv, X.7    Lu, J.8    Bader, G.9
  • 71
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • DOI 10.2337/dc06-1732
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with met-formin. Diabetes Care. 2007;30(4):890-5. (Pubitemid 46556583)
    • (2007) Diabetes Care , vol.30 , Issue.4 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 72
    • 65549131200 scopus 로고    scopus 로고
    • Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin
    • Bolli G, Dotta F, Colin L, Minic B, Goodman M. Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Obes Metab. 2009;11(6):589-95.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.6 , pp. 589-595
    • Bolli, G.1    Dotta, F.2    Colin, L.3    Minic, B.4    Goodman, M.5
  • 73
    • 58149330590 scopus 로고    scopus 로고
    • Fifty-two-week efficacy and safety of vildagliptin vs. Glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    • Ferrannini E, Fonseca V, Zinman B, Matthews D, Ahrén B, Byiers S, Shao Q, Dejager S. Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes Obes Metab. 2009;11(2):157-66.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.2 , pp. 157-166
    • Ferrannini, E.1    Fonseca, V.2    Zinman, B.3    Matthews, D.4    Ahrén, B.5    Byiers, S.6    Shao, Q.7    Dejager, S.8
  • 74
    • 67949105103 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy
    • Goodman M, Thurston H, Penman J. Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy. Horm Metab Res. 2009;41(5):368-73.
    • (2009) Horm Metab Res , vol.41 , Issue.5 , pp. 368-373
    • Goodman, M.1    Thurston, H.2    Penman, J.3
  • 75
    • 71849095372 scopus 로고    scopus 로고
    • Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes
    • Foley JE, Sreenan S. Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes. Horm Metab Res. 2009;41(12):905-9.
    • (2009) Horm Metab Res , vol.41 , Issue.12 , pp. 905-909
    • Foley, J.E.1    Sreenan, S.2
  • 76
    • 34548118796 scopus 로고    scopus 로고
    • 1c over 1 year in drug-naïve patients with Type 2 diabetes
    • DOI 10.1111/j.1464-5491.2007.02191.x
    • Schweizer A, Couturier A, Foley JE, Dejager S. Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with Type 2 diabetes. Diabet Med. 2007;24(9):955-61. (Pubitemid 47301637)
    • (2007) Diabetic Medicine , vol.24 , Issue.9 , pp. 955-961
    • Schweizer, A.1    Couturier, A.2    Foley, J.E.3    Dejager, S.4
  • 77
    • 67649933635 scopus 로고    scopus 로고
    • Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: A 24-week, double-blind, randomized trial
    • Schweizer A, Dejager S, Bosi E. Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Obes Metab. 2009;11(8):804-12.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.8 , pp. 804-812
    • Schweizer, A.1    Dejager, S.2    Bosi, E.3
  • 78
    • 80052551137 scopus 로고    scopus 로고
    • Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: A prospective 24-week randomized placebo-controlled trial
    • Lukashevich V, Schweizer A, Shao Q, Groop PH, Kothny W. Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial. Diabetes Obes Metab. 2011;13(10):947-54.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.10 , pp. 947-954
    • Lukashevich, V.1    Schweizer, A.2    Shao, Q.3    Groop, P.H.4    Kothny, W.5
  • 79
    • 84859438114 scopus 로고    scopus 로고
    • Safety and tolerability of linagliptin: A pooled analysis of data from randomized controlled trials in 3572 patients with type 2 diabetes mellitus
    • Schernthaner G, Barnett AH, Emser A, Patel S, Troost J, Woerle HJ, von Eynatten M. Safety and tolerability of linagliptin: a pooled analysis of data from randomized controlled trials in 3572 patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2012;14(5):470-8.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.5 , pp. 470-478
    • Schernthaner, G.1    Barnett, A.H.2    Emser, A.3    Patel, S.4    Troost, J.5    Woerle, H.J.6    Von Eynatten, M.7
  • 80
    • 79952651976 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in older patients with type 2 diabetes mellitus
    • Doucet J, Chacra A, Maheux P, Lu J, Harris S, Rosenstock J. Efficacy and safety of saxagliptin in older patients with type 2 diabetes mellitus. Curr Med Res Opin. 2011;27(4):863-9.
    • (2011) Curr Med Res Opin , vol.27 , Issue.4 , pp. 863-869
    • Doucet, J.1    Chacra, A.2    Maheux, P.3    Lu, J.4    Harris, S.5    Rosenstock, J.6
  • 81
    • 81855194761 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of randomized clinical trials
    • Monami M, Dicembrini I, Martelli D, Mannucci E. Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials. Curr Med Res Opin. 2011;27(Suppl 3):57-64.
    • (2011) Curr Med Res Opin , vol.27 , Issue.SUPPL. 3 , pp. 57-64
    • Monami, M.1    Dicembrini, I.2    Martelli, D.3    Mannucci, E.4
  • 82
    • 84884930937 scopus 로고    scopus 로고
    • The cardiovascular safety of diabetes drugs-insights from the rosiglitazone experience
    • Epub ahead of print
    • Hiatt WR, Kaul S, Smith RJ. The cardiovascular safety of diabetes drugs-insights from the rosiglitazone experience. N Engl J Med. 2013 (Epub ahead of print).
    • (2013) N Engl J Med
    • Hiatt, W.R.1    Kaul, S.2    Smith, R.J.3
  • 84
    • 77953182696 scopus 로고    scopus 로고
    • Assessing the cardio-cerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large Phase III type 2 diabetes population
    • Schweizer A, Dejager S, Foley JE, Couturier A, Ligueros-Saylan M, Kothny W. Assessing the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated events from a large Phase III type 2 diabetes population. Diabetes Obes Metab. 2010;12(6):485-94.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.6 , pp. 485-494
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3    Couturier, A.4    Ligueros-Saylan, M.5    Kothny, W.6
  • 85
    • 77957652845 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokines
    • Takasawa W, Ohnuma K, Hatano R, Endo Y, Dang NH, Morimoto C. Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokines. Biochem Biophys Res Commun. 2010;401(1):7-12.
    • (2010) Biochem Biophys Res Commun , vol.401 , Issue.1 , pp. 7-12
    • Takasawa, W.1    Ohnuma, K.2    Hatano, R.3    Endo, Y.4    Dang, N.H.5    Morimoto, C.6
  • 86
    • 77951934948 scopus 로고    scopus 로고
    • DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease
    • Read PA, Khan FZ, Heck PM, Hoole SP, Dutka DP. DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circ Cardiovasc Imaging. 2010;3(2):195-201.
    • (2010) Circ Cardiovasc Imaging , vol.3 , Issue.2 , pp. 195-201
    • Read, P.A.1    Khan, F.Z.2    Heck, P.M.3    Hoole, S.P.4    Dutka, D.P.5
  • 87
    • 77958195997 scopus 로고    scopus 로고
    • The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: Possible role of stromal-derived factor-1alpha
    • Fadini GP, Boscaro E, Albiero M, Menegazzo L, Frison V, de Kreutzenberg S, Agostini C, Tiengo A, Avogaro A. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care. 2010;33(7):1607-9.
    • (2010) Diabetes Care , vol.33 , Issue.7 , pp. 1607-1609
    • Fadini, G.P.1    Boscaro, E.2    Albiero, M.3    Menegazzo, L.4    Frison, V.5    De Kreutzenberg, S.6    Agostini, C.7    Tiengo, A.8    Avogaro, A.9
  • 91
    • 72149087737 scopus 로고    scopus 로고
    • Effect of intensive glycemic control on cardiovascular outcomes and all-cause mortality in type 2 diabetes: Overview and metaanalysis of five trials
    • Tkác I. Effect of intensive glycemic control on cardiovascular outcomes and all-cause mortality in type 2 diabetes: Overview and metaanalysis of five trials. Diabetes Res Clin Pract. 2009;86(Suppl 1):S57-62.
    • (2009) Diabetes Res Clin Pract , vol.86 , Issue.SUPPL. 1
    • Tkác, I.1
  • 92
    • 29144453326 scopus 로고    scopus 로고
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353(25):2643-53.
    • (2005) N Engl J Med , vol.353 , Issue.25 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3    Genuth, S.M.4    Lachin, J.M.5    Orchard, T.J.6    Raskin, P.7    Zinman, B.8


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