Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395

Addiction Biology

Volumn 19, Issue 4, 2014, Pages 606-611

  Simms, Jeffrey A ^a   Nielsen, Carsten K ^a   Li, Rui ^a   Bartlett, Selena E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

CP 376395; CRF; ethanol; hypothalamus; intermittent access

Indexed keywords

ALCOHOL; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 ANTAGONIST; CP 376395; GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; (3,6-DIMETHYL-2-(2,4,6-TRIMETHYLPHENOXY)PYRIDIN-4-YL)(1-ETHYLPROPYL)AMINE; AMINOPYRIDINE DERIVATIVE; CENTRAL DEPRESSANT AGENT;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL USE DISORDER; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; FEEDING BEHAVIOR; GTPGAMMAS BINDING ASSAY; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; ANALYSIS OF VARIANCE; ANIMAL; DRINKING BEHAVIOR; DRUG EFFECTS; LONG EVANS RAT; PATHOPHYSIOLOGY;

ALCOHOL DRINKING; AMINOPYRIDINES; ANALYSIS OF VARIANCE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CORTICOTROPIN-RELEASING HORMONE; ETHANOL; HYPOTHALAMUS; MALE; MODELS, ANIMAL; RATS; RATS, LONG-EVANS;

EID: 84904257765     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12024     Document Type: Article

References (12)

1. Chen YL, Obach RS, Braselton J, Corman ML, Forman J, Freeman J, Gallaschun RJ, Mansbach R, Schmidt AW, Sprouse JS, Tingley FD III, Winston E, Schulz DW, (2008) 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem 51: 1385-1392. (Pubitemid 351480399)
2. Cippitelli A, Damadzic R, Singley E, Thorsell A, Ciccocioppo R, Eskay RL, Heilig M, (2012) Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats. Pharmacol Biochem Behav 100: 522-529.
3. Koob GF, (2010) The role of CRF and CRF-related peptides in the dark side of addiction. Brain Res 1314: 3-14.
4. Lee S, Rivier C, (1993) Effect of exposure to an alcohol diet for 10 days on the ability of interleukin-1 beta to release ACTH and corticosterone in the adult ovariectomized female rat. Alcohol Clin Exp Res 17: 1009-1013. (Pubitemid 24000518)
5. Lowery EG, Spanos M, Navarro M, Lyons AM, Hodge CW, Thiele TE, (2010) CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. Neuropsychopharmacology 35: 1241-1252.
6. Lowery-Gionta EG, Navarro M, Li C, Pleil KE, Rinker JA, Cox BR, Sprow GM, Kash TL, Thiele TE, (2012) Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci 32: 3405-3413.
7. Nielsen CK, Simms JA, Li R, Mill D, Yi H, Feduccia AA, Santos N, Bartlett SE, (2012) Delta-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats. J Neurosci 32: 4540-4552.
8. Rasmussen DD, Boldt BM, Bryant CA, Mitton DR, Larsen SA, Wilkinson CW, (2000) Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis. Alcohol Clin Exp Res 24: 1836-1849. (Pubitemid 32001855)
9. Sabino V, Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP, (2006) Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology (Berl) 189: 175-186. (Pubitemid 44691540)
10. Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, Wise R, Bartlett SE, (2008) Intermittent access to 20% ethanol induces high ethanol consumption in long-evans and wistar rats. Alcohol Clin Exp Res 32: 1816-1823.
11. Sparta DR, Sparrow AM, Lowery EG, Fee JR, Knapp DJ, Thiele TE, (2008) Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark procedures. Alcohol Clin Exp Res 32: 259-265.
12. Tannahill LA, Dow RC, Fairhall KM, Robinson IC, Fink G, (1988) Comparison of adrenocorticotropin control in Brattleboro, Long-Evans, and Wistar rats. Measurement of corticotropin-releasing factor, arginine vasopressin, and oxytocin in hypophysial portal blood. Neuroendocrinology 48: 650-657. (Pubitemid 19005735)