Urinary podocalyxin as a marker of preeclampsia in a Hispanic population

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 6, Issue 2, 2014, Pages 115-124

  de Franco, Ylbe Palacios ^a,b   Velazquez, Karina ^b   Segovia, Natalia ^b   Acosta, Carolina ^b   Yanosky, Deborah ^b   Franco Palacios, Ylbe V ^c   Ramos, Amanda ^d   Franco Palacios, Carlos R ^e  

^a UNIVERSIDAD CATÓLICA NUESTRA SEÑORA DE LA ASUNCIÓN   (Paraguay)

^b Hospital Militar Central   (Paraguay)

^c Department of Obstetrics and Gynecology Complete Care Health Network South Jersey General Hospital   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

^e Graduate Program in Nurse Anesthesia   (United States)

Author keywords

Biomarkers; Hypertension; Podocalyxin; Preeclampsia; Proteinuria

Indexed keywords

EID: 84904253946     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ananth CV, Keyes KM, Wapner RJ. Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis. BMJ 2013 Nov 7; 347: f6564.
2. Bilano VL, Ota E, Ganchimeg T, Mori R, Souza JP. Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low-and middle-income countries: aWHO secondary analysis. PLoS One 2014 Mar 21; 9: e91198.
3. Garovic VD, Wagner SJ, Turner ST, Rosenthal DW, Watson WJ, Brost BC, Rose CH, Gavrilova L, Craigo P, Bailey KR, Achenbach J, Schiffer M, Grande JP. Urinary podocyte excretion as a marker for preeclampsia. Am J Obstet Gynecol 2007; 196: 320, e1-320, e7.
4. Sassetti C, Tangemann K, Singer MS, Kershaw DB, Rosen SD. Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. J Exp Med 1998; 187: 1965-75.
5. Miettinen A, Solin ML, Reivinen J, Juvonen E, Vaisanen R, Holthofer H. Podocalyxin in rat platelets and megakaryocytes. Am J Pathol 1999; 154: 813-822.
6. Kelder TP, Penning ME, Uh HW, Cohen D, Bloemenkamp KW, Bruijn JA, Scherjon SA, Baelde HJ. Quantitative polymerase chain reaction-based analysis of podocyturia is a feasible diagnostic tool in preeclampsia. Hypertension 2012; 60: 1538-44.
7. Wang Y, Zhao S, Loyd S, Groome LJ. Increased urinary excretion of nephrin, podocalyxin, and βig-h3 in women with preeclampsia. Am J Physiol Renal Physiol 2012; 302: F1084-9.
8. ACOG Committee on Obstetric Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002; 77: 67-75.
9. Smith MC, Moran P, Ward MK, Davison JM. Assessment of glomerular filtration rate during pregnancy using the MDRD formula. BJOG 2008; 115: 109-112.
10. Alper AB, Yi Y, Webber LS, Pridjian G, Mumuney AA, Saade G, Morgan J, Nuwayhid B, Belfort M, Puschett J. Estimation of glomerular filtration rate in preeclamptic patients. Am J Perinatol 2007; 24: 569-574.
11. Palacios de Franco Y. Manejo de la hipertension arterial en el embarazo. Anales de la Facultad de Ciencia Medicas. V XXIX 1996; 1816-8949.
12. Palacios de Franco Y. Hipertensin arterial y embarazo. In: Antonio Ruoti, editor. Obstetricia y Perinatologia. 2nd Ed. Asuncion; EFACIM-EDUNA; 2000. pp. 571-586. ISBN 9992-5306.
13. Bramham K, Poli-de-Figueiredo CE, Seed PT, Briley AL, Poston L, Shennan AH, Chappell LC. Association of proteinuria threshold in pre-eclampsia with maternal and perinatal outcomes: a nested case control cohort of high risk women. PLoS One 2013; 8: e76083.
14. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA; CPEP Study Group. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006; 355: 992-1005.
15. Yu D, Petermann A, Kunter U, Rong S, Shankland SJ, Floege J. Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J Am Soc Nephrol 2005; 16: 1733-41.
16. Nakamura T, Ushiyama C, Suzuki S, Hara M, Shimada N, Sekizuka K, Ebihara I, Koide H. Urinary podocytes for the assessment of disease activity in lupus nephritis. Am J Med Sci 2000; 320: 112-6.
17. Craici IM, Wagner SJ, Bailey KR, Fitz-Gibbon PD, Wood-Wentz CM, Turner ST, Hayman SR, White WM, Brost BC, Rose CH, Grande JP, Garovic VD. Podocyturia predates proteinuria and clinical features of preeclampsia: longitudinal prospective study. Hypertension 2013; 61: 1289-96.
18. Hara M, Yamamoto T, Yanagihara T, Takada T, Itoh M, Adachi Y, Yoshizumi A, Kawasaki K, Kihara I. Urinary excretion of podocalyxin indicates glomerular epithelial cell injuries in glomerulonephritis. Nephron 1995; 69: 397-403.
19. Hara M, Yanagihara T, Kihara I. Urinary podocytes in primary focal segmental glomerulosclerosis. Nephron 2001; 89: 342-347.
20. Hara M, Yanagihara T, Kihara I. Cumulative excretion of urinary podocytes reflects disease progression in IgA nephropathy and Schönlein-Henoch purpura nephritis. Clin J Am Soc Nephrol 2007; 2: 231-8.
21. Sabino AR, Teixeira VD, Nishida SK, Sass N, Mansur JB, Kirsztajn GM. Detection of podocyturia in patients with lupus nephritis. J Bras Nefrol. 2013 Dec;35(4):252-258.
22. Kanno K, Kawachi H, Uchida Y, Hara M, Shimizu F, Uchiyama M. Urinary sediment podocalyxin in children with glomerular diseases. Nephron Clin Pract. 2003; 95: c91-9.
23. Berks D, Steegers EA, Molas M, Visser W. Resolution of hypertension and proteinuria after preeclampsia. Obstet Gynecol 2009; 114: 1307-14.
24. Somasiri A, Nielsen JS, Makretsov N, McCoy ML, Prentice L, Gilks CB, Chia SK, Gelmon KA, Kershaw DB, Huntsman DG, McNagny KM, Roskelley CD. Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression. Cancer Res 2004; 64: 5068-5073.
25. Eknoyan G, Hostetter T, Bakris GL, Hebert L, Levey AS, Parving HH, Steffes MW, Toto R: Proteinuria and other markers of chronic kidney disease: A position statement of the National Kidney Foundation (NKF) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Am J Kidney Dis 42: 617-622, 2003.
26. Rodriguez-Thompson D, Lieberman ES. Use of a random urinary protein-to-creatinine ratio for the diagnosis of significant proteinuria during pregnancy. Am J Obstet Gynecol 2001; 185: 808-811.
27. Morris RK, Riley RD, Doug M, Deeks JJ, Kilby MD. Diagnostic accuracy of spot urinary protein and albumin to creatinine ratios for detection of significant proteinuria or adverse pregnancy outcome in patients with suspected pre-eclampsia: systematic review and meta-analysis. BMJ 2012 Jul 9; 345: e4342.