Co-delivery of dexamethasone and green tea polyphenols using electrospun ultrafine fibers for effective treatment of Keloid

Pharmaceutical Research

Volumn 31, Issue 7, 2014, Pages 1632-1643

  Li, Jinrong ^a   Fu, Rong ^b   Li, Long ^a   Yang, Guang ^a   Ding, Shan ^a   Zhong, Zhendong ^b   Zhou, Shaobing ^a  

^a SOUTHWEST JIAOTONG UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Biodegradable; Drug delivery; Electrospinning; Polymer; Ultrafine

Indexed keywords

COLLAGEN FIBER; DEXAMETHASONE; ERYTHROMYCIN; GREEN TEA POLYPHENOL; NANOFIBER; POLYGLACTIN; POLYPHENOL; SILICONE GEL; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; TEA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; COLLAGEN DEGRADATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; ELECTROSPINNING; ESCHERICHIA COLI; HUMAN; HUMAN TISSUE; HYDROPHILICITY; IN VIVO STUDY; INFECTION RESISTANCE; KELOID; MOUSE; NANOFABRICATION; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SKIN PENETRATION; TEA; WOUND DRESSING; ANIMAL; BANDAGE; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; PATHOLOGY; PROCEDURES; SKIN; TOPICAL DRUG ADMINISTRATION; ULTRASTRUCTURE;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BANDAGES; CELLS, CULTURED; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; HUMANS; KELOID; LACTIC ACID; MICE; MICE, NUDE; NANOFIBERS; POLYGLYCOLIC ACID; POLYPHENOLS; SKIN; TEA;

EID: 84904248050     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1266-2     Document Type: Article

References (41)

1. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341(10):738-46.
2. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453(7193):314-21.
3. Atiyeh BS, Costagliola M, Hayek SN. Keloid or hypertrophic scar: the controversy: review of the literature. Ann Plast Surg. 2005;54(6):676-80.
4. Alster TS, Williams CM. Treatment of keloid sternotomy scars with 585 nm flashlamp-pumped pulsed-dye laser. Lancet. 1995;345(8959):1198-200.
5. Butler PD, Longaker MT, Yang GP. Current progress in keloid research and treatment. J Am Coll Surg. 2008;206(4):731-41.
6. Lutgendorf MA, Adriano EM, Taylor BJ. Prevention and management of keloid scars. Obstet Gynecol. 2011;118(2):351-6.
7. Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002;96(1):23-43.
8. Reish RG, Eriksson E. Scar treatments: preclinical and clinical studies. J Am Coll Surg. 2008;206(4):719-30.
9. O'Brien L, Pandit A. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2006;1:1-32.
10. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008;26(11):1261-8.
11. Huang C, Lucas B, Vervaet C, Braeckmans K, Van Calenbergh S, Karalic I, et al. Unbreakable codes in electrospun fibers: digitally encoded polymers to stop medicine counterfeiting. Adv Mater. 2010;22(24):2657-62.
12. Sofokleous P, Stride E, Edirisinghe M. Preparation, Characterization, and Release of Amoxicillin from Electrospun Fibrous Wound Dressing Patches. Pharmaceut Res. 2013;30(7):1926-38.
13. Dong B, Smith ME, Wnek GE. Encapsulation of multiple biological compounds within a single electrospun fiber. Small. 2009;5(13):1508-12.
14. Bashur CA, Dahlgren LA, Goldstein AS. Effect of fiber diameter and orientation on fibroblast morphology and proliferation on electrospun poly(D, L-lactic-co-glycolic acid) meshes. Biomaterials. 2006;27(33):5681-8.
15. Bhardwaj N, Kundu SC. Electrospinning: A fascinating fiber fabrication technique. Biotechnol Adv. 2010;28(3):325-47.
16. Ji W, Sun Y, Yang F, van den Beucken J, Fan M, Chen Z, et al. Bioactive electrospun scaffolds delivering growth factors and genes for tissue engineering applications. Pharmaceut Res. 2011;28(6):1259-72.
17. MacNeil S. Progress and opportunities for tissue-engineered skin. Nature. 2007;445(7130):874-80.
18. Rho KS, Jeong L, Lee G, Seo BM, Park YJ, Hong SD, et al. Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials. 2006;27(8):1452-61.
19. Lalani R, Liu LY. Electrospun zwitterionic poly(sulfobetaine methacrylate) for nonadherent, superabsorbent, and antimicrobial wound dressing applications. Biomacromolecules. 2012;13(6):1853-63.
20. Wu WS, Wang FS, Yang KD, Huang CC, Kuo YR. Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation. J Invest Dermatol. 2006;126(6):1264-71.
21. Lamy S, Gingras D, Beliveau R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res. 2002;62(2):381-5.
22. Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L.). Antimicrob Agents Chemother. 1995;39(11):2375-7.
23. Gordon NC, Wareham DW. Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia. Int J Antimicrob Agents. 2010;36(2):129-31.
24. Zhou SB, Deng XM, Yang H. Biodegradable poly(ε-caprolactone)- poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. Biomaterials. 2003;24(20):3563-70.
25. Luo C, Li L, Li J, Yang G, Ding S, Zhi W, et al. Modulating cellular behaviors through surface nanoroughness. J Mater Chem. 2012;22(31):15654-64.
26. Shao SJ, Zhou SB, Li L, Li J, Luo C, Wang J, et al. Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers. Biomaterials. 2011;32(11):2821-33.
27. Shetlar MR, Shetlar CL, Hendricks L, Kischer CW. The Use of Athymic Nude Mice for the Study of Human Keloids. Experimental Biology and Medicine. 1985;179(4):549-52.
28. Chen T, Guo X, Liu X, Shi S, Wang J, Shi C, et al. A strategy in the design of micellar shape for cancer therapy. Adv Healthc Mater. 2012;1(2):214-24.
29. Jayakumar R, Prabaharan M, Sudheesh Kumar PT, Nair SV, Tamura H. Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv. 2011;29(3):322-37.
30. Chew SY, Hufnagel TC, Lim CT, Leong KW. Mechanical properties of single electrospun drug-encapsulated nanofibres. Nanotechnology. 2006;17(15):3880-91.
31. Blasi P, D'Souza SS, Selmin F, DeLuca PP. Plasticizing effect of water on poly(lactide-co-glycolide). J Control Release. 2005;108(1):1-9.
32. Ma K, Yong T, Chan KC, Ramakrishna S. Collagen-blended biodegradable polymer nanofibers: potential substrates for wound healing in skin tissue engineering. Proc Fifth IASTED Inter Conf Biomed Eng ACTA Press Anaheim CA 2007:262-266.
33. Dong YX, Liao SS, Ngiam M, Chan CK, Ramakrishna S. Degradation behaviors of electrospun resorbable polyester nanofibers. Tissue Eng Part B Rev. 2009;15(3):333-51.
34. Deng XM, Zhou SB, Li X, Zhao J, Yuan M. In vitro degradation and release profiles for poly-dl-lactide-poly(ethylene glycol) microspheres containing human serum albumin. J Control Release. 2001;71(2):165-73.
35. Luong-Van E, Grøndahl L, Chua KN, Leong KW, Nurcombe V, Cool SM. Controlled release of heparin from poly(ε-caprolactone) electrospun fibers. Biomaterials. 2006;27(9):2042-50.
36. Szentivanyi A, Chakradeo T, Zernetsch H, Glasmacher B. Electrospun cellular microenvironments: understanding controlled release and scaffold structure. Adv Drug Deliver Rev. 2011;63(4-5):209-20.
37. Vasilev K, Cook J, Griesser HJ. Antibacterial surfaces for biomedical devices. Expert Rev Med Devices. 2009;6(5):553-67.
38. Friedman M. Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Mol Nutr Food Res. 2007;51(1):116-34.
39. Sharma A, Gupta S, Sarethy IP, Dang S, Gabrani R. Green tea extract: possible mechanism and antibacterial activity on skin pathogens. Food Chem. 2012;135(2):672-5.
40. Giugliano G, Pasquali D, Notaro A, Brongo S, Nicoletti G, D'Andrea F, et al. Verapamil inhibits interleukin-6 and vascular endothelial growth factor production in primary cultures of keloid fibroblasts. Br J Plast Surg. 2003;56(8):804-9.
41. Sidle DM, Kim H. Keloids: prevention and management. Facial Plast Surg Clin North Am. 2011;19(3):505515.