Development and in vitro-in vivo evaluation of oral drug delivery system of acyclovir loaded PLGA nanoparticles

International Journal of Drug Delivery

Volumn 5, Issue 3, 2013, Pages 331-343

  Bhosale, U V ^a   Devi, Kusum ^a   Choudhary, S ^a  

^a AL AMEEN COLLEGE OF PHARMACY   (India)

Author keywords

3 factorial design; Acyclovir; In vitro in vivo evaluation; Nanoparticles; PLGA; Sustained release

Indexed keywords

ACICLOVIR; NANOPARTICLE; POLOXAMER; POLYGLACTIN;

ANALYTICAL PARAMETERS; ARTICLE; BIOAVAILABILITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG ENTRAPMENT; DRUG RELEASE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PARTICLE SIZE; POLYDISPERSITY ANALYSIS; POWDER FLOW; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

EID: 84904112824     PISSN: None     EISSN: 09750215     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Emmert DH, Treatment of common cutaneous Herpes Simplex Virus Infections. Am. Fam. Physician. 2000;61:1697-704.
2. Madhivanan, Purnima et al. The Epidemiology of Herpes Simplex Virus Type-2 Infection among Married Women in Mysore. India. Am. Sex. Tran. Diseas. Asso. 2007;34(11):935-37.
3. Tran T, Druce J, Catton MC, Kelly H, Birch CJ. Changing epidemiology of genital herpes simplex virus infection in Melbourne, Australia, between 1980 and 2003. Sex Transm Infect. 2004;80,277-79.
4. Wagstaff AG, Faulds D, Goa KL. Aciclovir: A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.1994; Drugs. 47,153-205.
5. Roser M, Fischer D, Kissel T. Surfacemodified biodegradable albumin nanoand microspheres. Eur J Pharm Biopharm.1998;46:255-63.
6. Claudia G et al. Influence of Preparation Conditions on Acyclovir-Loaded Poly-d, l-Lactic Acid Nanospheres and Effect of PEG Coating on Ocular Drug Bioavailability. Pharma. Res. 2004;20(4): 551-62.
7. Giovanna Rassu, Elisabetta Gavini, Gianpiera Spada and Paolo Giunchedi. Ketoprofen spray-dried microspheres based on eudragit®RS and RL: Study of the manufacturing parameters. Drug Develop and Indus. Pharm.2004;34:1178-87.
8. Jeon HJ, Jeong YI, Jang MK, Park YH, Nah JW. Effect of solvent on the preparation of surfactant free poly (DLlactide-coglycolide) nanoparticle and norfloxacin release characteristics. Int J Pharm.2000; 207:99-108.
9. Korsmeyer RW, Gurny R, Doelker EM, Buri P, Peppas NA. Int J Pharm. 1983;15:25-35.
10. Dressman, J.B. Gastrointestinal variables. In Oral Absorption: Prediction and Assessment. Dressman, J. B. and Lennerias, H., 1-17. New York: Marcel Dekker.
11. Sachin B. K. Formulation and evaluation of a gastro retentive drug delivery system of a model H2-blocker. J. Pharm. Research.2007;1:24-28.
12. Gohel M, Patel M, Amin A, Agarwal A, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech.2004;5(3):36.
13. Govender T, Stolnik S, Garnett MC, Illum L, Davis SS. PLGA nanoparticles prepared by nanoprecipitation drug loading and release studies of water sol. Drug J Contr Release.1999;57:171-85.
14. Ritger, P. L., & Peppas, N. A. A simple equation for description of solute release. I. Fickian and non-Fickian release from nonswellable devices in the form of slabs, spheres, cylinders or discs. J Contr Release.2001;5:23-36.