D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: A management study

Blood

Volumn 124, Issue 2, 2014, Pages 196-203

  Palareti, Gualtiero ^a   Cosmi, Benilde ^a   Legnani, Cristina ^a   Antonucci, Emilia ^b   De Micheli, Valeria ^c   Ghirarduzzi, Angelo ^d   Poli, Daniela ^b   Testa, Sophie ^e   Tosetto, Alberto ^f   Pengo, Vittorio ^g   Prandoni, Paolo ^g  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b University Hospital   (Italy)

^c A MANZONI HOSPITAL   (Italy)

^d Unit of Reproductive Medicine and Surgery   (Italy)

^e CREMONA HOSPITAL   (Italy)

^f Hospital of Vicenza   (Italy)

^g UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

D DIMER;

ADULT; ANTICOAGULATION; ARTICLE; BLEEDING; CLINICAL ASSESSMENT; CLINICAL PRACTICE; COHORT ANALYSIS; DEEP VEIN THROMBOSIS; FEMALE; FOLLOW UP; HUMAN; LOW RISK PATIENT; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTPATIENT; PATIENT SAFETY; PERSONAL EXPERIENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECANALIZATION; RECURRENCE RISK; RECURRENT DISEASE; RISK FACTOR; THROMBOSIS;

AGED; ANTICOAGULANTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PREGNANCY; RECURRENCE; TIME FACTORS; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM; WITHHOLDING TREATMENT;

EID: 84904109893     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-01-548065     Document Type: Article

References (30)

1. Christiansen SC, Cannegieter SC, Koster T, Vandenbroucke JP, Rosendaal FR. Thrombophilia, clinical factors, and recurrent venous thrombotic events. JAMA. 2005;293(19):2352-2361. (Pubitemid 40676757)
2. Prandoni P, Noventa F, Ghirarduzzi A, et al. The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients. Haematologica. 2007;92(2):199-205.
3. Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e419S-e494S.
4. Agnelli G, Prandoni P, Santamaria MG, et al; Warfarin Optimal Duration Italian Trial Investigators. Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. N Engl J Med. 2001;345(3):165-169. (Pubitemid 32662124)
5. Boutitie F, Pinede L, Schulman S, et al. Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants' data from seven trials. BMJ. 2011;342:d3036.
6. Palareti G, Cosmi B, Legnani C, et al; PROLONG Investigators. D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med. 2006;355(17):1780-1789. (Pubitemid 44631361)
7. Prandoni P, Prins MH, Lensing AW, et al; AESOPUS Investigators. Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial. Ann Intern Med. 2009;150(9):577-585.
8. Prandoni P, Cogo A, Bernardi E, et al. A simple ultrasound approach for detection of recurrent proximal-vein thrombosis. Circulation. 1993;88(4 Pt 1):1730-1735. (Pubitemid 23296919)
9. Legnani C, Cini M, Cosmi B, et al. Age and gender specific cut-off values to improve the performance of D-dimer assays to predict the risk of venous thromboembolism recurrence. Intern Emerg Med. 2013;8(3):229-236.
10. Cosmi B, Legnani C, Tosetto A, et al; PROLONG Investigators (on behalf of Italian Federation of Anticoagulation Clinics). Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study. Blood. 2010;115(3):481-488.
11. Fedullo PF, Tapson VF. Clinical practice. The evaluation of suspected pulmonary embolism. N Engl J Med. 2003;349(13):1247-1256. (Pubitemid 37152035)
12. Kearon C. Diagnosis of pulmonary embolism. CMAJ. 2003;168(2):183-194. (Pubitemid 36126783)
13. Schulman S, Kearon C; Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005;3(4):692-694. (Pubitemid 41647882)
14. Iorio A, Kearon C, Filippucci E, et al. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med. 2010;170(19):1710-1716.
15. Shen LZ. Sample size determination for controlling the upper confidence limit of incidence rate of a binomial endpoint. J Biopharm Stat. 1998;8(3):489-496. (Pubitemid 28417251)
16. Kearon C, Iorio A, Palareti G; Subcommittee on Control of Anticoagulation of the SSC of the ISTH. Risk of recurrent venous thromboembolism after stopping treatment in cohort studies: recommendation for acceptable rates and standardized reporting. J Thromb Haemost. 2010;8(10):2313-2315.
17. Prandoni P, Lensing AWA, Prins MH, et al. Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med. 2002;137(12):955-960. (Pubitemid 35440241)
18. Piovella F, Crippa L, Barone M, et al. Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with recurrence and new thrombosis. Haematologica. 2002;87(5):515-522. (Pubitemid 34533278)
19. Young L, Ockelford P, Milne D, Rolfe-Vyson V, Mckelvie S, Harper P. Post-treatment residual thrombus increases the risk of recurrent deep vein thrombosis and mortality. J Thromb Haemost. 2006;4(9):1919-1924. (Pubitemid 44226769)
20. Siragusa S, Malato A, Saccullo G, et al. Residual vein thrombosis for assessing duration of anticoagulation after unprovoked deep vein thrombosis of the lower limbs: the extended DACUS study. Am J Hematol. 2011;86(11):914-917.
21. Carrier M, Rodger MA, Wells PS, Righini M, LE Gal G. Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep vein thrombosis: a systematic review and meta-analysis. J Thromb Haemost. 2011;9(6):1119-1125.
22. Hager K, Platt D. Fibrin degeneration product concentrations (D-dimers) in the course of ageing. Gerontology. 1995;41(3):159-165.
23. Pieper CF, Rao KMK, Currie MS, Harris TB, Cohen HJ. Age, functional status, and racial differences in plasma D-dimer levels in community-dwelling elderly persons. J Gerontol A Biol Sci Med Sci. 2000;55(11):M649-M657. (Pubitemid 32010310)
24. Harper PL, Theakston E, Ahmed J, Ockelford P. D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly. Intern Med J. 2007;37(9):607-613. (Pubitemid 47262895)
25. Rudnicka AR, Rumley A, Lowe GDO, Strachan DP. Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-year-old population. Circulation. 2007;115(8):996-1003. (Pubitemid 46328293)
26. Kyrle PA, Minar E, Bialonczyk C, Hirschl M, Weltermann A, Eichinger S. The risk of recurrent venous thromboembolism in men and women. N Engl J Med. 2004;350(25):2558-2563.
27. Baglin T, Luddington R, Brown K, Baglin C. High risk of recurrent venous thromboembolism in men. J Thromb Haemost. 2004;2(12):2152-2155. (Pubitemid 40185775)
28. McRae S, Tran H, Schulman S, Ginsberg J, Kearon C. Effect of patient's sex on risk of recurrent venous thromboembolism: a metaanalysis. Lancet. 2006;368(9533):371-378. (Pubitemid 44108120)
29. Rodger MA, Kahn SR, Wells PS, et al. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ. 2008;179(5):417-426.
30. Eichinger S, Heinze G, Jandeck LM, Kyrle PA. Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model. Circulation. 2010;121(14):1630-1636.