메뉴 건너뛰기




Volumn 34, Issue 7, 2014, Pages 513-519

Observational study on dipeptidyl peptidase-4 inhibitors: A real-life analysis on 360 patients from the ASL VCO territory in Italy

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIPEPTIDYL PEPTIDASE IV INHIBITOR; HEMOGLOBIN A1C; LIPID; METFORMIN; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

EID: 84904066782     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.1007/s40261-014-0196-z     Document Type: Article
Times cited : (7)

References (33)
  • 1
    • 84881044531 scopus 로고    scopus 로고
    • Diabetes Atlas Accessed 14 Mar 2014
    • International Diabetes Federation. Diabetes Atlas. 2013. http://www.idf.org/diabetesatlas/. Accessed 14 Mar 2014.
    • (2013) International Diabetes Federation
  • 2
    • 84856477196 scopus 로고    scopus 로고
    • National diabetes fact sheet Accessed 14 Mar 2014
    • Centers for Disease Control and Prevention. National diabetes fact sheet, 2011. http://www.cdc.gov/diabetes/pubs/pdf/ndfs-2011.pdf. Accessed 14 Mar 2014.
    • (2011) Centers for Disease Control and Prevention
  • 3
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group 10.1016/S0140-6736(98)07019-6
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 4
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • 1:CAS:528:DC%2BC38Xps1Kitb4%3D 3357214 22517736 10.2337/dc12-0413
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35:1364-79.
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 5
    • 84859404670 scopus 로고    scopus 로고
    • European Diabetes Working Party for Older People 2011 clinical guidelines for type 2 diabetes mellitus. Executive summary
    • 22183418 10.1016/S1262-3636(11)70962-4
    • Sinclair AJ, Paolisso G, Castro M, et al. European Diabetes Working Party for Older People 2011 clinical guidelines for type 2 diabetes mellitus. Executive summary. Diabetes Metab. 2011;37(Suppl 3):S27-38.
    • (2011) Diabetes Metab , vol.37 , Issue.SUPPL. 3
    • Sinclair, A.J.1    Paolisso, G.2    Castro, M.3
  • 7
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • 1:STN:280:DyaL287msFCmuw%3D%3D 3514343 10.1007/BF02427280
    • Nauck M, Stockmann F, Ebert R, et al. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1986;29:46-52.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3
  • 8
    • 0035405821 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
    • 1:CAS:528:DC%2BD3MXltVWiuro%3D 11423477 10.2337/diabetes.50.7.1562
    • Tourrel C, Bailbe D, Meile MJ, et al. Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes. 2001;50:1562-70.
    • (2001) Diabetes , vol.50 , pp. 1562-1570
    • Tourrel, C.1    Bailbe, D.2    Meile, M.J.3
  • 9
    • 53549085157 scopus 로고    scopus 로고
    • New drugs for type 2 diabetes mellitus: What is their place in therapy?
    • 1:CAS:528:DC%2BD1cXhsFCrsrvF 18840004 10.2165/00003495-200868150-00005
    • Krentz AJ, Patel MB, Bailey CJ. New drugs for type 2 diabetes mellitus: what is their place in therapy? Drugs. 2008;68:2131-62.
    • (2008) Drugs , vol.68 , pp. 2131-2162
    • Krentz, A.J.1    Patel, M.B.2    Bailey, C.J.3
  • 10
    • 77950891085 scopus 로고    scopus 로고
    • Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    • 1:CAS:528:DC%2BC3cXksl2hsLk%3D 20388897 10.1001/jama.2010.405
    • Phung OJ, Scholle JM, Talwar M, et al. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA. 2010;303:1410-8.
    • (2010) JAMA , vol.303 , pp. 1410-1418
    • Phung, O.J.1    Scholle, J.M.2    Talwar, M.3
  • 11
    • 84859721063 scopus 로고    scopus 로고
    • DPP-4 inhibitors in the management of type 2 diabetes: A critical review of head-to-head trials
    • 1:CAS:528:DC%2BC38XlvVSnuro%3D 22197148 10.1016/j.diabet.2011.11.001
    • Scheen AJ. DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials. Diabetes Metab. 2012;38:89-101.
    • (2012) Diabetes Metab , vol.38 , pp. 89-101
    • Scheen, A.J.1
  • 12
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • 1:CAS:528:DC%2BD2sXkvVOgu78%3D 17277036 10.2337/dc06-1732
    • Bosi E, Camisasca RP, Collober C, et al. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care. 2007;30:890-5.
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3
  • 13
    • 34547660561 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    • 1:CAS:528:DC%2BD2sXpsleksr8%3D 17485570 10.2337/dc07-0627
    • Goldstein BJ, Feinglos MN, Lunceford JK, et al. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30:1979-87.
    • (2007) Diabetes Care , vol.30 , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3
  • 14
    • 79955015666 scopus 로고    scopus 로고
    • Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks
    • 1:STN:280:DC%2BC3Mrot1SqsA%3D%3D 21342412 10.1111/j.1463-1326.2011.01385. x
    • Pfutzner A, Paz-Pacheco E, Allen E, et al. Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks. Diabetes Obes Metab. 2011;13:567-76.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 567-576
    • Pfutzner, A.1    Paz-Pacheco, E.2    Allen, E.3
  • 15
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • 1:CAS:528:DC%2BD2sXjs1SrtL4%3D 17300593 10.1111/j.1463-1326.2006.00698.x
    • Rosenstock J, Kim SW, Baron MA, et al. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab. 2007;9:175-85.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 175-185
    • Rosenstock, J.1    Kim, S.W.2    Baron, M.A.3
  • 16
    • 69949102359 scopus 로고    scopus 로고
    • Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin - Diabetes control and potential adverse events
    • 1:CAS:528:DC%2BD1MXhtFajt77K 19748066 10.1016/j.beem.2009.03.003
    • Ahren B. Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin - diabetes control and potential adverse events. Best Pract Res Clin Endocrinol Metab. 2009;23:487-98.
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , pp. 487-498
    • Ahren, B.1
  • 17
    • 77952315531 scopus 로고    scopus 로고
    • Addition of incretin therapy to metformin in type 2 diabetes
    • 20417840 10.1016/S0140-6736(10)60399-6
    • Scheen AJ, Radermecker RP. Addition of incretin therapy to metformin in type 2 diabetes. Lancet. 2010;375:1410-2.
    • (2010) Lancet , vol.375 , pp. 1410-1412
    • Scheen, A.J.1    Radermecker, R.P.2
  • 18
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    • 1:CAS:528:DC%2BD2MXpsVars7Y%3D 16043735 10.2337/diacare.28.8.1936
    • Ahren B, Pacini G, Foley JE, et al. Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care. 2005;28:1936-40.
    • (2005) Diabetes Care , vol.28 , pp. 1936-1940
    • Ahren, B.1    Pacini, G.2    Foley, J.E.3
  • 19
    • 34147189738 scopus 로고    scopus 로고
    • The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    • 1:CAS:528:DC%2BD2sXksVSrsbw%3D 17244786 10.1210/jc.2006-1882
    • Balas B, Baig MR, Watson C, et al. The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients. J Clin Endocrinol Metab. 2007;92:1249-55.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1249-1255
    • Balas, B.1    Baig, M.R.2    Watson, C.3
  • 20
    • 38149137991 scopus 로고    scopus 로고
    • Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia
    • 1:CAS:528:DC%2BD1cXnsVyjsQ%3D%3D 17925336 10.1210/jc.2007-1639
    • Mari A, Scherbaum WA, Nilsson PM, et al. Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia. J Clin Endocrinol Metab. 2008;93:103-9.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 103-109
    • Mari, A.1    Scherbaum, W.A.2    Nilsson, P.M.3
  • 21
    • 80052551137 scopus 로고    scopus 로고
    • Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: A prospective 24-week randomized placebo-controlled trial
    • 1:CAS:528:DC%2BC3MXhtlCnsb3F 21733061 10.1111/j.1463-1326.2011.01467.x
    • Lukashevich V, Schweizer A, Shao Q, et al. Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial. Diabetes Obes Metab. 2011;13:947-54.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 947-954
    • Lukashevich, V.1    Schweizer, A.2    Shao, Q.3
  • 22
    • 84867142621 scopus 로고    scopus 로고
    • One-year safety, tolerability and efficacy of vildagliptin in patients with type 2 diabetes and moderate or severe renal impairment
    • 1:CAS:528:DC%2BC38XhsVCgur7I 22690943 10.1111/j.1463-1326.2012.01634.x
    • Kothny W, Shao Q, Groop PH, et al. One-year safety, tolerability and efficacy of vildagliptin in patients with type 2 diabetes and moderate or severe renal impairment. Diabetes Obes Metab. 2012;14:1032-9.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 1032-1039
    • Kothny, W.1    Shao, Q.2    Groop, P.H.3
  • 23
    • 84899057835 scopus 로고    scopus 로고
    • Experience with vildagliptin in patients <75 years with type 2 diabetes and moderate or severe renal impairment
    • 1:CAS:528:DC%2BC2cXmvFGmtbc%3D 3889331 23821355 10.1007/s13300-013-0027-x
    • Schweizer A, Dejager S. Experience with vildagliptin in patients <75 years with type 2 diabetes and moderate or severe renal impairment. Diabetes Ther. 2013;4:257-67.
    • (2013) Diabetes Ther , vol.4 , pp. 257-267
    • Schweizer, A.1    Dejager, S.2
  • 24
    • 84861128556 scopus 로고    scopus 로고
    • An update in incretin-based therapy: A focus on dipeptidyl peptidase-4 inhibitors
    • 1:CAS:528:DC%2BC38XovVyqsr0%3D 22429011 10.2174/157339912800564007
    • Irons BK, Weis JM, Stapleton MR, et al. An update in incretin-based therapy: a focus on dipeptidyl peptidase-4 inhibitors. Curr Diabetes Rev. 2012;8:169-82.
    • (2012) Curr Diabetes Rev , vol.8 , pp. 169-182
    • Irons, B.K.1    Weis, J.M.2    Stapleton, M.R.3
  • 25
    • 79960831855 scopus 로고    scopus 로고
    • Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans
    • 1:CAS:528:DC%2BC3MXhtFKjtLbK 21507182 10.1111/j.1463-1326.2011.01414.x
    • Ahren B, Schweizer A, Dejager S, et al. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab. 2011;13:775-83.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 775-783
    • Ahren, B.1    Schweizer, A.2    Dejager, S.3
  • 26
    • 79954508355 scopus 로고    scopus 로고
    • Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial
    • 1:CAS:528:DC%2BC3MXksleqs7g%3D 21428727 10.1185/03007995.2011.568059
    • Barzilai N, Guo H, Mahoney EM, et al. Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Curr Med Res Opin. 2011;27:1049-58.
    • (2011) Curr Med Res Opin , vol.27 , pp. 1049-1058
    • Barzilai, N.1    Guo, H.2    Mahoney, E.M.3
  • 27
    • 79952651976 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in older patients with type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC3MXjt1Whs78%3D 21323504 10.1185/03007995.2011.554532
    • Doucet J, Chacra A, Maheux P, et al. Efficacy and safety of saxagliptin in older patients with type 2 diabetes mellitus. Curr Med Res Opin. 2011;27:863-9.
    • (2011) Curr Med Res Opin , vol.27 , pp. 863-869
    • Doucet, J.1    Chacra, A.2    Maheux, P.3
  • 28
    • 78649711971 scopus 로고    scopus 로고
    • Clinical experience with vildagliptin in the management of type 2 diabetes in a patient population <75 years: A pooled analysis from a database of clinical trials
    • 1:CAS:528:DC%2BC3MXlslamtQ%3D%3D 21114604 10.1111/j.1463-1326.2010.01325. x
    • Schweizer A, Dejager S, Foley JE, et al. Clinical experience with vildagliptin in the management of type 2 diabetes in a patient population <75 years: a pooled analysis from a database of clinical trials. Diabetes Obes Metab. 2011;13:55-64.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 55-64
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3
  • 29
    • 84881189911 scopus 로고    scopus 로고
    • Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): A 24 week, randomised, double-blind, placebo-controlled study
    • 1:CAS:528:DC%2BC3sXosVGju70%3D 23706759 10.1016/S0140-6736(13)60995-2
    • Strain WD, Lukashevich V, Kothny W, et al. Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. Lancet. 2013;382:409-16.
    • (2013) Lancet , vol.382 , pp. 409-416
    • Strain, W.D.1    Lukashevich, V.2    Kothny, W.3
  • 30
    • 84857903646 scopus 로고    scopus 로고
    • DPP-4 inhibitors and lipids: Systematic review and meta-analysis
    • 1:CAS:528:DC%2BC38XhsV2qtLs%3D 22215383 10.1007/s12325-011-0088-z
    • Monami M, Lamanna C, Desideri CM, et al. DPP-4 inhibitors and lipids: systematic review and meta-analysis. Adv Ther. 2012;29:14-25.
    • (2012) Adv Ther , vol.29 , pp. 14-25
    • Monami, M.1    Lamanna, C.2    Desideri, C.M.3
  • 31
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • 1:CAS:528:DC%2BC3sXhsF2ksbzP 23992602 10.1056/NEJMoa1305889
    • White WB, Cannon CP, Heller SR, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013;369:1327-35.
    • (2013) N Engl J Med , vol.369 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 32
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC3sXhsF2ksbzN 23992601 10.1056/NEJMoa1307684
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013;369:1317-26.
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 33
    • 84855849888 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase 4 inhibitors for treatment of type 2 diabetes
    • 1:CAS:528:DC%2BC38XisFSrtLs%3D 22424537 10.2174/157488611798918700
    • Mikhail N. Safety of dipeptidyl peptidase 4 inhibitors for treatment of type 2 diabetes. Curr Drug Saf. 2011;6:304-9.
    • (2011) Curr Drug Saf , vol.6 , pp. 304-309
    • Mikhail, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.